Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"experimental autoimmune encephalomyelitis (EAE)"”.
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Aspects of the Immunobiology of Myelin Oligodendrocyte Glycoprotein (MOG)-induced Experimental Autoimmune Encephalomyelitis (EAE)
… investigated the immunobiology of MOG-induced EAE in the DA rat, an animal model, which reproduces the immunopathology of the type II MS lesion (Lucchinetti et al., 2000). A newly established immunisation protocol results in a highly synchronised biphasic form of EAE, which mimics the disease …
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Vaccination with DNA encoding a myelin autoantigen exacerbates experimental autoimmune encephalitis
The ultimate goal in the treatment of autoimmune diseases is to reestablish tolerance to self antigens. One strategy to induce tolerance is to express the target autoantigen by DNA vaccination. In this work, the potential of vaccination with a DNA construct encoding the myelin oligodendrocyte …
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Humanized Chimeric Receptors in the Therapy of Multiple Sclerosis
… such cells and have been proven to suppress autoimmune encephalomyelitis, the murine model of multiple sclerosis. We here demonstrate the ability of humanized chimeric receptors to suppress experimental autoimmune encephalomyelitis (EAE) in a humanized mouse model by redirecting T lymphocytes …
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Therapeutic Modulation of Experimental Autoimmune Encephalomyelitis by Gamma Secretase Inhibition
… TH1 differentiation and reduce the severity of experimental autoimmune encephalomyelitis (EAE), presumably by affecting Notch signaling. To understand the mechanisms through which γSI alter autoimmune T cell responses, we utilized an adoptive transfer model of EAE. We found that γSI treatment in …
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Generation and analysis of transgenic mice expressing ovalbumin as a neo-self antigen under control of the myelin basic protein promoter
In this project two novel murine autoimmune models were to be established in an attempt to further investigate the nervous system disorders of Multiple Sclerosis and Guillain Barré Syndrome. Previous experimental autoimmune encephalomyelitis (EAE) and experimental autoimmune neuritis (EAN) models …
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THE INNATE CYTOKINE IL-18 INHIBITS CNS AUTOIMMUNITY THROUGH PREFERENTIAL ACTIVATION OF PROTECTIVE CD8 T-CELLS
… with certain autoinflammatory, but not autoimmune, diseases. We tested how excess IL-18 affected susceptibility to experimental autoimmune encephalomyelitis (EAE), a model of CNS autoimmunity driven by IL-18 responsive, myelin-autoreactive CD4T-cells (CD4Tauto). Prior data suggested that …
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IFN-γ Induced Nitric Oxide Leads to the Inhibition of TH17 Differentiation via iNOS
Multiple Sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS), driven by autoreactive T cells that mediate demyelination, axonal loss, and neuroinflammation. Among the pathogenic T helper subsets, Th17 cells are pivotal in MS progression, producing high levels of …
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Vitamin D Inhibits Expression of Protein Arginine Deiminase 2 and 4 in Experimental Autoimmune Encephalomoyelitis Model Of Multiple Sclerosis
… factor for developing the disorder. Using the experimental autoimmune encephalomyelitis (EAE) model of MS we demonstrate vitamin D treatment to attenuate over-expression of PAD 2 and 4 in the brain and spine during EAE. In addition, we identify two molecules produced by peripheral immune cells, …
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The Role of Therapy-Induced CD8+ T Cells in a Mouse Model of Multiple Sclerosis
Murine experimental autoimmune encephalomyelitis (EAE) is an induced, autoimmune, demyelinating disease model for human multiple sclerosis (MS). Glatiramer acetate (GA) is an approved immunomodulatory therapy for MS that was discovered through studies in EAE. It is thought that the main mode of …
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CNS-Specific, Autoreactive CD8+ T Cells Have a Regulatory Role in Autoimmune Demyelination
… of MS derives from work in its murine model, experimental autoimmune encephalomyelitis (EAE), which can be induced by inoculation with a specific neuroantigen or by adoptive transfer of CNS-specific activated T cells. The vast majority of studies in MS and EAE have focused on the role of CD4+ …
