Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"experimental medicine"”.
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Advanced Magnetic Resonance Imaging of Osteoarthritis
… for rapid assessment of treatment efficacy in experimental medicine studies. The development of treatments able to modify disease in OA is hampered by an inability to evaluate treatment response over a timeframe relevant to clinical trials. There are particular challenges in the experimental …
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Addressing Legal Liability Issues in Cases of Harm due to Agricultural Genetically Modified Organisms (GMOs): Does current liability law find a suitable balance between the injuring and injured party?
… research, production of pharmaceutical drugs, experimental medicine and agriculture.
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Modulating The Unfolded Protein Response as a Therapeutic Target in Alzheimer’s Disease
… inform the design of the next steps of potential experimental medicine studies to explore the impact of drugs on cerebral protein synthesis in people with Alzheimer’s disease. One drug proposed to inhibit the unfolded protein response is the antidepressant trazodone. Trazodone is a drug already in …
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Investigation of novel therapeutic strategies in B cell and antibody mediated disease
… of belimumab, an anti-BLyS antibody, in an experimental medicine study in kidney transplant recipients. The rationale for this study was based on published studies showing that B cells activate alloreactive T cells and secrete human leukocyte antigen (HLA) and non-HLA antibodies that …
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Combinatorial lipid-like materials for intracellular delivery of small RNAs that activate innate antiviral immune responses and adjuvant vaccines
RNA-based therapy is an exciting new realm of experimental medicine due to the diverse roles of RNA in the human body. RNA function depends on sequence, structure, and cellular location. Whereas cytosolic short-interfering RNA (siRNA) can be used to turn off genes through RNA interference (RNAi), …
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Cardioprotective Effect of Lipid Emulsion on Acute Exogenous Drug Intoxications // Кардиопротективен ефект на липидна емулсия при остри екзогенни интоксикации с медикаменти
… and applied value for both clinical practice and experimental medicine. This knowledge will contribute to a better understanding of the mechanisms of action of LE, the risks, associated with its use, and also improve the quality and effectiveness of treatment in patients with acute intoxications …
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The effect of Alzheimer's disease on cortical microcircuits
… as a potential biomarker platform for experimental medicine studies of novel compounds. To this end, NTAD includes clinical, cognitive and neuroimaging measures from participants with mild cognitive impairment or early dementia from Alzheimer’s disease and neurologically-healthy control …
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Genotype and phenotype in mitochondrial disorders
Mitochondrial disorders are inherited metabolic conditions caused by pathogenic variants in genes affecting oxidative phosphorylation and ATP synthesis. They are a heterogeneous group of disorders with an incidence of 1 in 5000. They can affect a single organ or multiple systems, with age of onset …
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Low-dose IL-2 for T-regulatory cell expansion after alemtuzumab therapy in relapsing-remitting multiple sclerosis
T-regulatory cells (Tregs) are vital for the prevention of autoimmunity, and they require interleukin-2 to function optimally. Their expression of the high-affinity IL-2 receptor, containing the CD25 subunit, renders them 10-fold more sensitive to IL-2 than effector cells (Teffs). Low-dose IL-2 …