Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"extra-cellular matrix"”.
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Design and Sythesis of Conjugages of Amphiphilic Cell-Penetrating Peptides Containing Anticancer Drug and Ligand for Extra Cellular Matrix Biomarker to Provide Efficient Tumor-Targeting
… of cancer such as the integrin receptor and extra-domain of fibronectin (EDB-FN) at the extracellular matrix. In the first studies, a series of targeting peptides targeting EDB-FN were synthesized and conjugated to different anticancer drugs. The synthesis, characterization, stability, and …
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Effects of Leptin on the Rat Cervix
… dry weight. Leptin also is capable of increasing cellular proliferation and collagen accumulation in the cervix. However, the studies conducted indicate that leptin may not modulate the extra-cellular matrix through matrix metalloproteinases, but leptin appears to play a role in the …
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MATRIX METALLOPROTEINASES AND LEFT VENTRICLE MASS AND FUNCTION
… studies have suggested the pivotal role of matrix metalloproteinases and NT- pro BNP in the pathogenesis of LV remodelling. Our objective was to establish a biomarker of cardiac extra cellular matrix (ECM) degradation that can be used to better identify asymptomatic individuals with …
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Biological tissue mechanics with fibres modelled as one dimensional Cosserat continua: applications to cardiac tissue in healthy and diseased states
… constituents, e.g. with regards to the extra cellular matrix, and their implications on the macroscopically observable material behaviour cannot be directly investigated. In this research the fibrous characteristics of the myocardium are modelled by one dimensional Cosserat continua. …
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Development, characterization and applications of a direct, general method to photochemically generate patterns and gradients on planar glass substrates, corrugated substrates and in highly porous collagen-GAG scaffolds
… chemical approaches to physically modeling the extra-cellular matrix (ECM) have provided invaluable insight into the molecular nature of cell adhesion and have clearly established the contributions of altered cell adhesion to disease onset and progression. In order to better understand the …
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Untersuchungen zur extrazellulären Matrix unter Implantation differenter Netzmaterialien zum Bauchwandersatz
… used. Because it is known that changes of the extra cellular matrix appear in hernia patients (alterations of collagen type -I/-III ratio, expression of MMP’s), it was the frame of this study to examine, which changes could be observed during mesh implantation in the extra cellular matrix …
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Modification of the Glycemic Status on Aortic Distensibility by Age in the Multi-Ethnic Study of Atherosclerosis
… distensibility (AD), such as glycation of the extra-cellular matrix. However, little data compares the simultaneous effects of elevated serum glucose and aging on AD. To study this, we examined the relationship between fasting glucose status, age, and AD in the Multi-Ethnic Study of …
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Engineering cellular microenvironments for directed cell growth and migration
… enabled these systems to precisely control the cellular microenvironments and investigate cell behavior in vitro. This work aims at integration of advances in life sciences and microfabrication techniques to address fundamental biological questions underlying cellular behavior. We specifically …
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Pharmacological investigations into matrix metalloproteinase-activated anti-tumour prodrugs. In vitro metabolic and pharmacological investigations into a series of colchicine-based peptide prodrugs activated by tumour-expressed matrix metalloproteinases
Matrix metalloproteinases (MMPs) play a significant role in degrading the extra- cellular matrix in cancer development and metastasis. Overexpression of matrix metalloproteinases in tumour tissues relative to normal tissues has been exploited as a target for peptide-based therapeutics, to improve …
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ALLOGRAFT DERIVED BIOSCAFFOLDS FOR TISSUE ENGINEERING OF THE MENISCUS: AN IN VIVO OVINE STUDY AND THE EFFECT OF HYPOXIC CULTURE ON SEEDED MENISCUS CONSTRUCTS
… limitations that have been linked to incomplete cellular incorporation, microscopic immune response, and limited long-term durability of these constructs. To overcome these limitations, this work investigated the use of a natural bioscaffold to mimic natural tissue architecture and biomechanical …
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The extraction of type 1 collagen and the fabrication of multi-filament embedded hydrogels for guided nerve regeneration
… which is the largest constituent of the extra- cellular matrix of living tissue. In this project, fabrication of novel constructs for nerve tissue guidance was carried out using homogenous hydrogels and multi-filament arrays of wet-spun fibers/hydrogel composites derived from extracted …
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Optimization of fluorescence lifetime imaging microscopy (FLIM) for studying the activity of enzymes in live cancer cells
… throughout this research is Membrane Type 1 Matrix Metalloproteinase (MT1-MMP) which is a membrane-bound protein principally responsible for degrading extra-cellular matrix (ECM) proteins in the local environment of a migrating cell. However, MT1-MMP has an intricate role in the regulation of …
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Mechanical stiffness-defined matrices for stem cell research and drug screening
… along neuronal, muscle, or bone lineages. Matrix elastic modulus can also control anchorage dependent cell's motility, localization, tissue formation and organization. Besides that, synthetic materials such as biodegradable polymers offer a versatile alternative to naturally derived …
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Alternative strategies to incorporate biomolecules within electrospun meshes for tissue enginering
… fibers-based electrospun meshes which mimics the extra-cellular matrix microarchitecture of ligament. However, challenges exist with incorporation of biomolecules. Therefore, the goal of this research project was to develop two techniques to incorporate biomolecules within electrospun meshes: (1) …
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Cell cycle regulatory proteins and miRNAs in premalignant lesions and breast cancer
… to alteration of genes associated with extra cellular matrix and actin-motility pathways in fibroblasts, and metabolic genes and pathways in co-cultured CCH epithelial cells. Finally, cyclin Dl associated miR-483-5p affected cell migration in opposite directions depending on estrogen …
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Regulation of Endothelial Nitric Oxide Synthase in Pulmonary Myofibroblasts
… also implicated in the fibroproliferation and extra cellular matrix deposition commonly seen in IPF. The nitric oxide (NO) signaling pathway is implicated in protomyofibroblast to myofibroblast transition and regulation. Previous work has shown that in pulmonary myofibroblasts, endothelial …
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A Bottom-Up Assembly Of Vascularized Bioartificial Constructs Using Ecm Based Microscale Modules
… that can promote cell-cell interaction, extra cellular matrix (ECM) deposition and tissue level organization. Accomplishing these prerequisites with the currently available conventional scaffolds and fabrication techniques still remains a challenge. To reproduce the full functionality …
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Zur Rolle von C5 und [alpha]5[beta]1-Integrin für die Entstehung von renaler Fibrose und mögliche therapeutische Konsequenzen
… transformation (E-cadherin, vimentin) and extra-cellular matrix proteins (collagen IV, fibronectin) were determined. As in C5-deficient mice as well as in animals treated with C5aR-anatgonist and/or integrin antagonist on day 5 a reduction of the markers for fibrosis could be recognized on …
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Role of Prostaglandin E2 In The Regulation of Pancreatic Stellate Cells Hyper Activity Associated With Pancreatic Cancer
… cells (PSC) are the predominant source of extracellular matrix production (ECM), thus being the key players in both diseases. Given this background, the primary objective is to delineate the role of PGE2 on human pancreatic stellate cells (PSC) hyper activation associated with pancreatic …
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Investigations into the digestive system proteases of Argiope aurantia (Araneae: Araneidae), hemolytic agents of spider venoms, and the role of both in necrotic arachnidism
… examined for its ability to cleave a variety of extra-cellular matrix proteins, including collagen, elastin, and fibronectin. Having confirmed that the fluid has collagenases, the digestive fluid was injected into the skin of rabbits to observe whether it would cause necrotic lesions. It did not. …
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