Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 29 for “"ex-vivo model"”.
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An Ex Vivo Model For The Assessment Of Drug Toxicity On The Human Retina
… of this research were therefore to develop the ex vivo human retina as a suitable model for the assessment of retinotoxicity, and to explore the methods in which this may be investigated. Methods: Post mortem and living donor human eyes were obtained, and the retinas dissected within 24h post …
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Establishing an ex vivo model of acanthamoeba keratitis and investigating the phenotypic similarities between the protozoan acanthamoeba and human macrophages
… in the immunocompromised. In this study, an ex vivo model of AK was developed to better understand the pathophysiological processes that occur in this disease. The model has several applications such as studying the interaction of Acanthamoeba with cells of innate immunity, investigating the …
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Modulation of immune responses by human paraininfluenza virus
… respiratory pathogen was undertaken. A human ex vivo model of viral infection was developed. Priming by HPIV3 was compared to immune responses induced by influenza A virus, which unlike HPIV3 primes immunity to reinfectionwith the same strain. HPIV3 infection generated potent and mature …
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Determinants in the pandemic H3N2 influenza A virus hemagglutinin that affect receptor binding and transmission in the pig
… thesis waren vooreerst de optimalisatie van een ex vivo model van het respiratoir stelsel van het varken. Anderzijds wilden we meer inzichten verkrijgen in influenzavirus-gastheer interacties in het varken, in het bijzonder deze bepalend voor replicatie en transmissie. Hiertoe werd gebruik …
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Precision-cut placental slices as a model to study inflammatory response
… Název diplomové práce: Placentární řezy jako model pro studium zánětlivé odpovědi. Zánět probíhající v těle matky je rozpoznaným faktorem spojeným s řadou komplikací a potenciálními riziky pro neurovývoj a neuropsychiatrické faktory potomků. Centrálním prvkem této dynamiky je placenta, klíčové …
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Kultivace kožních štěpů jako modelů pro výzkum bariérové funkce kůže
… Petra Kašparová Title of the thesis: Human skin explants as models for research of skin barrier functions The skin protects the human organism from harmful environmental effects and maintains the stability of the internal environment of the human body. The protective function is considered the …
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Novel insights into fibre and lipid substrates on the microbiome
… on the human gut microbiota using in vitro, in vivo and in silico methods. Attempts were made to characterise the effects of these dietary components on gut microbiota composition from an alternative perspective in relation to human health; how they impact colonisation resistance against …
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Targeting heart rate as a novel therapeutic approach in acute heart failure
… treatment for heart failure improves cardiac remodelling and survival in the setting of chronic heart failure, but is suboptimal in cases of acute heart failure (AHF). Peripartum cardiomyopathy (PPCM), de-novo hypotension (often due to haemorrhagic shock), and Takotsubo cardiomyopathy (TC) are …
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STUDY OF THE MUTUAL INTERACTION BETWEEN EXTRACELLULAR MATRIX AND CELLS IN PERITONEAL METASTASIS
… biomechanical interaction of cancer cells with extracellular matrix extracted from human patients during peritoneal metastasis. AFM microscopy with large colloidal probes was used as the main experimental tool. Presented results of mechanical characterization of ECM, together with additional …
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The Discovery and Development of Thienopyrimidines as Inhibitors of Helicobacter pylori
… of the thienopyrimidines against H. pylori was examined through the synthesis of 27 analogs, efforts that merged elements of the two scaffolds. The resulting leads, including compound 25, demonstrate high potency with an acceptable cytotoxicity profile against the human FaDu cells. Mode of …
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MRGX1-TRPAI in inflammatory pain signalling
… pain relief, mainly because of its restricted expression in nociceptors. To date however, the role MRGX1 plays in inflammatory pain regulation in humans remains unclear as functional nociceptors from humans are not available and rodents do not harbour MRGX1-encoding genes. Here, we generated in …
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ASSESSMENT OF ANTIBACTERIAL EFFECT AND FLOWABILITY OF BIOCERAMIC SEALER MODIFIED WITH BaTiO3 NANOPARTICLES
… antibacterial evaluation was performed using an ex-vivo model. Single-rooted extracted teeth were instrumented, and canals were infected with Enterococcus faecalis for 7 days. Following the root canal treatment, the sealers (BC, BC+ BaTiO3-5%, BC+ BaTiO3-10%) were used for obturation. Untreated …
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Dose-banding studies on oxaliplatin
… of studies were included in this thesis: an extended stability study on oxaliplatin infusions using a sequential temperature cycling design; studies on oxalate, a potential degradation product and metabolite of oxaliplatin which has been linked to oxaliplatin neurotoxicity and the development …
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Prevalence and control of Clostridium difficile in patients with cystic fibrosis
… antimicrobial against C. difficile in an ex-vivo model of the human distal colon. Despite reducing viable C. difficile by 1.75 logs over 24 hours, this bacteriophage was not suitable due to its lysogenic nature. Following treatment, all surviving C. difficile were immune to reinfection due …
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Harnessing the bacteriocin-producing capacity of the gut with a view to controlling microorganisms that have been associated with obesity and related metabolic disorders
Obesity is a complex syndrome associated with a number of serious implications for human health. The gut microbiota in obesity and related metabolic conditions has received considerable attention. The aim of this project was to (1) harness the bacteriocin-producing capacity of the gut and (2) …
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Effect of Maternal Hypoxia on the Cerebral and Cardiac Tissue Remodeling
… hypoxia causes reprogramming of MMPs and TIMPs expression patterns and activities leading to aberrant brain and heart development in the fetuses and neonates. In the first part of project, we tested the hypothesis that maternal hypoxia increases the activity of MMPs and decreases the expression …
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Human leptomeninges; inflammatory roles in motor neuron disease, and their potential in gene therapy
… furthering the understanding of CNS, in the contexts of health and disease. This thesis presents post-mortem human leptomeningeal explants as an ex vivo model to explore human leptomeninges. The suitability of the model was established by assessing cell composition and tissue health. Cell markers …
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Testing metabolic and pharmacological agents for recovery following de novo acute heart failure in an isolated rat heart model
… effective therapy. Using an isolated rat heart model, we established and validated a model of de novo acute heart failure to study novel putative cardio protective therapies against acute heart failure, including glucose, insulin and the molecular agent sphingosine-1-phosphate(component of high …
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ASSESSMENT OF PERI-IMPLANT BONE MICROARCHITECTURE IN D4 BONE: AN EX VIVO MICROCT ANALYSIS
… and Tissue Level (TL). Materials and Methods: An ex vivo model utilizing porcine tibia bone was employed. A total of 33 osteotomies were performed and implants were placed following the manufacturer’s recommendations. PIT was measured using a precision digital torque meter, and ISQ was recorded …
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Evaluating substrate utilisation to target newly identified health-promoting gut bacteria
… to advance in recent years and has also expanded in response to the identification of new target species, such as Akkermansia muciniphila, Eubacterium rectale, Faecalibacterium prausnitzii, Roseburia inulinivorans, and Ruminococcus bromii, many of which produce metabolites that can …
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