Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"exogenous agents"”.
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Multi-parametric photoacoustic/ultrasound localization (PAUL) imaging and its applications
… generation, and fully label-free imaging without exogenous agents. The multiparametric sensing capability makes PAUL imaging well-suited to capture complex biological disease processes and guide therapeutic interventions. We further demonstrated this capability through several applications: …
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EXAMINING THE ROLE OF THE XAB2 PROTEIN IN HOMOLOGOUS RECOMBINATION
… cycle during replication or transcription, or by exogenous agents such as chemicals or ionizing radiation. For my thesis, I studied homologous recombination (HR), which has two sub-pathways: Homology Directed Repair (HDR) and Single Strand Annealing (SSA). HDR involves strand invasion of a …
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Measurement of Cerebral Metabolism and Vascular Function with Magnetic Resonance Imaging
… imaging (MRI) involve special equipment and/or exogenous agents, and may not be suitable for routine clinical studies. To fill this gap, I developed a noninvasive method for quantifying whole brain CMRO2. This method uses the Fick principle of arterio-venous difference for the calculation of …
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Effect of Werner and Bloom Helicase Deficiencies On Dna Double-Strand Break Repair
… occur in cells. Causes can include endogenous agents such as reactive oxygen and nitrogen species, exogenous agents such as ionizing radiation and ultraviolet light, or other sources such as processing of spontaneous DNA lesions or collapse of stalled replication forks. The RecQ helicases are a …
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The role of the human endonuclease VIII-like 1 and 3 in the repair of DNA replication blocking lesions
… DNA inter-strand crosslinks (ICLs), arising from exogenous agents. Human NEIL1 (hNEIL1) activity on psoralen generated mono-adducts (MAs) and three-stranded DNA ICLs was previously described and recently NEIL3 from Xenopus laevis was reported to repair psoralen generated MAs and …
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Structural and Biochemical Investigation of the Molecular Mechanisms of DNA Response and Repair in Humans and <em>Escherichia coli</em>.
… under constant attack from both endogenous and exogenous agents that damage DNA. In order to maintain genetic integrity a variety of response pathways have evolved to recognize and eliminate DNA damage. Replication protein A (RPA), the eukaryotic single-stranded DNA (ssDNA) binding protein, is a …
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The role of UBZ1 in PCNA-dependent DNA damage response
… genomic material. DNA damage can be caused by exogenous agents, like radiation and toxins or by endogenous factors, like Reactive Oxygen Species (ROS), produced during normal oxygen metabolism. in order to guarantee cell survival and the transmission of the correct genetic information to their …
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The role of the BARD1 BRCT domains in the DNA damage response
… on a continuous basis by both endogenous and exogenous agents. One of the most dangerous types of damage a cell can incur are DNA Double stranded breaks (DSBs) as failure to repair these types of lesions can lead to mutations, cell death and cancer. In order to maintain genome integrity, cells …
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Identifying a transcriptional signature for cell sensitivity to the cancer chemotherapy agent, BCNU
… constant damage to DNA caused by endogenous and exogenous agents. These mechanisms activate cell cycle checkpoints to allow time for DNA repair or, in the case of severely damaged DNA, initiate cell death mechanisms to maintain genomic integrity. The cell's response to DNA damaging agents …
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EPIDEMIOLOGICAL AND FUNCTIONAL APPROACHES TO EVALUATE THE EFFECTS OF PARTICULATE MATTER EXPOSURE IN INFANTS WITH VIRAL BRONCHIOLITIS
… a fundamental role in the first response to both exogenous agents and commensal/pathobionts components of microbiota. In particular, bacterial-derived Extracellular vesicles (bEVs) are emerging as essential interregnum messengers that could play a crucial role in communication with mammalian …
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Probing Tissue Microstructure Using Susceptibility Contrast Magnetic Resonance Imaging
… growing use of paramagnetic contrast agents in magnetic susceptibility imaging motivated a series of investigations regarding the effect of these exogenous agents on susceptibility imaging in the brain, heart, and kidney. In each of these organs, gadolinium increases susceptibility …
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PARSES: A Pipeline for Analysis of RNA-Sequencing Exogenous Sequences
… biological contamination or the presence of exogenous sequences that may shed light on other factors influencing an organism's condition.