Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 66 for “"extracellular matrix proteins"”.
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Fibronectin and Laminin, extracellular matrix proteins, have an origin in mesoderm tissue and promote anterior neural tube closure in zebrafish
… and zebrafish. In all vertebrates, there is an extracellular matrix between the mesoderm and the developing neural tube. I hypothesized Fibronectin (Fn) and Laminin (Lam), extracellular matrix proteins, have an origin in mesoderm tissue and promote anterior neural tube closure. Supporting my …
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Growth Factor and Extracellular Matrix Regulation of Heifer Mammary Development
… the role of locally derived growth factors and extracellular matrix proteins in regulating prepubertal heifer mammary development. In the first experiment, short-term treatment of heifers with GH or E increased proliferation of mammary epithelial cells. Coinciding with increased epithelial cell …
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Decellularized Normal and Cancer Susceptible Mice Colons to Study the Contribution of the Extracellular Matrix to Cell Behavior and Colon Cancer Progression
… cancer lack architectural support and signaling proteins provided by the tissue extracellular matrix (ECM) which may influence cell behavior and cancer progression. Therefore, the ability to study cancer cells in the context of a matrix that is physiologically more relevant and to understand how …
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Matrix-mediated regulation of type 1 collagen synthesis and degradation in cultured fibroblasts
Stromal cells and the extracellular matrix (ECM) components provide the microenvironment that is pivotal for cell growth, motility, attachment and differentiation. Fibroblasts are some of the cells responsible for the synthesis of most of the extracellular matrix proteins. Type I collagen is the …
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The structural and functional changes of blood vessels during aging
… a robust expression of endothelin system proteins in the adventitia. Additionally, extracellular matrix proteins collagen and fibronectin, and the proliferation marker Ki67 showed strong adventitial origin. The changes observed in the vascular adventitia with aging clearly demonstrate an …
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Aging Effects on Arterial Mechanics and Matrix Remodeling
… are a composite structure composed of cells and extracellular matrix proteins. Passive arterial mechanical behavior is determined by the composition of extracellular matrix proteins, in particular elastin and collagen. Elastin provides reversible elasticity to the large elastic arteries during …
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TIS21 inhibits cell migration by downregulating expression of matrix metalloproteinases
… role in cancer cell migration and invasion. The matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules, and to perform key functions in tumor progression, and …
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Clinical Applications of Stem Cells in Ocular Surface Reconstruction.
… also employed to determine the distribution of extracellular matrix proteins in processed amniotic membrane (AM) carriers. Various components of the culture system (including carrier, media and cell type) were evaluated in a number of separate studies. The results of this thesis show that …
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Fibronectin splice isoforms in wound healing and vascular development
Fibronectins are a large family of extracellular matrix proteins that regulate cell adhesion, migration, differentiation and survival. Different isoforms of fibronectin arise via alternative splicing of the transcript of a single gene. Although many of the general functions of fibronectins have …
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Coaxial Electrospinning of Synthetic/Natural Polymer Combinations for Controlled Release of Active Components in Biomedical Applications
… with a particular emphasis on incorporating extracellular matrix proteins and biologically active components. By systematically investigating process parameters, this study elucidates the structural and functional properties of coaxial fibres and their implications for biological response. …
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The Role of Ca²⁺/CaM-Stimulated Phosphodiesterase 1C in Vascular Smooth Muscle cells of the Synthetic/Activated Phenotype
… proliferation, and the ability of HASMCs to bind extracellular matrix proteins. These effects were mediated without any major changes in global cAMP levels. Furthermore, a novel interaction between PDE1C and the TRPC cation channel was identified that may establish a role for PDE1C in calcium-cAMP …
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Involvement of eicosanoid signalling in epithelial cell migration
… as the eicosanoids. Changes in the expression of extracellular matrix proteins and their related integrin receptors have also been shown to be important in the advancement IBD and CC. In light of this, we have investigated the role of eicosanoids in cell migration a key process in IBD and CC. This …
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Brain microvascular endothelial cell dysfunction in schizophrenia: a preliminary report
… (BMECs) have paracellular and transcellular proteins, transporters, as well as important extracellular matrix proteins, which collectively contribute to maintaining proper BBB function. While previous studies have provided some insights into the role of the BBB in SZ pathophysiology, there is …
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The streptococcal collagen-like protein-1 (Scl1) is a multifunctional adhesin in extracellular matrix interactions, biofilm formation, and host colonization by group A Streptococcus
… accessibility to exposed host cell surfaces and extracellular matrix components create a model milieu for successful host colonization and potential biofilm formation. The initiation of biofilm is often mediated by bacterial surface adhesins and has been shown to interfere with wound healing by …
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Dendritic Cell Migration and Traction Force Generation in Engineered Microenvironments
… DC random motility (chemokinesis) on extracellular matrix proteins in the presence of chemokines. Then, using a microfluidic device, we present both single and competing chemokine gradients to murine bone-marrow derived DCs in a controlled, time-invariant microenvironment. We show that …
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Detection and characterization of rat hepatic stellate cells in a 3-dimensional, perfused, liver bioreactor
… factors to heterotypic cell interactions, to extracellular matrix proteins. Therefore, a system that serves to promote the health of all liver cell types through a 3-dimensional, perfused scaffold, and allows for self-organization of the liver cells in response to the engineered environment, …
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Spatially controlled engineering of myocardial tissue
… to accurately control the displacement of proteins and cells in vitro to mimic their natural spatial organization. Thus, we have investigated how spatially controlled engineering of protein interfaces can be used to direct cellular response and the organized assembly of tissues. Adhesive …
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RDH10 is Necessary for Initial Vagal Neural Crest Cell Contribution to Embryonic Gastrointestinal Tract Development
… family members such as RET and GFRα1, as well as extracellular matrix proteins. Novel models of HSCR, such as Rdh10trex/trex will improve our understanding of RA contribution to intestinal development and may lead to innovative non-surgical treatment approaches to reduce the morbidity and …
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Peptide microarrays for the discovery of cell-ligand interactions that direct cell state
… a library of peptides that are derived from extracellular matrix proteins and serve as a highly scalable synthetic microenvironment. We demonstrate that by displaying combinations of peptides on the surface of self-assembled monolayers, we can affect stem and cancer stem cell fate. In chapter …
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Microenvironmental Modulation of Breast Cancer Stem Cells Through Biological Matrix
… of cancer, constantly by modulating cell-matrix interactions. Scientists have tried to characterize and identify the TIC population but the actual extracellular cues in deciphering the fate of TICs have not been explored. The basic unanswered question is the phenotypic stability of this …
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