Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 79 for “"exacerbations"”.
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Ambient particulate matter as a trigger for acute exacerbations of asthma
… matter have been associated with acute exacerbations of asthma. The mechanism(s) by which non-allergic stimuli such as particulate pollutants trigger exacerbations of allergic asthma are unknown, but may involve injury to airway epithelial cells (AEC) via oxidative stress. Objective: To …
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Understanding and predicting pulmonary exacerbations in Cystic Fibrosis using Machine Learning
… in respiratory symptoms - termed acute pulmonary exacerbations (APEs) - cause cumulative damage to the lungs, and are the most significant driver of mortality and morbidity in CF. However, despite this, currently little is known about their pathophysiology, nor what triggers them. The ability to …
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Understanding and predicting acute pulmonary exacerbations in adults with cystic fibrosis
… Understanding and predicting acute pulmonary exacerbations in adults with cystic fibrosis Dr Emem-Fong Ukor Cystic fibrosis (CF) is the most common, inherited, life-limiting, multi-system disorder among the Caucasian population. Disease arises from mutations in the cystic fibrosis …
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Exacerbations, health status and sibling pair comparisons in severe Alpha-1-Antitrypsin Deficiency
… airflow obstruction. The current work defines exacerbations, lung function and health status in these patients including sibling pairs. Exacerbations occur commonly in AATD and are associated with worse health status. Exacerbations were associated with a decline in the gas transfer of the lung …
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The effect of smoking on the severity of mechanisms of acute exacerbations of COPD
… a prevalence of 10% in men and 8.5% in women. Exacerbations of COPD account for approximately 10% of all acute medical admissions. Projected prevalence figures suggest that by 2020 COPD will be the third leading cause of mortality worldwide thus imposing a significant burden on healthcare …
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Characterisation of exacerbations in non-CF Bronchiectasis to establish endpoints in measuring treatment efficacy
… productive of mucopurulent sputum and frequent exacerbations. We have aimed to validate clinical, biochemical and microbiological endpoints to aid planning of future interventional studies. We recruited fifty-eight subjects with bronchiectasis at the Lung Defence unit (Papworth Hospital, …
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The effect of smoking on the severity, and mechanisms of acute exacerbations of chronic obstructive pulmonary disease (COPD)
… prevalence of<br/>10% in men and 8.5% in women. Exacerbations of COPD account for<br/>approximately 10% of all acute medical admissions. Projected prevalence<br/>figures suggest that by 2020 COPD will be the third leading cause of mortality<br/>worldwide thus imposing a significant burden on …
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The effect of genetic variation on asthma severity and treatment in childhood
… in terms of relevant history, medication use and exacerbations. 2. My thesis presents observations reported for the first time that asthmatic children and young adults homozygous for the Arg16 allele on the ß2 adrenergic receptor gene (ADRB2), on frequent doses of on demand short-acting …
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The Effects of Pregnancy on Systemic Lupus Erythematosus
… Controversy exists about the occurrence of exacerbations during pregnancy and the effect these exacerbations will have on the basic disease process. The purpose of this study was to investigate the effect pregnancy would have in precipitating exacerbation of disease activity. The …
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Childhood Asthma Deaths in North Carolina: 1999-2012
… can be reversed with medica l therapy. With exacerbations of asthma, the goblet cells of the airway mucosa also relea se mucous secretions into the airways, which can further obstruct the airway lumen. Severe exacerbations of asthma with significantly reduced airflow can potentially compr …
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Exacerbation and glucocorticoid toxicity profile in patients receiving mepolizumab for severe eosinophilic asthma
… characteristics of the residual asthma exacerbations that occur in patients with severe eosinophilic asthma treated with anti-IL5 monoclonal antibodies?<br/><br/>2. To quantify toxicity associated with OCS treatment in severe eosinophilic asthmatics, and assess change in OCS-related …
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IMPACT OF SARS-COV-2 RESPIRATORY INFECTION ON CLINICAL OUTCOMES AND NEED FOR NON-INVASIVE VENTILATORY SUPPORT IN ACUTE EXACERBATIONS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE: A SINGLE-CENTER, PROSPECTIVE, OBSERVATIONAL STUDY
… bacterial infections are the main cause of COPD exacerbations, accounting for 25% and 26% of cases respectively. To date no conclusive data are available on the risk of COPD exacerbations triggered by SARS-CoV-2. The present study was primarily aimed to identify the risk of acute respiratory …
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FUNCTIONAL CHARACTERISATION, DISEASE BURDEN AND PREDICTORS OF MORTALITY IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE: PRELIMINARY RESULTS FROM THE ITALIAN COPD REGISTRY
… Patients with COPD are at increased risk of exacerbations, hospitalizations and mortality, but although over the years numerous severity classification systems have been proposed, they often revealed to be poorly associated with clinical outcomes. The degree of disease burden, the role of …
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Evaluation of immunomodulatory mediators in chronic obstructive pulmonary disease and cardiovascular disease
… COPD patients, 140 COPD patients with recorded exacerbations at baseline and 146 healthy controls, to evaluate the differences in circulating levels between the groups. Resolvin D1 levels were significantly lower in stable COPD patients compared with COPD patients with exacerbations at baseline, …
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Reducing Annual Emergency Department Visits Through Improved Asthma Discharge Teaching
… an impactful role in the triggering of asthma exacerbations (Harper et al., 2015). Current emergency department (ED) ideology focuses on symptoms management, with little time spent on education, and virtually no attention paid to the home environment. Evidence shows that programs which …
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Best-Practice Evidence Based Medicine for the Effective Management of Chronic Obstructive Pulmonary Disease (COPD)
… care results in a reduced rate of COPD exacerbations, improving hospital utilisation and patient related outcomes. Despite this, uptake and adherence to guidelines remains variable in practice and interventions that address this are desirable. The research undertaken in this thesis aims …
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Novel methods within a randomised controlled trial in respiratory disease
… within the new standardised EMBARC framework for exacerbations and novel Studies Within A Trial (SWAT) to increase patient recruitment and retention. A systematic review was also completed for the use of mucoactives in acute respiratory failure, which together with the other methods explored in …
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