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Showing 1 to 20 of 74 for “"excipient"”.
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Grewia polysaccharide gum as a pharmaceutical excipient
… physicochemical characterization of candidate excipients forms an essential step towards establishing suitability for pharmaceutical application. For natural gums, this usually requires isolation of the gum from the storage site by extraction processes. Grewia polysaccharide gum was extracted …
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An investigation into polymeric excipient-drug compatibility in solid-liquid formulations
… 1.1, 1.4 and 1.0µm respectively. The polymeric excipients chosen for this investigation were the water-soluble polymers hydroxypropylmethylcellulose (HPMC), hydroxyethylcellulose (HEC), carboxymethylcellulose (CMC), gum arabic (GA), guar gum (GG) and lambda-carrageenan (l-carrageenan). The …
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Modified starch as an excipient for pellets prepared by means of extrusion/spheronisation
De focus van dit onderzoeksproject zijn pellets als farmaceutische doseringsvorm. Pellets worden gedefiniëerd als sferische partikels met goede vloei-eigenschappen en met een nauwe deeltjesgroottedistributie (voor farmaceutische toepassingen variërend tussen 500 en 1500 μm). Als multiparticulaire …
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Assessment of a marine polysaccharide for use as excipient in pharmaceutical hot-melt extrusion
… derived from brown seaweed, as a polymeric excipient for pharmaceutical HME is explored. Keltone is insoluble in acidic pH and soluble in basic pH, therefore making it suitable for intestinal drug release. The processability of Keltone by extrusion using water and Eudragit EPO as …
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Dynamics and Phase Behavior of Mixed Antibody-Excipient Adsorption at an Air/Water Interface
<p>Monoclonal antibodies (mAbs) have become a leading candidate for oncological therapeutics due to their unparalleled selectivity. Monoclonal antibodies are amphiphilic, containing polar and nonpolar amino acid residues on their biomolecular surfaces. Their amphiphilic nature drives mAbs to …
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Biopharmaceutic and Pharmacokinetic Studies of Sucrose Acetate Isobutyrate as an Excipient for Oral Drug Delivery.
… here focused on investigating SAIB as an excipient, or delivery vehicle, for use in oral delivery of several drugs, including ibuprofen, saquinavir, and clarithromycin. Dissolution experiments were conducted using both ibuprofen and caffeine, and results suggest that SAIB can be used in …
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Batch foaming of hot melt extruded excipient/disintegrant/API pharmaceutical formulations and the study of the effects of the resulting cellular structures on API dissolution
… immediate release system composed of a polymer excipient and an Active Pharmaceutical Ingredient (API). Indomethacin (INM) is used as model API; Eudragit EPO (EPO) is used as polymer excipient; AcDiSol and Crospovidone (Cros) are used as two kinds of disintegrant. The main objectives are to gain …
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The design and manufacture of immediate-release optimal solid dosage forms
… solid dosage forms, from drug substance and excipient are: blending, wet granulating, drying, milling and screening, blending, tableting, coating, and so on. A new process, such as blending combined with solvent-less, multi-component injection-molding could greatly simplify manufacturing. …
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Effects of API particle size on the dissolution rate in molten polymer excipient matrices during hot melt extrusion, conducted in a co-rotating twin-screw extruder
… size on the dissolution rate in the polymer excipient during hot melt extrusion is investigated using a co-rotating twin-screw extruder with three different screw configurations. Acetaminophen (APAP) and amphiphilic polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer …
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Tabletability Flip of Drugs upon Formulation
… confirmation of the predicted TFP with a soft excipient and its absence with a hard excipient for two APIs. The BS-dominating mechanism was confirmed through systems containing an excipient much softer than both API forms, demonstrating the dominating role of BS in TFP by minimizing …
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Development of a Kinetic Model to Investigate the Effect of Compositional Variation and a Processing Condition on the Solid-State Degradation of Gabapentin
… that physicochemical properties of the excipients and compaction pressure will accelerate the solid-state degradation of gabapentin, increasing the kinetic rate constant for lactam formation. To test the hypotheses, binary mixtures and compacts of gabapentin with different excipients …
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Modification of natural hydrophilic polymers for use in pharmaceutical formulations
… of the salient properties of pharmaceutical excipients, chitin, metal silicates and sugar alcohols in order to give a scientific background/context to the research subject matter reported in subsequent chapter of the thesis. When chitin is used in pharmaceutical formulations processing of …
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Perichromism: a novel technique to distinguish between amorphous and crystalline material
… being freeze-dried, and the resultant amorphous excipient, with probe incorporated, was split into eight equal masses. The samples were then stored at controlled temperature and at a relative humidity unique to each sample. After storage for one week under these conditions, visual inspection of …
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Dissolution kinetics of model api in molten polymer excipients during batch processing
… thermal degradation of the polymer (and/or other excipients) and API are major concerns in the pharmaceutical HME process: researchers aim to dissolve the total loading of the API into the excipient within the short residence time with minimal API degradation. Therefore, the kinetics of the …
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Clarithromycin nanocrystals for high-dose inhalation
… methylcellulose (HPMC) served as a dual-function excipient, stabilising nanocrystals during milling and acting as the spray-drying matrix, enabling low excipient load. Adding a citric acid/NaOH buffer (pH 5) markedly improved nanocrystal redispersibility in simulated lung fluid. The optimised …
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The kinetics of drug dissolution in polymers during hot-melt extrusion
… are mixed with water soluble polymer excipient particulates and fed in the extruder, where the polymer is melted, after which the drug particulates begin to dissolve into the polymer melt. Extrusion-generated mixing accelerates dissolution process. One issue concerning the …
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Development of paediatric dosage forms of furosemide using the problem structuring method of morphological analysis
… determination, surface tension measurement, drug-excipient compatibility studies using FTIR and NMR, viscosity determination, thermodynamic stability assessment and determination of shelf-life via accelerated and long-term stability studies. The optimum composition of the furosemide microemulsion …
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Engineering composite particles to overcome the poor pharmaceutical performance of paracetamol
… solvents), and the combination of drugs and/or excipient impact the mechanical properties of paracetamol. The mechanical properties were investigated by applying blending, freeze drying, milling, batch cooling crystallisation, solvent evaporation and cocrystals formation, while, modifying the …
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Design of oral insulin tablet formulations to enable manufacture and storage under ambient conditions
… humidity. The research systematically examined excipient selection and processing approaches to enhance the stability of amorphous glasses. Initial studies focused on binary sugar–polymer systems to establish principles of glass stability. Sucrose proved superior to trehalose (which …
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