Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"expression variation"”.
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Two- and Three-dimensional Face Recognition under Expression Variation
In this thesis, the expression variation problem in two-dimensional (2D) and three-dimensional (3D) face recognition is tackled. While discriminant analysis (DA) methods are effective solutions for recognizing expression-variant 2D face images, they are not directly applicable when only a single …
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Computational methods for inferring regulatory mechanisms from sequence and expression variation
… the genetic variants contribute to phenotypic variation. With the vast majority of the genetic variants from Genome-wide Association Study (GWAS) located on the non-coding region of human genome, it is crucial to understand the gene regulatory mechanisms to be able to interpret the variants. …
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RNA-SEQ driven analysis of seasonal gene expression variation in miscanthus �� giganteus
… of M. × giganteus at the level of gene expression: a ten-tissue dataset suitable for examining genes with tissue-preferred expression, and a twenty-four sample dataset for examining the changes in gene expression that occur over the growing season. Aided by these datasets, aspects and …
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Associated behavioral, genetic, and gene expression variation with alternative life history tactics in salmonid fishes
… and often reflect underlying genetic variation. My research focuses on three objectives related to individual level variation: 1) evaluating the innate behavioral variation within and between individuals, families, and progeny of different life-history types across time; 2) testing for …
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Single-Cell Gene Expression Variation as A Cell-Type Specific Trait: A Study of Mammalian Gene Expression Using Single-Cell RNA Sequencing
… tissues to characterize patterns of gene expression across single cells, transcriptome-wide and in a cell-type-specific manner (Part 1). Additionally, we characterized single-cell RNA sequencing methods as a resource for experimental design and data analysis (Part 2). Part 1: …
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Chromatin Accessibility Beyond the Peaks
… help decode the regulatory logic governing gene expression. I present fiber-views, a software package for analysis of Fiber-seq data at aligned genomic positions. In the application of Fiber- seq to Zea mays I show Fiber-seq detects twice as many ACRs as ATAC-seq in paired samples. Fiber-seq is …
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Mapping PAMP Responses and Disease Resistance in Brassicas
… measuring early cell signalling responses, gene expression changes, cell wall reinforcement, metabolome changes and scoring PAMP-Induced resistance. Illumina-based RNA sequencing analysis produced a genome-wide survey of transcriptional changes upon PAMP treatment seen in both the A and C genomes …
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Statistical Methods for the Analysis of Contextual Gene Expression Data
… advances have enabled profiling gene expression variability, both at the RNA and the protein level, with ever increasing throughput. In addition, miniaturisation has enabled quantifying gene expression from small volumes of the input material and most recently at the level of single …
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Decoding divergence in marine protistan communities: from strain diversity to basin biogeography
… diversity translate to measurable phenotypic variation is needed to predict the impact of protists on marine biogeochemistry and protists’ environmental change sensitivity. I cultured twelve strains of the coccolithophore Gephyrocapsa huxleyi across temperatures, which revealed strain-specific …
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Decoding divergence in marine protistan communities: from strain diversity to basin biogeography
… diversity translate to measurable phenotypic variation is needed to predict the impact of protists on marine biogeochemistry and protists’ environmental change sensitivity. I cultured twelve strains of the coccolithophore Gephyrocapsa huxleyi across temperatures, which revealed strain-specific …
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Molecular Characterization of the Regulatory Subunits of Voltage -Dependent Calcium Channels From Rat Heart
… subunits systematically, I have identified expression of 4 beta, 3 alpha2delta and 3 gamma subunits from rat heart. Using phylogenetic analysis, I have studied the mammalian gamma subunit gene family and proposed the following relationship ((((gamma2, gamma 3), (gamma4, gamma8)), (gamma5, …
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Integrated Genomics Of Susceptiblity To Therapy-Related Leukemia
… strategies. In this thesis work, we identified expression networks that are associated with t-AML susceptibility in mice. These networks are robust in that they emerge from distinct methods of analysis and from different gene expression data sets of hematopoietic stem and progenitor lineages. …
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Characterization, annotation and expression patterns of bovine X-degenerate Y-chromosome genes UTY, ZFY, USP9Y, PRKY, RPS4Y, TBL1Y and their isoforms
… of these genes, identify their isoforms and expression patterns in male and female animals, through single molecule RNA sequencing and PCR amplification of gene sequences across 15 different tissues samples. Comparison to their human and mouse orthologues helped assess the structure and level …
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The Spatiotemporal Dynamics of Nutrient Exchange at the Arbuscule
… phosphate transport, revealed highly specific expression-timing and localisation, largely coinciding with arbuscule branching, which are essential for functional AM symbiosis. Surprisingly, OsAMT3;1, responsible for ammonium transport in the same direction, showed a longer window of expression …
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Discovery and characterization of genes controlling nitrogen utilization in maize
… component physiological traits, and gene expression variation were used as traits for quantitative trait loci (QTL) analysis. Subsequent fine mapping using dense SNPs generated with genotyping-by-sequencing (GBS) greatly narrowed down primary QTL intervals and resulted in a small number of …
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Regulation of floury2-mRFP expression in response to long term selection for grain protein concentration in maize
… is that the response depends on quantitative expression variation of a few major regulators. Analysis of crosses between IHP and Illinois Reverse High Protein (IRHP) provides evidence that the response to selection in IRHP is due to one or a few loci with main effects, which is associated with …
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The effect of non-coding variants on gene transcription in human blood cell types
… in the DNA sequence or by dysregulation of gene expression. To understand cell regulation, first connections have to be found between elements contributing to gene expression and its regulation. During my PhD I have studied the regulatory effects of human genetic variation. To do so I have …
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CRISPR activation screening at single-cell transcriptomic resolution: discovering new regulators of zygotic genome activation
… methods to identify latent sources of gene expression variation and differential gene expression analysis. Amongst the top hits, I identify the DNA binding protein Dppa2, the chromatin remodeller Smarca5 and the transcription factor Patz1. I subsequently validate these top hits using both …
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Dissecting Drivers of Basal Immunity and Acute Responses to Viral Infection
… environmental, and genetic factors in immune variation; however, they are often focused on a specific subset of the population (e.g. ancestral group, age range) which can exclude phenotypes unique to a diverse population and bias results. To address this gap, we have utilized samples from …
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Computational analysis and method development for high throughput transcriptomics and transcriptional regulatory inference in plants
… in different cell types as well as their expression analysis across various conditions. Due to its ability to provide in-depth insights into transcription and post-transcription mechanisms, RNA-seq has been extensively used in functional genetics and transcriptomics, system biology and …
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