Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"evolutionary constraints"”.
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Evolutionary Constraints Specifying Protein Folding and Function
… provided a sufficiently detailed description of evolutionary design constraints to allow the design of novel WW domain sequences that fold and function like natural proteins. This work expands the initial investigations, and probes the minimal information content necessary to specify the WW …
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Modeling Evolutionary Constraints and Improving Multiple Sequence Alignments using Residue Couplings
Residue coupling in protein families has received much attention as an important indicator toward predicting protein structures and revealing functional insight into proteins. Existing coupling methods identify largely pairwise couplings and express couplings over amino acid combinations, which do …
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Evolution of protein structure, function, and dynamics in biological systems
… to achieve common goals. We find that evolutionary constraints vary with different levels of granularity of the structure of biological systems. Different levels of organization and their parts often use similar strategies to achieve different goals. For example, at the organismal level …
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Constraints on the adaptive potential of ectotherms to climate change
… rely heavily on temperature. While rapid evolutionary adaptation has been proposed as a potential pathway to survival, the adaptive potential of ectotherms may be inherently limited by evolutionary constraints. In this dissertation, I combine theoretical and empirical approaches to …
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The legacy of macroevolution: understanding and predicting evolutionary responses to novel environments
… Two factors that play an important role are evolutionary constraints and contingencies. Evolutionary constraints are limitations on how species can adapt and change imposed by past evolutionary history, which could be driven by genetic, developmental, or functional variation. Evolutionary …
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The Debunking Project. Developing a Framework for the Scope and Requirements of Successful Evolutionary Debunking Arguments
… the theoretical and empirical foundations of Evolutionary Debunking Arguments (EDAs), a critical philosophical type of argument used to challenge realist positions across various domains, notably morality. The dissertation systematically analyzes how EDAs function, what they require as minimal …
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A macro- and micro-evolutionary investigation of African Camponotus ants
… mitochondrial genes are evolving under different evolutionary constraints. Specifically, the cytochrome oxidase II gene displays greater rate heterogeneity than the cytochrome b gene, thereby decreasing its utility for phylogenetic analyses. Combining sequence data from both genes resulted in more …
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Computational Prediction of Functional Elements through Comparative Genomics
… the sequences from multiple species at varying evolutionary distances, has now merged as a very powerful approach for identifying variety types of functional elements, such as protein coding genes, transcriptional regulatory sequences, and non-coding RNA genes. This dissertation research has …
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Architecture and Evolution of Xylem-related Gene Coexpression Networks in Poplars
… understanding of the biological function and evolutionary constraints on the relevant genes, which can be gained through the use of modern computational approaches. Numerous approaches have being developed to advance these goals, and interaction network mapping is one of them. This method has …
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RNA sequencing for the study of gene expression regulation
… that isoform usage may be under different evolutionary constraints. These observations have important implications for understanding mammalian gene expression divergence and for understanding how speciation occurs.
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Dimensionality reduction in immunology : from viruses to cells
… HIV requires a combined understanding of the evolutionary constraints of the virus, as well as of the immunologic determinants associated with effective viremic control. Recent technologies enable viral and immune parameters to be measured at an unprecedented scale and resolution across …
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Protein structure determination using evolutionary information
… stability, and function. The record of the evolutionary process, which in itself is probabilistic, is contained within a multiple sequence alignment. A statistical model that accurately describes these evolutionary constraints for a given gene or a set of genes, should allow for the …
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Evolutionary, structural and functional features of cellular signalling networks
… a structural feature which may influence local evolutionary rates. Several examples of complex PTM signalling systems are then described. Chapter 2 presents a study of the evolution of modified amino acids in human proteins. By analysing sequence, polymorphism and mutation data at the species, …
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Examining neotropical primate community structure at regional and local scales : insights from taxonomic and phylogenetic approaches
… However, these differences may reflect evolutionary constraints of species, rather than active selection. I investigated niche overlap and presence of niche conservatism for primate species at three communities. For the niche characteristics measured by my study, I found no significant …
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Formation of Low-Mass X-Ray Binaries
… by mass-transfer stability and system-age constraints only. It is further shown that super-Eddington mass transfer accompanied by mass loss is crucial for the formation of LMXBs with evolved donors; also systems with ultra-short periods must have survived such a super-critical phase. LMXBs …
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Identification and Analysis of A Novel Role For The to usled-Like Kinase In Regulating Mitotic Spindle Dynamics
… example of how cells become cancerous by evading evolutionary constraints. The Tousled kinase (Tsl) was initially identified in <em>Arabidopsis thaliana </em>as a developmentally important kinase. There are two mammalian orthologues of Tsl and one orthologue in <em>C. elegans</em>, TLK-1, which is …
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Reimagining the Inner Ear: A Morphometric Modeling Approach for Establishing Shape Change in the Evolution of the Human Otolith System
… fossil hominins to elucidate the comparative and evolutionary aspects of the human otolith system. The morphometric model is generated using new visualization modalities combining spherical harmonic-based and landmark-based shape analyses. The model establishes the relationship between the …
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Skeletal evolution and convergence in the hyperdiverse passerine radiation
… 3 & 4) to shed light on aspects of passerine evolutionary history and diversification. Chapter 2 comprises a novel, comprehensive anatomical dataset of the passerine carpometacarpus, an anatomically variable bone in the wing. Using these data, I attempt to elucidate the phylogenetic affinities …
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Chromosome evolution in Lepidoptera
… only recently been able to reconstruct the exact evolutionary histories of chromosome rearrangements thanks to the availability of chromosome-level genomes. Consequently, the evolutionary forces and mechanisms that shape the varying rates of chromosome rearrangement across eukaryotes remain …
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Binary Star Systems with Asymmetrically Heated Disks: Thermal Phase Curves for the Disk in Epsilon Aurigae
… of the disk---and occurs every 27.1-years. Its evolutionary status is still debated, along with the true nature of each stellar component, due to the high uncertainty in its parallax. The disk is similarly debated from the near absence of solid state infrared spectral features indicating its …
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