Global ETD Search
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Showing 1 to 12 of 12 for “"exocyst"”.
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Breaking the exocyst
… of cell polarity. A large protein complex, the exocyst, has an utmost important role in the polarised trafficking processes. <br/><br/>Most studies of the exocyst machinery and functions have been made by suppression of genes or deletion of a single subunit which may prevent the holocomplex …
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The Sec6/8 (a.k.a. Exocyst) Complex Supports DNA Repair Fidelity
The exocyst complex, first described in yeast, is a heterooctomeric complex that serves as a signaling platform to mediate cellular responses to diverse spatial and temporal cues. Evidence suggests that the exocyst might contribute to oncogenesis, potentially by disrupting spatial and temporal …
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Molecular mechanisms of exosome secretion
… surface of MVEs mediates the recruitment of the exocyst complex. The exocyst then targets the MVEs to the plasma membrane for exosome secretion. Disrupting PI(4)P generation or exocyst function blocked exosomal secretion of Programmed death-ligand 1 (PD-L1), a key immune checkpoint protein in …
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Molecular Mechanisms Underlying Innate Immune Kinase TBK1-Driven Oncogenic Transformation
… population of AKT is bound to components of the exocyst complex. Upon mitogen stimulation, triggering of the innate immune response, re-exposure to glucose, or oncogene activation, TBK1 is recruited to the exocyst, where it activates AKT. In cells lacking TBK1, insulin activates AKT normally, but …
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Hexagonal packing of Drosophila wing epithelial cells by the Planar Cell Polarity pathway
… Cell Polarity protein Flamingo can recruit the exocyst component Sec5. Sec5 vesicles also co-localizes with E-cadherin and Flamingo. Based on these observations we propose that during the hexagonal repacking of the wing epithelium these proteins polarize the trafficking of E-cadherin-containing …
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RalGDS-Dependent Cardiomyocyte Autophagy Is Necessary for Load-Induced Ventricular Hypertrophy
… is membrane biogenesis and processing. The exocyst, an octomeric protein complex involved in vesicle trafficking, is implicated in numerous cellular processes, yet its role in cardiomyocyte plasticity is unknown. Here, I set out to explore the role of small G protein-dependent membrane …
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Quantitative Aspects of Interface Remodeling During Germband Extension
… and final study, the functional requirements for exocyst complex function during cell division in vivo was investigated, and a common mechanism that directs anaphase cell elongation and cleavage furrow progression during cell division was demonstrated. The results of this study show that onion …
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Fucntional Analysis of Sec61beta, a Component of the Sec61 protein Translocation Channel at the Endoplasmic Reticulum
… von Gurken besitzen. Sec61b interagiert mit dem Exocyst-Komplex und Gurken benötigt den Exocyst-Komplex für seine Lokalisation zur Plasmamembran. Demzufolge könnte das Fehlen von Sec61b einen direkten Transportdefekt von Gurken bewirken. Die ectopische Expression von Sec61_ in Flügeln von …
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The Novel Role of Dnmbp In Kidney Development
… membrane vesicles, we examine the role of the exocyst-associated scaffolding protein, Dynamin binding protein (Dnmbp), during junction assembly in epithelializing nephric tubules. We show that disruption of Dnmbp affects adhesion and junctional integrity of nephron progenitor cells by …
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Rab8 Directs Tubulation and Furrow Ingression During Epithelial Formation in Drosophila Melanogaster
… membrane addition, with Sec5, a subunit of the exocyst and RalA, a small GTPase implicated in directed membrane trafficking.</p> <p>Disruption of Rab8 function results in a complete failure of furrow formation in the early embryo, due to a failure of proper F-actin cytoskeletal dynamics and …
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Common Accommodation Mechanisms for Mutualistic and Detrimental Fungi in Oryza sativa (Rice) Roots
… a new set of co-induced rice genes (Exo70-H3b exocyst, Lectin Receptor-Like Kinase, LecRLK and DUF538 genes encoding ‘proteins of unknown function) that may be commonly required for the invasion of rice roots by both symbiotic and detrimental fungi. These findings lend strong support to the …
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IDENTIFICATION OF COMMON MECHANISMS TO INTRACELLULARLY ACCOMMODATE BENEFICIAL OR PATHOGENIC FUNGI IN RICE
… specifically three genes encoding an Exo70 exocyst component, a L-type lectin receptor-like kinase (LecRLK), and a Domain of Unknown Function 538 (DUF538) protein, respectively. While none of these genes were found to be directly essential for the intracellular accommodation of either …