Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"extracellular fluids"”.
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Theoretical and Experimental Atomic Force Microscopy Investigations of Staphylococcus aureus
… model to a four spring model to account for extracellular fluids by considering them as fluids undergoing squeeze flow. The four spring model was validated theoretically with a more complex, two-dimensional Newtonian and viscoelastic (Phan-Thien Tanner) finite element model. The models were …
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NMR Studies on Protein Dynamics and Its Relevance to Functional Kinetics.
… proteins' characteristics in various biological fluids. Using this method we determined oxidation speed of HMGB1 protein in human blood serum and saliva, as well as in extracellular fluids. Different effect of these fluids on HMGB1's oxidation clearly showed the importance of in situ experiments …
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Application of Advanced Bioanalytical Techniques to Studies of Oxaliplatin Chemotherapy
… between ergothioneine and oxaliplatin in extracellular fluids forming positively-charged Pt(diaminocyclohexane)-ergothioneine conjugates with reduced capacity for cellular uptake. In an analysis of a clinical pharmacokinetic dataset, linear equations were established for estimating …
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Nitrogen oxide delivery systems for biological media
… pM, similar to what is expected to be present in extracellular fluids in the presence of 1 [mu]M NO. This system appears to be the first reported with the capability for sustained, quantitative NO2 delivery to suspended cell cultures. Results from initial efforts to test a novel mixing model for …
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Modeling of carbonization and stalling during radiofrequency ablation and electrosurgery
… drive ionic oscillations in intracellular and extracellular fluids, producing localized resistive heating. Depending on the applied waveform, duty cycle, and exposure duration, this heating can vaporize, coagulate, or denature tissue, enabling dissection, vessel sealing, or tumor ablation with …
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Characterisation of the leukaemia-associated ETO homologues
Acute myeloid leukemia (AML) is commonly associated with balanced chromosomal translocations. Characteristically, these translocations lead to the fusion of two unrelated genes, resulting in the expression of an aberrant fusion protein. t(8;21) is one of the most common translocations found in …
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Mechanisms for Targeting of Proteins to Secretory Lysosomes of Haematopoietic Cells
The cells of the innate immune system are essential for the host's first line defence against infection. Among these cells the neutrophil granulocyte has a central role by the production of antibiotic proteins and peptides. These are targeted for storage in secretory lysosomes and other neutrophil …
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The role of the leukemia-associated ETO homologue repressors in hematopoiesis
The fusion protein AML1-ETO is observed in acute myeloid patients with the chromosomal translocation t(8;21). Cells with this chimeric protein have impaired granulocytic and erythroid differentiation with accumulation of myeloblasts. The transcriptional co-repressor ETO (Eight Twenty One) was …
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TRIM22/Staf50 - a novel target gene of the tumor suppressor p53
The tumor suppressor gene p53 is a transcription factor that mediates cell cycle arrest, apoptosis and differentiation. p53 mediated differentiation of leukemic cells depends on the transcriptional activity of p53 but so far no obvious differentiation inducing target gene has been identified. Using …
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Characterization of human myeloid progenitors and their differentiation
All hematopoietic cells are derived from the hematopoietic stem cells (HSCs) in a continuous and dynamic process, regulated by a network of transcription factors in different combinations and extrinsic signals from growth factors (GFs) and other factors in the microenvironment. In the initial …
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Cytokine Regulation of Hematopoietic Stem Cells and Lymphopoiesis
Large numbers of blood cells need to be continuously replaced in order to sustain the crucial functions of the immune system, oxygen transport and blood clotting. The large diversity of cell types required to maintain the integrity of the blood system are all produced from blood forming or …
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A novel principle for immunomodulator delivery with hematopoietic cells as vehicles Focus on soluble TNF-receptor gene expression, targeting to secretory lysosomes and regulated secretion
The goal of this research is to use hematopoietic cells as vehicles for targeting transgenic immunomodulators to the inflammatory sites. The work presented was focused on the anti-inflammatory soluble TNF receptor. A transmembrane soluble TNF receptor (sTNFR1) construct was expressed in …
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Identification of Unique Hematopoietic Stem Cell Properties
Hematopoietic stem cells (HSC) are sufficient and required for life long production of all blood cell lineages. Steady state HSCs are largely quiescent and we demonstrate that the kinetics of HSC cell cycling are slower compared to more committed progenitor cells also during expansion and …
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The Wilms' tumor gene 1 (WT1) and leukemia -new insights and further complexity
The Wilms tumor gene 1 (WT1) encodes a zinc-finger containing transcription factor which is highly expressed in immature hematopoietic progenitor cells. A high expression of WT1 and the presence of somatic mutations in acute leukemia indicate a role for WT1 in the pathogenesis of leukemia. The …