Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 534 for “"exhaustion"”.
-
T Cell Exhaustion in Glioblastoma
… in GBM. Severe T cell dysfunction such as T cell exhaustion is a known contributor to failures of immune checkpoint blockade, yet has not been thoroughly described in GBM. In this dissertation, we explore T cell exhaustion as a contributor to immune checkpoint blockade failure in GBM. Chapters 1-3 …
-
Mechanisms of Neutrophil Exhaustion and Resolution
… and mortality of sepsis, the cause of neutrophil exhaustion and the system to rejuvenate the dysregulated immunity are understudied. To fill in the missing piece here, we conducted our trilogy-like projects. First, we established an in vitro culture system to mimic sepsis-like conditions: murine …
-
Postmodern humanism and the "exhaustion of easy life"
1 PDF file (iii, 82 pages)
-
Pendulum V: DM "Vitality, Exhaustion and Fleeting Equilibrium"
This dissertation is in two parts: Part A is the score for the original composition, PendulumV: DM. Part B is a companion essay to the musical composition. Pendulum V: DM is a 17-minute work for large ensemble and live electronics. It was commissioned jointly by the Wet Ink Ensemble and AMP, with …
-
The indulgence and exhaustion of the meaningless voice
Includes bibliographical references.
-
John Barth, Ebenezer Cooke, and the literature of exhaustion
… must first examine his theory of "literature of exhaustion." According to Barth, this literature begins with the realization that the novel is dead or dying and uses this fact as a theme. The writers of this fiction must be aware of the history of the novel and must write technically up-to-date …
-
Weakly q-Convex Domains and Bounded q-Subharmonic Exhaustion Functions
… q-convex domains with bounded q-subharmonic exhaustion functions. Sufficient conditions for this generalized Diederich-Fornæss index to have a given lower bound are proved. We show this generalized index is positive on bounded weakly q-convex domains with C^3 boundaries. Additionally, we …
-
Emotional Exhaustion and Its Role in Service Sabotage among Boundary Spanners
… dissertation is to investigate how emotional exhaustion (EE) impacts a boundary spanning employee's usage of service sabotage behaviors (SSB). This dissertation also investigates how perceived organizational support (POS) and perceived supervisory support (PSS) alleviate a boundary spanning …
-
Climate Change and the Exhaustion of Fossil Energy and Mineral Resources
The ongoing exhaustion of fossil fuels places a limit to the total amount of anthropogenic CO2 that will be emitted into the atmosphere and therefore constraints future global warming. Here we assess the implications of fossil fuels depletion on future changes of atmospheric CO2 concentration and …
-
Targeting Innate Immune Memory to Alleviate Monocyte Exhaustion and Chronic Inflammation
… explores two parallel models of immune exhaustion and low-grade inflammation. In the first project, we reported that co-treatment of monocytes with methoxy-mycolic acid (M-MA) effectively impedes the phenotype of exhausted monocytes induced by repeated exposure to LPS, including blocking …
-
An Intrusion Detection System for Battery Exhaustion Attacks on Mobile Computers
… of denial of service attack known as a battery exhaustion attack, in which an attacker attempts to rapidly drain the battery of the device. Battery exhaustion attacks greatly reduce the utility of the mobile devices by decreasing battery life. If steps are not taken to thwart these attacks, they …
-
Impact of Hyperglycemia on Rat Cortical Bone Microstructure and Osteoprogenitor Cell Exhaustion
Uncontrolled diabetes has been associated with an increased risk of bone fracture and implant failure. However, the underlying reasons have yet to be entirely understood. Our group previously reported that osteocyte number appeared increased in the peri-implant bone of hyperglycemic rats, which …
-
The Role of TCR Engagement Strength in Antitumor CD8 T Cell Exhaustion
… results provide fundamental insight into T cell exhaustion and have important implications for the development of cancer vaccines that target tumor-epitopes with varying TCR binding avidities.</p>
-
The Politics of Exhaustion and Migrant Subjectivities: Researching border struggles in northern France in 2016-2019
… wellbeing, and self-efficacy. This ‘politics of exhaustion’ thus seeks to curb autonomous migratory movements, influence decisions, and manage intent through the physical, mental, and emotional exhaustion of its subjects. In this sense, exhaustion is understood as constitutive of bordering …
-
TOX2 and TOX at the intersection of central memory and exhaustion in human CAR T cells
… solid tumors has been limited due to T cell exhaustion, which limits their proliferation and cytotoxicity when chronically stimulated with antigen, such as in cancer. Genetic modification of CAR T cells is one approach to improve tumor killing capacity. We profiled a patient with chronic …
-
An Epidemiological Study of Exhaustion in the Context of Chronic stress. Concept, Cortisol, Causes and Consequences
The interest in exhaustion has increased rapidly during the last few decades in many developed countries. In Sweden, prevalence of exhaustion increased by 50 percent on average between 1989 and 2005, and recent data reveals that exhaustion still remains at this higher level. Scientifically, …
-
The ergogenic effect of transcranial direct current stimulation on cycling time to exhaustion task performance in physically active people.
Endurance exercise consisting of sustained whole-body dynamic exercise inevitably induces muscle fatigue, which leads to task failure. It is considered that the brain plays a key role during the regulation of endurance exercise performance. It is believed that exercise-induced muscle fatigue …
-
A novel antigen-receptor signalling reporter mouse reveals clonotype-independent intratumoral trapping as a spatial feature of CD8+ T cell exhaustion
… characteristic to the definition of T cell exhaustion. Taken together, this thesis established the utility of the AgRSR mouse in characterizing CD8+ T cell behaviours in tumours, permitting us to identify clonotype-independent invariant properties of T cell dysfunction. From the …
Page 1 of 27