Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"excitotoxin"”.
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The GluK4 Kainate Receptor Subunit Regulates Mood, Memory and Excitotoxic Neurodegeneration
… intrahippocampal injection of kainate, a potent excitotoxin, and widespread neuroprotection throughout the hippocampus following hypoxia-ischemia. Molecular and biochemical analysis of kainate- and sham-treated wild-type and GluK4 knockout hippocampal tissue revealed that GluK4 may act through …
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Investigating neural responses in models of neurocysticercosis
… the seizure-threshold to picrotoxin, an excitotoxin, was not altered by Taenia crassiceps homogenate injection. Immunohistological analysis of the tissue below the injection site revealed no difference in astrocytes nor the number of microglia. However, microglial processes were observed …
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Asymmetric Allylation of Aldehydes Catalyzed by Formamide Organocatalysts. Studies Towards The Synthesis of L- Domoic Acid Side Chain
… in the genus Pseudo-nitzschia, is a potent excitotoxin known to cause amnesic shellfish poisoning, brain damage, and death in severe cases. Structurally, domoic acid is an analog of the amino acid glutamic acid and the excitatory neurotoxin kainic acid. The availability of these potent …
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Organelle specific mechanisms of neuronal cell death
… epilepsy and ischaemia. Glutamate is the major excitotoxin in the CNS and causes activation of glutamate receptors. Ionotropic glutamate receptors can directly cause calcium influx that further enables activation of cell death pathways. Kainic acid (KA) is a specific agonist for ionotropic …
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The effect of AAV1/2 mediated delivery of brain-derived neurotrophic factor and fibroblast growth factor-2 on adult rodent neurogenesis
… of rats by unilateral striatal injection of the excitotoxin quinolinic acid (QA) 21 days after AAV1/2 injection and 24 hours prior to BrdU labeling. The results of this thesis demonstrate that BDNF augments the recruitment, neuronal differentiation and survival of progenitor cells in both …
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Neural and psychological mediators of trait impulsivity: cortico-striatal circuitry and catecholaminergic neuromodulation
… visual attention. PFC lesions effected using the excitotoxin quinolinic acid profoundly affected performance on the 5CSRTT but had negligible effects on a signal detection attentional task. Taken together, these findings suggest that impulsive (premature) responding in the 5CSRTT is linked with …
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Kontinuierliche Überexpression von Interleukin-6 im Zentralnervensystem : lokale Applikation d. Designerzytokins Hyper-Interleukin-6 im adulten Organismus d. Ratte u. Auswirkungen v. exzitatorischen Neurotoxinen im Interleukin-6 transgenen Mausmodell
Im ersten Teil der vorliegenden Arbeit wurde ein Modell zur langfristigen, kontinuierlichen Expression des Designerzytokins Hyper-Interleukin-6 (H-IL-6) im <br>Zentralnervensystem (ZNS) entwickelt. H-IL-6 besteht aus humanem Interleukin-6 (IL-6) verbunden mit löslichem IL-6 Rezeptor (sIL-6R). …