Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"extended survival"”.
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Single cell landscape of innate and adaptive immunity in metastatic melanoma treated with immunotherapy
… have revolutionized the care for cancer and extended survival for many patients. While ICIs have shown astonishing clinical benefits, less than 50% of patients experience a durable response. To find better biomarkers for ICI response and understand the diverse cellular players in the tumor, …
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The Heme-Regulated Inhibitor Pathway Modulates Susceptibility of Poor Prognosis B-Lineage Acute Leukemia to BH3-Mimetics
… bearing mice with both BTdCPU and a BH3-mimetic extended survival and repressed MCL-1 in vivo. These findings reveal that the HRI-dependent cellular heme-sensing pathway can modulate apoptosis in leukemic cells by repressing MCL-1 and increasing their responsiveness to BH3-mimetics. This …
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An Investigation into the Potential of Cell Therapies for Acute Myeloid Leukemia (AML) Treatment
… on AML cell lines and primary AML cells and extended survival in a Molm-13 GFP Luc xenograft model. Vγ9Vδ2 T cells also exerted an effective apoptotic effect in combination with venetoclax in the venetoclax resistant cell line, OCI-AML3, and improved survival in an OCI-AML3 GFP Luc xenograft …
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MicroRNAs in ALS: Defining Cell-Type Specific Expression, Developing Methods to Modulate MicroRNAs in vivo, and Identifying Novel Therapeutic Targets
… mice with anti-miR-155, we significantly extended survival by 10 days and disease duration by 15 days (38%) while a scrambled control anti-miR did not significantly improve survival or disease duration. Therefore, antisense oligonucleotides may be used to successfully inhibit miRNAs …
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The biology of ageing: pro- and anti-ageing signals from the reproductive system
… to a decrease in reproductive function and survival, which ends in death. The antagonistic pleiotropy theory for ageing suggests selection favours genes with positive effects on early life even if detrimental effects are observed in later life, indicating a trade-off between lifespan and …
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Regulatory mechanisms in transplantation tolerance: the induction of tolerance by adoptive transfer in MHC-inbred miniature swine
… organ failure. While one-year renal allograft survival has increased to over 90% in the past couple of decades with the use of new immunosuppressants, the long term survival of kidney allografts have remained the same due to unchanged rate of chronic rejection. Even with acceptance of renal …
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Investigating the potential of enhanced neuroprotection through unfolded protein response inhibition and autophagy induction in neurodegeneration
… in the hippocampus of both mouse models and extended survival of prion-diseased mice significantly. However, neither genetic nor pharmacological combination therapy showed additive benefit when given early in the disease. When starting genetic or pharmacological treatment in a later phase of …
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Characterizing ALCAM as an oncoprotein and immunotherapeutic target in neuroblastoma
… targeting the disialoganglioside GD2 have extended survival in neuroblastoma, relapse remains common. Thus, there remains a critical need for discovery of new immunotherapeutic targets. ALCAM is a cell-surface cell adhesion protein that is more highly expressed in neuroblastoma than a …
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Surviving a Terminal Diagnosis: the Ultimate Lifelong Learning Experience
… diagnosis or exceeded expected time limits for survival. Perhaps even more extraordinary, many of these consider it the "best thing" that ever happened to them. These are the modern eras' "mythical" heroes; they return bearing maps for our own eventual journeys. This study used a grounded theory …
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OPTIMIZATION OF AAV9 GENE THERAPY FOR SPINAL MUSCULAR ATROPHY WITH RESPIRATORY DISTRESS TYPE 1 USING IN VIVO DISEASE MODELS
… to the control. Treatments also resulted in an extended survival time, higher body weight, and improvement in motor behaviors. Histopathological analysis showed in muscles increased innervation of the neuromuscular junctions and enlargement of fibers diameter and, in spinal cords, increased …
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Characteristic analysis of mobility inducers for neural stem cells
… have in vivo therapeutic efficacy, we determined survival time of brain tumor animal model transplanted with NSC harboring suicidal gene and CM-1. The result of the in vivo experiment for CM-1 showed that human NSCs encoding cytosine deaminase (CD) migrated towards co-transplantation sites of …
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Nutritional Control of L1 Arrest and Recovery in Caenorhabditis elegans by Insulin-like Peptides and Signaling
… simultaneous disruption of ins-4 and daf-28 extended survival of L1 arrest without enhancing thermal tolerance, while overexpression of ins-4, ins-6 or daf-28 shortened L1 survival. Simultaneous disruption of several ILPs showed a temperature independent, transient dauer phenotype. These …
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Symptom Burden and Health-Related Quality of Life in Adults with Multiple Myeloma
… advances in the last 20 years have dramatically extended survival for many with MM. Overall median survival has increased from approximately two years in 2000 to more than five years in 2020. Though survival has improved, research suggests that those with MM experience high symptom burden and …