Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1050 for “"extracellular matrix"”.
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Altering Inhibitory Extracellular Matrix Promotes Remyelination
… sulfate proteoglycans (CSPGs) are a family of extracellular matrix molecules that provide structural rigidity to tissues and act as signalling molecules to neurons and glia in the developing nervous system. After injury, CSPGs become highly upregulated by astrocytes as part of the glial scar …
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Nanomechanics of cartilage extracellular matrix macromolecules
In this thesis, the shear and self-adhesion nanomechanical properties between opposing cartilage aggrecan macromolecules were probed. In addition, nanoscale dynamic oscillatory mechanical properties of cartilage and its type II collagen network was measured. Aggrecan shear nanomechanics was …
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Extracellular matrix protein receptors in Drosophila melanogaster
The extracellular matrix (ECM) is defined as the many different proteins and secreted substances between cells. The ECM plays a major role in the signaling pathways that stimulate cells to perform many varied functions, ranging from control of gene expression at the cellular level to …
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Hierarchical cell fluid extracellular matrix interaction in cell microenvironment
… between components of cell microenvironment, the extracellular matrix (ECM), cytoplasm, nucleus and fluid, are important phenomena that decide cell level physiological process and tissue engineering applications. One of those tissue engineering modalities is freezing of biomaterials, important in …
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Immune Responses Aginst Aldehyde Modified Extracellular Matrix in Atherosclerosis
… in the release of MDA that modified surrounding extracellular matrix (ECM) proteins. These modifications may subsequently target immune responses against the plaque ECM and influence the atherosclerotic process. Our studies provide evidence for the presence of MDA-modifications on ECM proteins …
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Glycation of Extracellular Matrix: A Solid-State NMR Study
… in the glycation reaction model in vitro extracellular matrix (ECM) and ribose-5-phosphate using solid-state nuclear magnetic resonance (SSNMR) spectroscopy. The background and motivations of this project are outlined in chapter 1. Chapter 2 reviews the current understanding of the …
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Extracellular matrix gene sequence variant analyses and Achilles tendinopathy
… function of their encoded proteins within the extracellular matrix (ECM) of the tendon.
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Extracellular Matrix-Derived Microcarriers as 3-D Cell Culture Platforms
… the cell-instructive capacity of tissue-specific extracellular matrix (ECM) to direct cell attachment, proliferation and differentiation, there is a need for the development of in vitro cell culture models that reflect the complexity of the ECM to improve stem/progenitor cell expansion and …
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Profiling muscle stem cell adhesion using extracellular matrix peptide arrays
… that aged SkM contains lower levels of certain extracellular matrix (ECM) components that are critical for proper adhesion of muscle stem cells (MuSCs), which are responsible for muscle regeneration. These observations support the notion that peptides derived from ECM proteins containing the …
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VE-cadherin mechanotransduction signaling and its regulation by extracellular matrix
… signaling pathways and the impact of the extracellular matrix environment on both barrier protective and barrier disruptive responses. Studies described in Chapter 2 indicate that VE-cadherin triggers a global signaling cascade that involves VEGFR2, PI3K, Integrins, FAK and RhoA GTPase. …
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Control of hepatocyte morphology and function by the extracellular matrix
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1992.
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Growth Factor and Extracellular Matrix Regulation of Heifer Mammary Development
… the role of locally derived growth factors and extracellular matrix proteins in regulating prepubertal heifer mammary development. In the first experiment, short-term treatment of heifers with GH or E increased proliferation of mammary epithelial cells. Coinciding with increased epithelial cell …
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Effects of Liver Extracellular Matrix Gel Stiffness on Primary Hepatocyte Function
The extracellular matrix is a complex environment of mechanical and chemical cues vital to individual cell growth, tissue formation, and ultimately complete organ function. The field of regenerative medicine aims to recreate the unique biological properties found in specific tissue types and to …
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Extracellular matrix based substrates for propagation of human pluripotent stem cells
… on the identification and characterization of extracellular matrix (ECM) substrates for hPSC propagation. ECM substrates derived from mouse and human fibroblasts were assessed for their ability to support self-renewal of hPSCs. Characterization of hPSCs on ECM-based substrates demonstrated …
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Mechanical Deformation of the Extracellular Matrix Mediates Cellular Activation and Mechanotransduction
… and stress) is constantly applied to the cardiac extracellular matrix (ECM) at the cellular level (i.e. myocyte contraction and/or fibroblast focal adhesions) or globally through hemodynamic pressures. While mechanical load can be an important factor in maintaining tissue homeostasis, little is …
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Analyzing Interactions Between Cells And Extracellular Matrix By Atomic Force Microscopy
Interactions of cells with the extracellular matrix (ECM) have important roles in various physiological and pathological processes, including tissue morphogenesis during embryonic development, wound healing and tumor invasion. Although most of the proteins involved in cell-ECM interactions have …
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MODELING OF THE CHEMOMECHANICAL INTERACTIONS BETWEEN CELLS AND THE EXTRACELLULAR MATRIX
… the complex interactions between cells and the extracellular matrix (ECM) is crucial. These interactions involve biochemical signals and mechanical forces that regulate vital cellular processes, including migration, differentiation, and proliferation. Disruptions in these interactions frequently …
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Cell shape & integrins : determinants of extracellular matrix regulation of growth & survival
Thesis (Ph. D.)--Massachusetts Institute of Technology, Whitaker College of Health Sciences and Technology, 1997.
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