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Showing 1 to 20 of 29 for “"excitation-contraction coupling"”.
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Cellular Calcium Movements and Excitation-Contraction Coupling in Guinea Pig Atria
… When the tissue had reached a steady-state of contraction strength, rest intervals of 1 minute were introduced and the changes in the paracellular calcium levels were measured with the calcium sensitive micro-electrodes. The control condition produced an average increase during the interval in …
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Effects of magnesium and calcium upon excitation-contraction coupling in the heart
… primary factor determining the force of cardiac contraction. An intracellular organelle, the sarcoplasmic reticulum (SR), regulates the relaxation of the muscle as well as acting as a source of activating Ca2 during excitation-contraction coupling. Calcium metabolism in the heart undergoes …
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Excitation-Contraction Coupling: Analysis of Calcium Storage Sites in Guinea Pig Atrium
Made available in DSpace on 2014-12-11T22:22:22Z (GMT). No. of bitstreams: 1 7412017.pdf: 5610525 bytes, checksum: 3da4363a2a281c4a6f8070782e9412d0 (MD5) Previous issue date: 1973
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Excitation-Contraction Coupling: The Effect of Calcium Channel Antagonistic Drugs on Reprimed and Inactivated Skinned Skeletal Muscle Fibers
Contracture of skinned (sarcolemma removed), skeletal muscle fibers can be elicited by sudden changes in the ionic composition of the myoplasm. The bulk of evidence in the literature suggests that such contracture of skinned fibers is triggered by depolarization of resealed transverse tubules. If …
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A control model of muscle contraction
… that are currently thought to cause a muscular contraction. The model is developed with the hypothesis that a series of disturbing signals (or inputs) simply propagate faster than the respective controlling signals can correct for them. Transfer functions for each system are developed, with …
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Investigating the Impact of K+ Channel Expression on Mechanosurveillance of Disseminated Cancer Cells
… potassium efflux in promoting relaxation during excitation-contraction coupling. In a striking contrast, however, KCNMB1 knockdown decreased cellular stiffness in cancer cells. Softer cancer cells were resistant to NK cell-mediated cytotoxicity and the low KCNMB1 expression was associated with …
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Calcium Influx via the T-Type Calcium Channel Plays a Permissive Role in Proliferation of Mouse Embryonic Hl-1 Cells
… through the L-type channel is responsible for excitation-contraction coupling in the heart. The T-type calcium current has been associated with growth and differentiation in a number of different cell types. An atrial myocyte cell line (HL-1) that selectively expresses T-type calcium current …
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Up-regulation of junctophilin-2 prevents ER stress and apoptosis in hypoxia/reoxygenation-stimulated H9c2 cells
… the proper Ca2+-induced Ca2+ release for stable excitation-contraction coupling. Down-regulation of JPH2 has been observed in diseased hearts and is related to cardiac dysfunction and T-tubule remodeling. In this study, we show that the protein levels of JPH2 are down-regulated in cardiomyocytes …
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Expression of myofibroblasts and identification of angiotensin receptors in capsular contracture disease around mammary implants
… disease characterised by fibrosis and contraction of the breast capsule in women with implants. There is evidence that Angiotensin-II (Ang-II) is implicated in pathological wound healing and that blockers of Ang-II may prevent fibrosis. Capsules from 12 breasts excised from eight …
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Effects of Heregulin on Muscle: A Biochemical and Histological Analysis
… the mechanical rigors involved with muscle contraction leading to progressive muscular dystrophy. Heregulin/neuregulin-1 (HRG), a member of the epidermal growth factor family has been shown to induce neuromuscular junction (NMJ) gene expression in vitro and improve skeletal muscle function …
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Modulations of calcium binding and of energy coupling by the calcium pump of sarcoplasmic reticulum
… during relaxation and releases cav2 + during contraction. This highly differentiated endoplasmic reticulum is a self-contained network with a continuous hollow interior which surrounds each muscle fibril (Fig. 1) (Porter, 1961). The SR is fragmented at longitudinal intervals of one sarcomere …
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DYSREGULATION of PROTEIN QUALITY CONTROL IMPAIRS FUNCTION of PRIMARY CARDIOMYOCYTES
… provide the main energy required for cardiac excitation-contraction coupling via aerobic oxidative phosphorylation (OXPHOS) process. Accumulation of reactive oxygen species (ROS), by-products of mitochondrial respiration, within dysfunctional mitochondria results in the activation of cardiac …
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Ankyrin-B and Mtor Complex 1 In The Regulation of Electrical Activities In The Heart
… calcium ion homeostasis, which underlies normal excitation-contraction coupling. Sustained mTORC1 activity in the heart decreases the expression of ankyrin-B and alters the electrical conductance between the atria and ventricles. These effects are reversed with the administration of the mTORC1 …
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T-type Calcium Channels in Arterial Smooth Muscle: Activity, Regulation and Function
… Ca2+ channels (CaV) are key regulators of excitation-contraction coupling in arterial smooth muscle. Despite evidence of T-type CaV channels in rodent smooth muscle, little is known of their regulation and function. This thesis sought to delineate T-type Ca2+ channels, ascertain if they are …
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Discovery and Characterization of Genes Involved in Muscle Calcium Handling
… release and clearance to generate and sustain contraction. When the plasma membrane of a muscle fiber becomes electrically excited, a voltage sensor in the membrane, called the dihydropyridine receptor (DHPR), becomes activated and signals to the calcium release channel located in the membrane …
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Spatial organization of sodium calcium exchanger and caveolin-3 in developing mammalian ventricular cardiomyocytes
… cardiomyocytes, the established mechanism of excitation-contraction coupling is calcium-induced calcium release (CICR) mediated by L-type Ca2+ channels (Cav1.2). Briefly, membrane depolarization opens voltage-gated Cav1.2 to allow for the influx of extracellular Ca2+ into the cytosol. This …
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The effects of angiotensin-converting enzyme inhibitors as a pharmacological treatment for Dupuytren’s disease
… of the hand associated with fibrosis and contraction of the fascia of the palm, leading to stiffness and inability to properly flex and extend the digits. The disease is caused by both genetic and environmental factors. There is some evidence that Angiotensin II (ANGT II) may be associated …
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Diabetes and the Female Heart
… energetics, and structure, focusing on cardiac excitation contraction coupling (ECC) - a critical cellular event that leads to heart muscle contraction. To achieve the project aim, I developed and applied an integrated experimental pipeline combining diabetic rat preparation, work loop …
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