Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 22 for “"experience-dependent plasticity"”.
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Investigating Experience-Dependent Plasticity in the Accessory Olfactory Bulb
… encounters, the accessory olfactory bulb (AOB) experiences changes in the balance of excitation and inhibition at reciprocal synapses between mitral cells (MCs) and local interneurons. The mechanisms underlying these changes remain controversial. Moreover, it remains unclear whether …
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Passive experience-dependent plasticity in mouse primary visual cortex
Stimulus-selective response plasticity (SRP) is a form of experience-dependent plasticity readily measured in primary visual cortex (V1) of mice. Chronic local field potential (LFP) recordings in layer 4 (L4) of V1 allow for the tracking of visually evoked potentials (VEPs) in response to …
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Investigation of Accessory Olfactory Interneuron Physiology and Function After Experience-Dependent Plasticity
… bulb (AOB), exhibits cellular and network plasticity in male and female mice after social experience. In the AOB, interneurons called internal granule cells (IGCs) express the plasticity-associated immediate-early gene Arc following intermale aggression or mating. Here, I sought to …
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Experience-Dependent Plasticity in the Mushroom Bodies of the Honey Bee Brain
… that modify brain structure in response to experience. The model organism under study is Apis mellifera, the European honey bee. The honey bee has a rich behavioral repertoire that can easily be studied both in the laboratory and under natural conditions. The goal of these projects is to …
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Non-invasive tuning of experience-dependent plasticity in the primary visual cortex
… cortex exhibits a remarkable capacity for experience-dependent plasticity, a feature that is predominantly confined to critical periods (CPs) during early postnatal development. In the mouse primary visual cortex (V1), ocular dominance plasticity (ODP) has served as a premier model for …
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Deficient experience-dependent plasticity in the visual cortex of Arc null mice
… suggested to play a critical role in synaptic plasticity. The goal of this thesis is to understand the workings of Arc within the visual cortex. Specifically, we ask how genetic deletion of Arc influences plasticity, and how visual response properties differ between cells types containing, and …
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Critical requirements for NMDA receptors in experience-dependent plasticity in the visual cortex
… play an essential role in many forms of experience-dependent plasticity in the visual system. NMDA receptors support the ocular dominance (OD) shift, development of receptive field properties in cortical neurons, and learning tasks associated with the visual cortex, as well as the …
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Calcium-Stimulated Adenylyl Cyclases are Critical Modulators of Fear Learning and Experience-Dependent Plasticity
… mice show changes in CF memory strength that is dependent on prior environmental exposure, but DKO mice do not, suggesting that Ca<super>2+</super>-stimulated AC activity modulates plasticity at the behavioral level as well. From these studies, I have observed a critical role for …
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Understanding experience-dependent plasticity of cellular and network activity in the mouse primary visual cortex
Sensory experiences in daily life modulates corresponding primary sensory cortices and eventually alter our behavior in a befitting manner. One of the most impactful sensory modules is vision. Primary visual cortex (V1) in mammals is particularly malleable during a juvenile critical period, but …
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Experience, neuroanatomical plasticity and expression of the immediate early gene ZENK in the visual cortex of weanling rats
… factor correlates with morphological plasticity, using a model of experience-dependent plasticity.
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Mechanisms of Olfactory Plasticity in Caenorhabditis Elegans
… threats. By gathering information from past experiences, individuals modify their behavioral response to adapt to the changing environment, a phenomenon known as "experience-dependent plasticity". This ability to change is a crucial for survival, and how an organism achieves this adaptive …
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Characterization of CPG15 during cortical development and activity dependent plasticity
… thought to be key to the translation of sensory experience into long-term changes in synaptic structure and function. Here we show that cgp15, a gene encoding an extracellular signaling molecule that promotes dendritic and axonal growth and synaptic maturation, is regulated in the somatosensory …
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Visual cortical plasticity : the role of parvalbumin expressing inhibitory neurons and abnormalities in models of neurodevelopmental disorders
… roles played by cortical inhibitory neurons in experience-dependent plasticity and learning are not well understood. Here we evaluate the participation of parvalbumin-expressing (PV+) GABAergic neurons in two forms of experience-dependent modification of primary visual cortex (V1) in adult mice: …
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In vivo visualization of CaMKII activity in ocular dominance plasticity
Alterations in sensory experience can persistently modify the responses of cortical neurons. Ocular dominance (OD) plasticity, a process in which alternation of visual input induces a shift in cortical responsiveness, is an extensively studied model of such experience-dependent plasticity. However, …
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Task oriented training and evaluation at home (TOTE Home)
… at Home (TOTE Home), incorporated current experience-dependent plasticity aspects (Kleim & Jones, 2008) modeled after the ASAP protocol parameters as described in Winstein et al. (2013) and principles of task oriented training as suggested by Lang and Birkenmeier (2014). Repeated measures …
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Inhibitory synapses are repeatedly assembled and removed at persistent sites in vivo
Structural plasticity, the rewiring of synaptic connections, occurs not only during development, but is prevalent in the adult brain and likely represents the physical correlate of learning and memory. Removal or addition of excitatory and inhibitory synaptic inputs onto a neuron can affect their …
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Metabotropic glutamate receptor 5 : a therapeutic target in Fragile X and a regulator of plasticity in visual cortex
… the role of mGluR5 in regulating synaptic and experience-dependent plasticity in wild-type mouse visual cortex. We report that NMDA receptor-dependent long-term depression (LTD) is reduced specifically in layer IV of visual cortex in mGluR5 knockout mice, as well as in wild-type mice treated …
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Investigating the role of thalamic activity in visual cortical plasticity
Experience-dependent plasticity is an integral process by which the brain learns to respond to relevant stimuli in the world. The visual cortex is a well-studied locus of such learning, exemplified by the simple yet robust phenomenon of stimulus-selective response plasticity (SRP). In SRP, neurons …
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Mechanisms of ocular dominance plasticity in the juvenile and adult mouse visual cortex
Ocular dominance (OD) plasticity is a classic example of bidirectional experience-dependent plasticity in the primary visual cortex. This form of plasticity is most robust during early postnatal development (termed the "critical period"), when monocular deprivation (MD) leads to a rapid weakening …
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