Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 28 for “"experimental evolution"”.
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Experimental evolution of Burkholderia cenocepacia biofilm populations
… infections. Here we describe the parallel evolution of cooperative communities derived from a clone of Burkholderia cenocepacia during approximately 1500 generations of biofilm selection. This long-term evolution was enabled by a new experimental method that selects for daily cycles of …
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Cooperation, conflict, and experimental evolution in social amoebae
… the importance of high relatedness in the evolution of cooperation and cheater resistance. In an experimental evolution study, we tested the hypothesis that de novo cheater mutants readily evolve under low relatedness conditions. We found that the majority of our lines evolved to cheat …
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Testing the Major Theories Concerning the Evolution of Sex using Experimental Evolution
The evolution of sexual reproduction has been dubbed "the queen of problems in evolutionary biology". While there is a large amount of theory about the evolution of sex, there is relatively little well controlled empirical data. This thesis is an attempt to use an experimental evolution based …
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Evolvability of a viral protease: experimental evolution of catalysis, robustness and specificity
… thesis is to investigate aspects of molecular evolution and enzyme engineering using the experimental evolution of Tobacco Etch Virus cysteine protease (TEV) as a model. I map key features of the local fitness landscape and characterise how they affect details of enzyme evolution. In order to …
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Experimental Evolution with Escherichia coli in Diverse Resource Environments: are 'Jacks of all Trades' truly 'Masters' of None?
… unavoidable, even if they fail to constrain the evolution of generalists for several thousand generations.
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Diet, adaptation and the evolution of assortative mating in Ceratitis capitata
… in a range of natural populations. However, experimental tests of the role of divergent natural selection in the establishment of reproductive isolation are still scant. To address this omission, the role of larval diet in imposing divergent selection and causing ecological adaptation and …
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Population genomics and domestication of the Black Soldier Fly (Hermetia illucens L.)
… agricultural activity. Improved knowledge of the evolutionary history, genetic diversity and potential for genetic improvement of this species will be fundamental to the success of this important industry. I investigate the role of domestication and its impact on the genome of *H. illucens*. I …
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The Distribution of Fitness Effects of Synonymous Mutations in a Gene under Selection
Models of adaptive evolution consider the path that a population takes to a fitness optimum through a series of beneficial single-nucleotide changes, although synonymous mutations, which do not alter the amino acid sequence, have been conventionally seen as ‘silent’ changes. However, recent studies …
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Hypermutation and adaptation of experimentally evolved marine Vibrio bacteria
… of bacteria for industrial applications. Experimental evolution is a powerful approach, with microbes especially, but it has mostly been applied to model organisms and metabolic functions. In the work here, we investigated the possibility, degree, and variability of adaptation of an …
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Preserving spore dormancy
… a potential germinant during sporulation. Experimental evolution showed that germinant sensing can adapt when clearance is disrupted. Suppressor populations restored stable, heat-resistant spore production despite alanine accumulation. Most adaptations tuned the germinant receptor rather …
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Evolution's footsteps : reconstructing in vitro and in vivo evolutionary trajectories via massively parallel sequencing and profiling
… is a fundamental question of biology. Microbial evolution studies provide the rare opportunity to experimentally elucidate the changes that allow an organism to adapt to novel conditions. In an in vitro experimental evolution system, cells evolve in response to a lab-controlled selective …
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Understanding microbial communities through horizontal gene transfer
… key ecosystem functions. Motivated by the experimental observation that communities from garden composts were capable of maintaining high diversity in single-carbon-source microcosms, I started by tracing the community assembly process under a serial transfer regime at a higher resolution …
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Identification of Receptor Transporting Proteins As Conserved Antiviral Effectors in Vertebrates
… each side attempts to gain the advantage over evolutionary time. Results of these conflicts are wide-ranging: viruses diversify, hosts establish species-specific barriers to some viruses while remaining susceptible to others, and the lines for future genetic conflicts are drawn. In mammals, …
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Functions of Dcp2 and Ski7 In Mrna Degradation
… growth defect of a <em>DCP2</em> null mutant via experimental evolution and genome sequencing. These suppressors act by at least three independent mechanisms. They do not rescue defects in mRNA decay. Instead, they appear to partially alleviate global disturbance of the transcriptome in the …
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Specificity in the ecology and evolution of plant defense against herbivores: Identity and history
… interact to influence traits in ecological and evolutionary time. Moreover, variation in biotic interactions among native and introduced plant ranges may account for the spectacular success of some invasive species. For example, in novel environments plants may experience ecological release from …
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Ecological and evolutionary aspects of interactions between microbes coinfecting plants
… two species of BYDV (PAV and PAS) on pathogen evolution using an experimental evolution approach. Viruses exhibited altered within-host concentrations and transmission after serial passage in coinfections, without altered disease severity. Chapter 3 examines interactions between Bean common …
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Mechanisms of Emerging RNA Virus Adaptation to Hosts
… used either selective sweep detection methods or experimental evolution to identify viral mutations with putative adaptive potential. A selective sweep region was identified in the Spike gene of human SARS-CoV-2 sequences. A residue at site 519 in this region of Spike was identified that differed …
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Microbial adaptation to dissolved organic matter in freshwater ecosystems
… of DOM and the carbon cycle. I summarize current experimental approaches for studying microbial adaptation in novel environments and outline the objectives of the thesis. Chapter 2 investigates short-term responses of a six-species bacterial community to seven DOM sources that span a gradient of …
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The role of parents in Evolution
… I investigated the role of parental care in evolution. Parents provide the environment in which offspring develop and therefore have a large influence on their offspring's phenotypes, and so are in prime position to influence evolutionary processes. I used an experimental approach, and …
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Social Evolution in Action: Causes and Consequences
… interactions within the family contribute to evolutionary change has received much attention from behavioural ecologists and evolutionary biologists alike, with the former largely focussing on how these interactions are adaptive, and how they impose selection on each member of the partnership, …
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