Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"extracellular matrices"”.
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Design of Artificial Modular Extracellular Matrices
… are essentially controlled by the surrounding extracellular matrix (ECM). The mechanical, chemical and structural properties of the ECM are consequently crucial for the selection of cells at interfaces and the formation of tissues. The objective of this thesis was to develop an artificial ECM …
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Thiol-Norbornene Hydrogels With Tunable Mechanical Properties for Engineered Extracellular Matrices
The extracellular matrix (ECM) governs many cellular processes through biochemical and mechanical cues. Particularly, the effect ECM mechanical properties on cells fate has been well established over the years. Many hydrogel systems have been used to mimic the dynamic stiffening processes occurring …
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Biomimetic Extracellular Matrices for In Vitro Cancer Models and Tissue Engineering Platforms
This thesis describes approaches to resolve inadequacies with current hydrogels used for cancer models and tissue engineering platforms, namely, (i) overcoming light scattering in nanofibrillar hydrogels, (ii) independently controlling matrix stiffness from other matrix properties, and (iii) …
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Endothelial cell response to bioactive peptides and stiffened extracellular matrices: an investigation into atherogenic pathways
Endothelial dysfunction is the initiating step in atherosclerosis and leads to cardiovascular disease outcomes. This dysfunction can be mitigated by cardioprotective signaling molecules such as nitric oxide (NO) which can be upregulated in the presence of bioactive milk peptides. An investigation …
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Elucidating Cell Fate Regulation of the Bone Marrow Vascular Niche Through Development of Engineered Extracellular Matrices
… two-dimensional scaffold comprised of several extracellular matrix (ECM) components. HSPCs that were co-cultured on ECM-mimicking scaffolds maintained higher viability in culture for up to seven days in comparison to solo-culture counterparts, and functional tests revealed an improvement in …
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Mathematical modelling of growth factor induced cell migration in 3D engineered matrices
… in a collective in three-dimensional engineered extracellular matrices governed by the mechanical properties of the matrix and a growth factor gradient. In the developed model, each cell is assumed to transmit a traction force that locally deforms a planar elastic substrate, resulting in …
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Engineering polymer biomaterial interfaces for promoting cellular morphogenesis
… relying on poorly characterized natural extracellular matrices (ECMs) for growth and development. These models are notably limited by the lack of vasculature, a key functional component of most human tissues, enabling oxygen and nutrient exchange, as well as facilitating paracrine …
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Vascular endothelial cell-surface proteoglycans
… cells. Studies of the effects of various extracellular matrices on the proliferative behaviour of bovine aortic endothelial cells in culture revealed that extracellular matrix material from rat smooth muscle cells stimulated proliferation more than did other matrices. Bovine aortic …
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Engineering Collagen Nanostructure to Enable Stiff & Tough Cartilage Biomaterials
Collagen is the main component of extracellular matrices (ECM) throughout the body, and the main structural component of cartilage tissue. As such, collagen has been widely investigated as a biomaterial for tissue engineering. However, the process of extracting collagen and processing it to form …
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Einfluss von Haptoglobin auf Adhäsion/Invasion von CD11b-positiven Leukozyten an/in extrazelluläre Matrices
… is reducing the binding of leukocytes to extracellular matrices via CD11b receptor. In uterine secretion during secretion phase about 130 to 220 ng/µl haptoglobin are detectable. This amounts are highly effective to reduce leukocyte binding to ECMs.
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Quantifying effects of substrata chemomechanical properties on eukaryotic and prokaryotic cell adhesion and morphology
… both mechanical and chemical signals from the extracellular environment. Exactly how these two factors affect the cell biology in the context of physiological circumstances is an area of intense interest that has given rise to an entire field of study called cell mechanotransduction. The …
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Progression of chondrocyte signaling responses to mechanical stimulation in 3-D gel culture
… of 3-D chondrocyte cultures increases extracellular matrix (ECM) production and mechanical stiffness in regenerating cartilage. The goal of this study was to examine the progression of chondrocyte signaling responses to mechanical stimulation in 3-D culture during tissue regeneration. …
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Synthesis of Hyaluronan by Tumour Cells – Mechanism and Implications
… (HA) is a glycosaminoglycan found in the extracellular matrices of epithelial and connective tissues. It has both structural and signalling functions, triggering various cell signalling cascades, which result in adhesion, migration and invasion. It has been reported that Squamous Cell …
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Mechanisms of Type IV Collagen Targeting to Developing Basement Membranes
<p>Basement membranes (BMs) are cell-associated extracellular matrices that support tissue integrity, signaling, and barrier properties. Type IV collagen is critical for the mechanical and signaling functions of BM. However, due to the challenge of imaging of BMs in vivo, the lethal phenotypes of …
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Monitoring and regulating cyanobacterial metabolites (microcystins and geosmin) in aquatic systems.
… of microcystin-LR between the intra- and extracellular matrices. Furthermore the control of microcystins in potable water has been explored applying photocatalysis over titanium dioxide. A novel product called Photospheres(TM) was assessed in its photocatalytic efficiency in the …
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Production of temporary bone scaffold reinforced with OPEFB-CMC from oil palm empty fruit bunch
… to demonstrate preferential proliferation and extracellular matrices and generate mineralised bones. The investigation was extended to in-vitro test involving Simulated Body Fluid (SBF) solution to evaluate the biodegradation rate and vi the growing of apatite layer during immersion. The …
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Evaluation of Downy Mildew (Peronospora farinosa f.sp. chenopodii) Resistance among Quinoa Genotypes and Investigation of P. farinosa Growth using Scanning Electron Microscopy
… penetrated stomata via appressoria, secreted extracellular matrices during sporangia germination, grew intercellularly in leaf and petiole tissues, and exited leaf tissue through stomata. Future research requiring knowledge of resistant quinoa genotypes, P. farinosa growth and development, or …
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Engineering Matrix Properties for Stem Cell Culture and Gene Delivery
… chemical properties of hydrogel-based synthetic extracellular matrices (ECMs). First, a synthetic stem cell niche with controlled stiffness and density of cell adhesion peptides was developed for spermatogonial stem cell (SSC) culture (Chapter 2). The synthetic stem cell niche allowed for the …
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Investigating the Role of Phosphodiesterase 1C in Vascular Smooth Muscle Cell Migration and Invasion
… signalling also coordinates HASMC invasion of extracellular matrices, a critical first step in HASMC migration in vivo. Indeed, while several cAMP-elevating agents reduce intimal hyperplasia/hypertrophy in animal models, it is presently unclear whether these effects are due to reduced matrix …
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