Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 48 for “"evolutionary trajectory"”.
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Variation in influenza virus neuraminidase activity influences the evolutionary trajectory of hemagglutinin
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2026-05-01
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From Relatedness to Complexity in Regional Industrial Evolution
… structure, complexity may be a stage in its evolutionary trajectory. ‘Regional’ emphasises the geographical context for economic activities, while ‘industrial’ is defined as a meso level compared with a micro firm level or a macro aggregate level. ‘Complexity’ provides a quality measure of …
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Signatures and forgeries: optimality in a coevolutionary arms race
… antagonistically, ‘arms races’ played out on coevolutionary battlegrounds can drive the rapid evolution of intricate and complex adaptations in each species. However, evolution in one species may prevent optimality in these adaptations from being realised in the other. In the Choma District of …
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Tokenized Finance and Monetary Law: The Evolving Role of the Central Bank in the Age of Digital Currency
… the role played by the law in guiding the evolutionary trajectory of the central bank and monetary affairs generally. Our investigation revealed that money and the law evolved alongside economic development and the inherent complexities in trade and exchange.
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The phylogenesis of palaeoarts, and their coevolution in relation to artification
… its relevance for developing an account of the evolutionary trajectory of art-making in humans and hominins. The debate about the evolution of art-making has produced many theories of how arts evolved in humans’ deep past. One of the most promising views is the hypothesis of artification, that …
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Bridging the gap between microbial and metazoan evolutionary history
… to underpin most modern ecosystems, its evolutionary trajectory remains murky. This is predominantly due to the dearth of diagnostic microbial fossils and biomarkers. Conversely, metazoans (animals) emerged relatively recently and have deposited a thorough archive of their existence in …
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Molecular basis of the evolution of new protein functions: Kemp elimination and phosphoryl transfer reactions
… of single amino acid mutations, typical of an evolutionary trajectory, can result in dramatic changes in catalytic activity, specificity and protein solubility. Various strategies were employed to achieve this aim, including analysis of existing literature concerning the various models and …
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Molecular basis of the evolution of new protein functions: Kemp elimination and phosphoryl transfer reactions
… of single amino acid mutations, typical of an evolutionary trajectory, can result in dramatic changes in catalytic activity, specificity and protein solubility. Various strategies were employed to achieve this aim, including analysis of existing literature concerning the various models and …
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Ontogeny of the temporomandibular joint and middle ear of the Virginia opossum (Didelphis virginiana) and their implications for mammalian cranial evolution
… jaw joint is a remarkable example of vertebrate evolutionary history. We have a deep understanding of how the bones of the ear and jaw have evolved from the fossil record, however the knowledge surrounding the evolutionary origins of soft tissues of the temporomandibular joint (TMJ), such as the …
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A biogeochemical investigation of Trunk River Lagoon, Falmouth, Massachusetts
… anthropogenic influences, shedding light on the evolutionary trajectory of this aquatic ecosystem. From ancient sediment records to contemporary microbial communities, each aspect offers unique insights into environmental changes and the implications for interpreting biomarker signals In chapter …
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Branching out: A comparative analysis of demographic determinants of mammalian speciation
… mammals, and how these relationships shape macroevolutionary patterns of speciation and species richness. The thesis is divided into two sections that approach the question from different angles. The first is focused on extant mammals and uses subspecies as a proxy for population isolates to ask …
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The Contribution of Microfinance Institutions to Entrepreneurship Development in the Vhembe District, Limpopo Province, South Africa
… microfinance’s conceptual foundations and evolutionary trajectory within South African contexts, with particular emphasis on financial inclusion and entrepreneurship development. Evidence reveals multidimensional benefits extending beyond capital access to encompass entrepreneurial …
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Decoding Copy Number Substructure and Evolution From Single Cell Genomics
… single cell technologies. Therefore, the evolutionary trajectory after the punctuated burst remains unknown. To address this question, we sequenced 9,765 cells from 8 primary TNBCs and 6,413 cells from 4 TNBC cell lines using a novel single cell DNA sequencing method, Acoustic Cell …
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Simulating recombinant sequence date to evaluate and improve computational methods of multiple sequence alignment and recombinant identification
Motivation. Recombination is a central evolutionary process that substantially changes the structure of genomes and shapes their evolutionary trajectory. Recombination detection is thus an important computational step in understanding the evolutionary history of nucleotide sequences, and the …
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Genomic Evolution of Chemoresistance In Triple-Negative Breast Cancer Delineated By Single Cell Sequencing
… and acquired resistance shed light on the evolutionary trajectory of chemoresistance in TNBC patients.</p>
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Evolutionary dynamics of digitized organizational routines
… the effects of increased digitization on the evolutionary dynamics of organizational routines. Do routines become more flexible, or more rigid, as the mix of digital technologies and human actors changes? What are the mechanisms that govern the evolution of routines? The dissertation theorizes …
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Bacterial collectives
… paradigmatic Lewontin-sense. In the framework of evolutionary transitions in individuality, such collectives must first emerge and then acquire Darwinian individuality, gaining variation, reproduction, and heredity at the collective level. Populations of Pseudomonas fluorescens SBW25 provide a …
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Higher-order interaction inhibits bacterial invasion of a phototroph-predator microbial community
… we explore how the environment determines evolutionary trajectory when there exists a trade-off between beneficial traits. We select Escherichia coli for faster migration through a porous environment, a process which depends on both motility and growth. Evolving faster migration in rich …
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Evolvability of a viral protease: experimental evolution of catalysis, robustness and specificity
… mutations are abundant at each step along the evolutionary trajectory, enriched around the active site periphery. It is currently unclear how seemingly neutral mutations affect further adaptive evolution. I used high-throughput directed evolution to accumulate neutral variation in large, …
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Towards a Temporal Theory of Ecology: Body Mass Role for Activity Patterns of North American Artiodactyls
… can shape ecological patterns and impact the evolutionary trajectory of a species. The metabolic theory of ecology links body mass to multiple ecological traits. This study seeks to extend these insights to activity patterns at a macroecological scale, using the large repository of camera trap …
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