Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 45 for “"evolvability"”.
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Evolution, Evolvability, Expression and Engineering
… that answer questions about: (a) Evolution & Evolvability and (b) Expression. In the first part of this thesis, I present a framework for understanding and engineering biological sequences, and solving sequence→function problems by building ‘Complete Fitness Landscapes’ in sequence space. This …
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A normative approach to designing for evolvability : methods and metrics for considering evolvability in systems engineering
… are not the only factors driving the need for evolvability; changes in requirements and context can also lead to the need for redesign. This research looks to characterize evolvability, propose design principles for evolvability, determine the conditions that make designing for evolvability …
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Empirically characterizing evolvability and changeability in engineering systems
… a system's "ilities" such as changeability, evolvability, and survivability. These ilities may enable systems to respond to perturbations in the design space, context space, and needs space in order to ensure system functionality and adequate performance over time. A system may be designed to …
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Evolution of circuits in hardware and the evolvability of artificial development
… various experiments are shown to demonstrate the evolvability of the new developmental system. A thorough investigation is then undertaken in order to obtain large amounts of empirical data that yields a better understanding of some of the crucial developmental mechanisms and parameters on the …
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How codon choice determines evolvability and evolutionary robustness in short linear motifs
… In other words, some sequences have higher motif evolvability. The simulations also indicated a fitness benefit to use some codons over others to encode linear motifs, due to the varying propensity to evolve. These findings suggest that motifs that are encoded by specific codons have higher motif …
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Evolvability of a viral protease: experimental evolution of catalysis, robustness and specificity
… later populations. Lastly, I investigate how evolvability towards new substrate specificities changed along these neutral lineages, dissecting the different determinants of immediate and long-term evolvability. Results demonstrate the utility of evolutionary understanding to protease …
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Artificial evolution with Binary Decision Diagrams: a study in evolvability in neutral spaces
… Binary Decision Diagrams, and uses it to study evolvability issues. For reasons that are not yet fully understood, current approaches to artificial evolution fail to exhibit the evolvability so readily exhibited in nature. To be able to apply evolvability to artificial evolution the field must …
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Engineering developable miniprotein ligand scaffolds
… a protein’s viability as a product – and evolvability – the capacity to accept mutations necessary for novel function. To tackle this challenge, we evaluated the ability of hyperstable synthetic miniproteins, originally designed for stability, for their potential as binding scaffolds. We …
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Exploring protein fitness landscapes with new high-throughput technologies
… with a high potential for evolution, a high ‘evolvability’, speeding up protein engineering. In this study, high-throughput technologies will be developed that enable the read-out of directed evolution on a large scale, tracking the exploration of the valley of a fitness landscape: the …
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Towards an Information Theoretic Framework for Evolutionary Learning
… the key factors influencing heritability and evolvability. We argue that heritability and evolvability of our information theoretic indicators are high. We illustrate use of our indices for reproductive and survival selection. We develop algorithms to estimate information theoretic quantities …
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Modelling morphogenesis as an amorphous computation
… properties, like robustness, regeneration, and evolvability, that are present in biological systems but ordinarily not present in computer systems. Consistent with the theory of facilitated variation from evolutionary biology, we find that many of these properties can be introduced and conserved …
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Structural Properties of Genotype-Phenotype Maps: Models, Estimates and Evolution
… positive correlation between the robustness and evolvability of phenotypes. By introducing analytically tractable models of GP maps, this positive correlation is shown to emerge from non-local effects of mutations on sequence constraints. Genotypes mapping to the same phenotype are usually …
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Applying an uncertainty-based acquisition strategy framework to select an appropriate approach for new product or system in the Military
… in a product or system is a method to foster evolvability which can sustain value delivery to its stakeholders in a feasible time and cost-effective way after the product or system has been fielded. This research and subsequent findings develop a foundational framework that was tested and …
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Investigating Modular Structure and Function in Biology: from Immunology to Cognition
… capabilities. It affords a system greater evolvability, efficiency, and robustness to perturbation; however, depending on the function being carried out, lower modularity is sometimes more advantageous, as it does not constrain the system to a particular configuration. The interactions …
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Insect Development and Evolution: Perspectives on Individual and Colony-Level Phenotypes
… highlight the species’ capacity for phenotypic evolvability. I then detail how changes in Wnt expression can lead to the evolution of bold phenotypes, and show that pterin pigments provide the primary source of coloration in U. ornatrix patterns. The final chapter focuses on the evolution of …
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Reconfigurability in space systems : architecting framework and case studies
… Systems since it allows for resource efficiency, evolvability, and enhanced survivability. Although it is often regarded as a desirable quality for a system, it has traditionally been difficult to quantitatively analyze its effects on various system properties in the early design stage. In order …
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FUNCTIONAL STATISTICAL LEARNING METHODS APPLIED TO HUMAN EMOTION RECOGNITION FROM FACIAL VIDEOS
… on the dynamic properties of continuity and evolvability inherent in functional data extracted from facial videos, which possess distinct properties compared to the static facial images predominantly used in traditional research methods. Our approach employs multivariate function-on-scalar …
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Modeling Complex Adaptive Systems and Complexity for Interactive Art
… ability, maximum fitness and maximum evolvability.<br/><br/>Several scientific models have simulated Complex Adaptive Systems. These try to model the emergence of complexity within computer-simulated environments inhabited by artificially evolving organisms. My objective in this thesis …
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Value centric approach to target system modularization using multi-attribute tradespace exploration and network measures of component modularity
… of a system can impact the systems flexibility, evolvability, scalability, mass, costs, and development schedule. Making these modularization decisions is a key job of the system architect. There exists a need to provide the system architect tools that will help focus modularization efforts on …
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Tailorability-focused recommendations for United States Air Force software acquisition policy
… solution, so that the required quality and evolvability of military systems are not compromised in execution of the national security mission.
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