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Showing 1 to 20 of 328 for “"expression of genes"”.
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Organization and expression of genes encoding cytoskeletal proteins in Plasmodium falciparum
Contains fulltext : mmubn000001_083349839.pdf (Publisher’s version ) (Open Access)
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The impact of antipsychotic drugs on the expression of genes associated with obesity
… association studies have identified a number of genetic<br/>variants associated with obesity risk; however the effects of these risk variants on clozapineinduced weight gain have not been investigated. This doctoral thesis focused on the following research questions: (1) Does schizophrenia …
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Differential Expression of Genes During Diapause in the Flesh Fly, <em>Sarcophaga crassipalpis</em>.
<p>The objective of this study was to identify genes that are differentially regulated during diapause when compared with nondiapausing pupae in <em>Sarcophaga crassipalpis</em>. The results of a Suppression Subtractive Hybridization procedure was used to indentify genes that are differentially …
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Examination of the expression of genes and proteins controlling M. longissimus thoracis et lumborum growth in steers
The first study conducted investigated the effect of sire breed and genetic merit for growth potential of the transcriptional regulation of the somatotropic axis followed by a proteomic approach to assess differentially abundant proteins. Following this, a second study was set up to examine the …
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Effect of Low Dose Irradiation on Expression of Genes Involved in Ethylene Biosynthesis of 'Granny Smith' Apples
… browning that appears during or after storage of ‘Granny Smith’ apples. The mechanism for scald development is not fully understood, but it is hypothesized that scald formation is related to increased ethylene production. In apples, low dose irradiation induced ethylene reduction appears to be …
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Comparison of pregnancy rates, progesterone concentrations, and expression of genes associated with progesterone synthesis in heifers and mature cows
… declined, particularly in mature cows. Fertility of heifers that were bred for the first time has not been affected. One of the major reasons for such fertility decline in mature cows could be impaired progesterone production. Therefore relationships of parity with reproductive performance, its …
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Different Effect of 5-Fluorouracil on Expression of Genes Related to Aerobic Glycolysis According to Chemoresponsiveness in Gastric Cancer Cells
5-fluorouracil(5-FU) is one of the chemotherapeutic agents that has been used widely in gastric cancer. However, the responsiveness of 5-FU has been limited for several gastric cancer patients, and this limitation is believed to be caused by chemoresistance. To date, the mechanism of …
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Study of Mutations and Expression of Genes Correlated to the Appearance of Colorectal Cancer /// Проучване на мутации и експресия на гени, корелиращи с изявата на колоректален карцином
The aim of the current study was to analyse the mutational profile of RAS oncogene correlated to the expression levels of genes related to energy metabolism, hypoxia and genomic stability, as well as the expression levels of microRNAs and their role in regulating the previously mentioned signalling …
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Conformation and dynamics of the mammalian chromosome
The control of transcription represents a fundamental, initial mechanism by which the regulation of gene expression is implemented. However, while much research has been done on the biochemistry and cellular function of transcription, comparatively little is known on the dynamics of transcriptional …
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Comparison of the molecular phenotypes of pigs carrying different IGF2 alleles at four developmental time points
… fat deposition in pigs carrying a paternal copy of the A allele (Apat). While many studies have focused on the differences in between the gross phenotypes of these animals, relatively little has been done to understand how these animals differ at the molecular level. It was the objective of this …
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Regulation of cell-identity maintenance in C. elegans
Multicellular organisms are composed of a huge variety of different cell types, defined by their unique morphology, function, and gene expression. In animals, these characteristics are established during development, where internal and external cues guide the determination and differentiation of …
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Differences in Gene Expression Responses to Heat Shock Between Warm- and Cool-Adapted Isolates of Batrachochytrium dendrobatidis
Batrachochytrium dendrobatidis (Bd) is one of the most destructive emerging infectious diseases to impact wildlife populations in modern history. Bd displays drastically different patterns of infection, both between distinct amphibian species and between different climates; this has resulted in …
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Systemic Blockade of the Endocannabinoid System Alters Gene Expression and acquisition of a Hippocampus Dependent Learning Task
Thesis under the direction of Robert Hampson, Ph.D., Associate Professor of Physiology and Pharmacology It has been established that the administration of Δ9-THC and other cannabinoid agonists results in disruptions in learning and memory (Sullivan, 2000). The ability of rimonabant to reverse …
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Adaptation to environmental stress in the human placenta
… weight. To determine if differences in gene expression maybe contributing to physiological differences between individuals at high and low altitude, we tested for differences in gene expression and DNA methylation between Andean and European placental samples from La Paz (~4,000m) and Santa …
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Expression of single chain antibody-encoding genes in fission yeast and tobacco
The goal of this project was to explore the expression of genes encoding single chain antibodies (SCA) in eukaryotic cells. During the course of this research, a new PCR-based strategy was developed that significantly reduced the time required for SCA gene synthesis. Although initially developed …
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Gene and Protein Profiling of the Preeclamptic Placenta
Aims State-of-the-art methodology was used to screen and profile the placenta, gene and protein expression, for changes related to preeclampsia (PE) and cases with increased resistance in the uterine arteries. Women with increased resistance in the uterine arteries have increased risk of developing …
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Effects of Dietary Conjugated Linoleic Acid Supplementation on Bovine Oocyte Lipid Metabolism, Lipid Composition and Embryo Cryotolerance
… Reduced tolerance to chilling and cryotolerance of oocytes and embryos has been associated with greater cytoplasmic lipids (Kim et al., 2001; Seidel, 2006). Previous studies in the cow have demonstrated nutrition-induced modification of follicular components. Trans-10, cis-12 conjugated linoleic …
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Investigations into the effects of berry flavonoids on nutrient transport processes in Caco-2 enterocytes
Flavonoids are known to interact with a number of membrane transporters, influencing the rate of intestinal nutrient absorption. The transcriptional effects and consequences of such interactions remained to be fully elucidated. To address this we carried out gene expression microarray analysis on …
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Oxygen and Glucose Deprivation on Human Müller Cells (MIO-M1) and Human Organotypic Retinal Cultures (HORCs) in Relation to Glaucoma
Purpose: The purpose of this research was to investigate the effect of glaucoma-related insults, specifically oxygen and/or glucose deprivation (OGD) on the survival and genes expression of human Müller cells (MIO-M1), and retinal ganglion cells (RGCs) using the human organotypic retinal culture …
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Engineering a cyanobacteriochrome two-component system into a synthetic, light-controlled gene expression system for plants
Our inability to perturb the expression of genes at cellular resolution in planta has hampered our investigation of spatial and temporal dynamics. Ideally, we would like an orthogonal, genetically encoded system, that allows us to reversibly perturb the expression of genes of interest with maximal …
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