Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"executioner caspases"”.
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Islet Dysfunction In Diabetes
… endoplasmic reticulum [ER] - mitochondria axis, executioner caspases and their target substrates; specifically nuclear lamins. </p> <p>Results obtained from our studies in pure beta cells [INS-1 832/13], primary rodent and human islets strongly suggest that glucotoxicity induced pancreatic beta …
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Une approche afin de produire les différentes conformations de caspase-7 tout en contrôlant l'induction de l'apoptose
… proteases that includes apoptotic initiators (caspases-8, -9 and -10) and executors (caspases-3, -6 and -7). During apoptosis, executioner caspases are cleaved by initiator caspases either by the extrinsic (death receptors) or by the intrinsic (mitochondrial) pathway of caspase activation. …
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Nanosecond Pulsed Electric Fields Induce a Mitochondria-Independent Apoptosis in B16F10 Melanoma Cells <i>In Vitro</i>
… inducing factor (AIF). Further examination of caspases with isozymes specific initiators indicated electric field-dependent increases in caspases -8 and interestingly -9 as well as executioner caspases -3, -6 and -7.</p> <p>NsPEFs activate signal transduction mechanisms that induce apoptosis …
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NEW INSIGHTS INTO THE REGULATION OF MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION DURING APOPTOSIS
… sensitive to anti-Fas. Inhibiting downstream caspases decreased all anti-Fas-induced apoptotic changes. Combined, my findings strongly suggest that Fas-mediated activation of executioner caspases and induction of apoptosis does not depend on apoptosome-mediated caspase-9 activation in …
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Investigating Apoptosis Pathway In Chronic Lymphocytic Leukemia: Stromal Influence and Therapeutic Activation
… this study involved therapeutic manipulation of executioner caspases in restoring apoptotic pathway that is frequently blocked by upstream anti-apoptotic Bcl-2 family members. A novel therapeutic approach that can potentially bypass the functional pro-survival proteins and directly activate …
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Development of PAC-1 as a privileged agent for combination chemotherapy
… Building upon the success of dual targeting of executioner caspases for enhanced apoptotic effect, PAC-1 was investigated as a method to broadly enhance diverse pro-apoptotic signals. Excitingly, increased anticancer activity was observed broadly in models of increasing complexity and clinical …