Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 36 for “"excitatory neurons"”.
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Translational Regulation in Excitatory Neurons Controls Stress Reactivity and the Antidepressant Response to Ketamine
… thesis examines the role of 4E-BP signalling in excitatory forebrain (Camk2a-positive) neurons in behavioural and endocrine responses to acute (ARS) and chronic (CVS) stress, and in ketamine's antidepressant effect. We found that ARS increased grooming and corticosterone in both sexes, with …
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Analysis of activity-dependent morphological plasticity of dendritic spines on hippocampal neurons
… spines are the main sites of synaptic input onto excitatory neurons. As recent experiments showed that synaptic activity and especially long-term potentiation (LTP) can modify spine morphology and number, I studied the effect of long-term depression (LTD) on these parameters. I used a local …
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Understanding the nervous system as an information processing machine: dense, nonspecific, canonical microcircuit architecture of inhibition in neocortex . . .
… circuitry, specifically on how inhibitory interneurons connect to excitatory neurons. Chapter 2 focuses on the algorithmic problem of how flies could use gyroscopic sensors to calculate angular velocity.
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Hippocampal microcircuits for social memory specification
… Both the inhibition of GABAergic inhibitory neurons in CA2 and reduced activity of excitatory neurons by ablation of oxytocin receptors in the dCA2 to vCA1 microcircuits impair social memory specification. These results suggest that the vCA1 and the multiple feed-forward inhibition motifs in …
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Dynamics of a fully stochastic discretized neuronal model with excitatory and inhibitory neurons
… network of discretized integrate-and-fire excitatory neurons where synapses are failure-prone. It was shown that this model exhibits different metastable phases of asynchronous and synchronous behavior, since the model limits on a mean-field deterministic system with multiple attractors. …
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Mechanisms of DNA double strand break-mediated neurotoxicity in neurodegenerative disease
Neurons are highly susceptible to DNA damage accumulation due to their large energy requirements, elevated transcriptional activity and long lifespan. DNA double strand breaks (DSBs) are also linked to neurodegeneration and senescence. However, it is not clear how DSB-bearing neurons influence …
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Transcriptomic Signatures of Projection Class Neurons for Vocal Control
… to identify long-range projection classes of neurons, assess transcriptional markers, and make cross-species comparisons. In the marmoset, I identified layer 5 extratelencephalic-projecting (L5 ET) excitatory neurons of orofacial and hindlimb primary motor cortex. Compared to L5 ET hindlimb …
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Investigating gene expression differences in acute and organotypic mouse hippocampal brain slices as models for studying the brain
… expressed genes across major cell types, with excitatory neurons and astrocytes showing the most substantial transcriptional changes. Gene ontology analysis demonstrated upregulation of pathways involved in neuronal development and cell signalling alongside downregulation of axon guidance …
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The Effects of PTEN Deletion on Cell Size and Plasticity in the Hippocampus
… neuronal migration and substantial hypotrophy of neurons and synaptic densities. However, whether its effect on synaptic transmission and plasticity is direct or mediated by structural abnormalities remains unknown. Here we analyzed neuronal and synaptic structures and function in Pten-conditional …
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Using single nucleus RNA-seq to determine the effect of immunosuppression on the transcriptional activity of resident CNS cells in a mouse model of CNS-TB
… most DEGs in the general TB response, whereas excitatory neurons had the highest DEGs in the immunocompromised TB response and with disease progression. Potential mechanisms by which these cell types contribute to the pathogenesis of CNS-TB were explored, such as excitotoxicity, demyelination …
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Genomic studies of motif enrichment and conservation in the regulation of gene expression in the brain
… been shown to fall under the control of MEF2 in excitatory neurons.
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Building cell assembly based associative memory with spiking neurons
… in synaptic conditions and strength between neurons. This thesis explores networks of spiking neurons to implement CAs and to simulate cognitive functions. The Stroop test, a prominent cognitive interference task, is replicated in a task-completion simulation using binary CAs. Additionally, a …
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Molecular mechanisms of synaptic plasticity
… calmodulin in the postsynaptic compartments of excitatory neurons. Dysregulation of neurogranin has been reported to cause altered synaptic plasticity as well as impairment in hippocampus-dependent learning, and is also associated with the higher risk of developing neurodegenerative and …
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Modulation of Excitatory and Inhibitory Neuronal Balance Through Regulation of Ptf1a by Factors Binding to Zinc Finger and POU Motifs
… system depends on a delicate balance between excitatory and inhibitory neurons. Transcription factors of the basic helix-loop-helix (bHLH) family have been shown to be particularly important in generating the correct numbers of these neurons during development. One of these, Ptf1a, is required …
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Gamma frequency entrainment attenuates amyloid load and modifies microglia
… between fast-spiking (FS)-parvalbumin (PV)-interneurons and pyramidal cells. Changes in gamma oscillations have been observed in several neurological disorders. However, the relationship between gamma oscillations and cellular pathologies of these disorders is unclear. Here, we investigated this …
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Inhibitory Control of Contextual Fear Memory and Memory Specificity
… brain is mainly achieved by GABAergic inhibitory neurons which exert their effect by acting on multiple types of GABA receptors. In this dissertation, I examined the roles of specific types of GABAergic neurons and GABA receptors in learning and memory. The study consists of three major …
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Optogenetic Interrogation of Primary Visual Cortex and Its Impact On Neural Coding and Behavior
… activity of large populations of interconnected neurons, but while the responses of individual neurons to a variety of sensory stimuli have been well-characterized, how <em>populations</em> of such neurons organize their activity to create our sensory perceptions is almost entirely unknown. To …
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Deep Molecular Characterization of Human Cortical Cell-Types
… layer 5a, as well as layer 6a, and layer 6b excitatory pyramidal neurons, VIP, LAMP5, RELN, and PVALB expressing interneurons, astrocytes, microglia, oligodendrocytes, and OPCs. We show that our isolation strategy is highly cell-type specific and reproducible, permitting deep molecular …
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Regulation of Memory by the Actin-Binding Protein Cofilin
… of transgenic cofilin was robustly localized in excitatory neurons and processes in both mouse models. However, rod-like structures thought to be cofilin-actin aggregates were observed in cofilin overexpressing mice. I then showed that cofilin overexpression impaired short-term social novelty …
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An Examination of the Mechanisms of Neocortical Network Excitability in a Mouse Model of Fragile X Syndrome
… occur synchronously throughout local neocortical neurons. UP states arise from local recurrent connections and are regulated by intrinsic neuronal properties. As such, measurement of UP states provides insight into overall circuit properties. Furthermore, I observe that the increase in UP state …
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