Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 249 for “"expression profiling"”.
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Gene expression profiling of myostatin null mice
… mechanisms for each effect. We examined gene expression profiles of these mice to identify downstream targets of myostatin null- and clenbuterol-induced skeletal muscle hypertrophy. Microarray analysis was not successful at identifying gene expression differences between clenbuterol-treated …
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Gene expression profiling of polyamine-depleted Plasmodium falciparum
… falciparum by using differential transcriptome profiling. Suppression subtractive hybridisation generated transcripts which were potentially up-and down-regulated due to endogenous polyamine depletion within the human malaria parasite P. falciparum. The resulting transcripts were subjected to a …
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MicroRNA Expression Profiling of Multipotent Adult Germline Stem Cells
… Array zeigte trotz geringen Unterschieden in der Expression von einigen Oncomirs, dass undifferenzierte maGSCS und ESCs aus einem 129/Sv Hintergrund sich in ihrem microRNAome kaum unterscheiden. Im Gegensatz dazu unterscheiden sich undifferenzierte maGSCs aus der transgenen Stra8-EGFP-Rosa-Maus …
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Immunohistochemical Evaluation and Gene Expression Profiling of Senile Lentigo
… facial senile lentigines and their gene expression profiles were investigated. MATERIAL AND METHODS: For routine and immunohistochemical study, formalin-fixed and paraffin-embedded tissue blocks obtained from 20 Korean patients (1 man, 19 women) were used. Immunohistochemical staining of …
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Gene expression profiling approach towards enhancement of malaria vaccine development
… priority. This dissertation describes three gene expression profiling experiments using RNA sequencing technology (RNASeq) applied to samples collected during clinical trials performed at the CAUCASECO research center in Cali, Colombia. In each case, peripheral blood samples from volunteers and …
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Gene Expression Profiling of the nip Mutant in Medicago truncatula
… was assigned to transcripts with altered expression patterns in order to characterize the nip mutation phenotypically as inferred from the transcriptome. Functional analysis revealed a large number of chaperone proteins were highly expressed in the nip mutant, indicating high stress in the …
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Cellular Immune Response And Gene Expression Profiling In Crohn's Dise
… the cellular immune response and microarray gene expression profiling in peripheral blood and surgical tissue from cd, uc and healthy control subjects. Nested pcr detected map dna in tissue from 10/12(83%) cd patients compared to 1/6(17%) non-ibd subjects. Fluorescence in situ hybridization (fish) …
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Analysis of B lymphocyte activation and differentiation by expression profiling
… The main hypothesis of this study was that EGR1 expression is regulated through a SLP65-dependent signaling chain and therefore, EGR1 overexpression in SLP65-/- mice could restore or at least partially rescue developmental blocks caused by the absence of SLP65 in B cells. The results revealed …
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Identifying Diagnostic Biomarkers: Gene Expression Profiling Leptin in Dental Pulp Tissue
… study is to investigate differential leptin gene expression in hypoxic (inflammatory) conditions. DPSCs were isolated from healthy adult third molars, supplemented with 1% serum containing media or osteogenic media, and cultured in hypoxic (3%) or normoxic (21%) conditions for 21-days. Later, …
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In Vivo Gene Expression Profiling of the Plague Bacillus, Yersinia Pestis
… to the plague bacillus I evaluated the expression profiles of in vitro and in vivo models of Y. pestis. The change in temperature from ambient (e.g. aerosol or flea midgut) to the mammalian host has been used as a model to understand the effects of temperature as a signal for virulence …
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High-throughput microfluidic living cell arrays for spatiotemporal gene expression profiling
… factors, the principle regulators of gene expression. To date, experimental investigation of spatial and temporal transcription factor activation patterns has been limited by the use of destructive measurement techniques that require averaging responses over large cell populations. …
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Development and implementation of ontology-based systems for mammalian gene expression profiling
The use of ontologies in the mapping of gene expression events provides an effective and comparable method to determine the expression profile of an entire genome across a large collection of experiments derived from different expression sources. In this dissertation I describe the development of …
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Gene expression profiling in Saccharomyces cerevisiae grown at different specific gravity environments
The global gene expression profiles of industrial strains of Saccharomyces cerevisiae responding to nitrogen deficiency and very high sugar concentrations stresses were determined by oligonucleotide microarray analysis of ~ 6200 yeast open reading frames. Genomics analysis showed that 400 genes in …
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Gene expression profiling of patients with Polycythaemia Rubra Vera using cDNA microarrays
… not yield reproducible results. Nevertheless, expression of the mPRV-1 mRNA could be demonstrated from embryonic day 6.5 on by RT-PCR experiments. In order to obtain a model system for physiological analysis of the PRV-1 protein, transgenic mouse strains were generated which express the human …
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Molecular Classification of Basal Cell Carcinoma of Skin by Gene Expression Profiling
… Here, by performing comparative analysis of gene expression profiling of BCC, SCC, and normal skin tissues, we could classify the BCC into three subtypes of classical, SCC-like, and normal-like BCCs. Functional enrichment and pathway analyses revealed the molecular characteristics of each subtype. …
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Gene expression profiling reveals novel actions of glucocorticoids on immune cells during inflammation
… peritoneal macrophages by LPS, and those whose expression is further modulated upon administration of glucocorticoids (GC). In total, more than 350 genes/ESTs were identified as being induced or repressed by LPS, whereas 106 (30) of them responded to GC treatment. The molecular mechanisms of GC …
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Genome-wide census and expression profiling of chicken neuropeptide and prohormone convertase genes
… studies offered a comprehensive portrait of gene expression across multiple conditions. Five neuropeptide genes (apelin, cocaine- and amphetamine-regulated transcript protein, insulin-like 5, neuropeptide S, and neuropeptide B) previously unknown in chicken were identified and 62 genes were …
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A flow cytometry-based method for gene expression profiling of CNS cell types
In this thesis, I present a technique for profiling gene expression of specific cell types in the central nervous system (CNS), called fluorescence activated nuclei sorting (FANS). FANS utilizes flow cytometry to isolate cell nuclei from CNS subtypes and microarray analysis of nuclear mRNA. When …
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Osteocyte Activity and Skeletal Muscle Relative Gene Expression Profiling After Short-term Muscle Paralysis
… and determine if changes in gait, muscle gene expression, and markers of osteocyte activity could be detected as early as one week after Botox-induced muscle paralysis. In the present study, 20-week-old female rats were injected with botulinum toxin A (BTX, n=12) in the right hindlimb muscles, …
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