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Investigating the protective effects of farnesol formations against neuroinflammation
… FOL treatment would result in protection against experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis. We demonstrate that there is a correlation between reduced neuroinflammation and EAE severity observed in the context of FOL protection. We compared the …
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Antibodies to Heterogenous Nuclear Ribonucleoprotein A1 Penetrate Neurons Leading to Multiple Downstream Effects Resulting in Neurodegeneration
… the effect of anti-hnRNP A1 antibodies on experimental autoimmune encephalomyelitis (EAE), the murine model of MS. Specifically, we will present the effect of anti-hnRNP A1-M9 antibodies on clinical symptoms and neurodegeneration in EAE. Taken together, we present a series of experiments …
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CD1d restricted NKT cells in regulation of pathogenic autoimmunity
Human autoimmune diseases such as reumatoid arthritis (RA) and multiple sclerosis (MS) are believed to develop when self-tolerance mechanisms are failing, with a chronic destructive inflammation as result. To experimentally study autoimmunity, we have used murine models that mimic their human …
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Inflammatory astrocyte and T cell interactions are supported by hyaluronan in a murine model of Multiple Sclerosis
Multiple Sclerosis (MS) is an autoimmune disorder characterized by demyelination, neurodegeneration, and immune cell infiltration into the central nervous system (CNS). Inflammatory astrocytes, one of the first described subtypes of reactive astrocytes, are thought to play a role in the development …
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T Cell Intrinsic BCAP Links IL1R to the PI3K-mTOR Pathway and Regulates Pathogenic Th17 Differentiation
… development of pathogenic Th17 diseases, such as experimental autoimmune encephalomyelitis (EAE) and T cell transfer colitis. Further, the use of a potent inhibitor of mTOR, which is downstream of BCAP activation, mimics BCAP deficiency by preventing IL1b induced differentiation of pathogenic Th17 …
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Design of Antigen-Specific Immunotherapies Through Modulation of Peripheral Tolerance Pathways
Current therapies for autoimmune diseases lack specificity for the offending immune cell population resulting in a wide range of side effects and weakening of the immune system. This presents a clear need for antigen-specific immunotherapies (ASITs) capable of selectively modulating autoreactive …
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An investigation of the regulation of Sialoadhesin ligands on CD4+ T cells and its potential significance in Systemic Lupus Erythematosus
… regulatory T cells (Tregs) in a mouse model of experimental autoimmune Encephalomyelitis (EAE); however the nature of the interaction between Sn and CD4+ T cells is not well characterised. The first aim of this thesis was to investigate the upregulation of Sn ligand (SnL) on CD4+ T cells in …
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CD8+ T Cells Are Required for the Therapeutic Action of Glatiramer Acetate in Autoimmune Demyelinating Disease
… in MS patients. Using a murine model of MS, experimental autoimmune encephalomyelitis (EAE), we also demonstrated that CD8+ T cells are necessary in mediating the therapeutic effects of GA, and adoptive transfer of GA-induced CD8+ T cells resulted in amelioration of EAE, establishing a role …
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Multiple Toll-Like Receptor Agonists Act as Potent Adjuvants in the Induction of Autoimmunity
… I investigated the role that PAMPs play in Experimental Autoimmune Encephalomyelitis (EAE), an animal model of MS. Both genetic and environmental influences contribute to the pathogenesis of MS. I used various PAMPs as the environmental input to imitate infection and activate TLRs in an …
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Transcription factor regulation of T helper subset function
… we examined a model of multiple sclerosis termed experimental autoimmune encephalomyelitis (EAE). Mice that lack PU.1 expression in T cells (Sfpi1lck-/- mice) demonstrated more severe disease with attenuated recovery compared to control mice, and this was accompanied by an increase of T cells in …
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