Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 53 for “"etoposide"”.
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Enhanced Etoposide Solubility and Anticancer Activity using Complexation and Nanotechnology
Etoposide is a first line treatment for different cancer types that can be used either alone or in combination with other therapeutic agents. However, systemic toxicity, variable oral bioavailability, and high drug resistance are the three main drawbacks which hamper etoposide activity. The central …
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Effect of TIS21 on DNA Damage Repair Induced by Etoposide
… to wild type MEFs. Foci formation of H2AX after etoposide treatment in LacZ infected Huh7 cells were more retained than TIS21 infected Huh7 cells. Comet assay also showed that DNA damage induced by etoposide were smaller in TIS21 expressed cells. In order to examine TIS21 involved in DNA damage …
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Anti-Gd2 Etoposide-Loaded Immunoliposomes For The Treatment of Gd2 Positive Tumors
… system. In this study, we have encapsulated etoposide, a topoisomerase inhibitor effective against a wide range of cancers, in surface modified liposomes decorated with anti-GD2 antibodies. We characterized the properties of the liposomes using a variety of methods including dynamic light …
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Estudo de fase I e farmacocinética com etoposide oral em crianças e adolescentes com tumores sólidos refratários
… tumores refratários ou recaídos. Estudos com Etoposide revelaram uma clara relação entre o tempo de exposição e os seus efeitos citotóxicos, mostrando resultados superiores com o uso de doses fracionadas quando comparado ao uso de uma dose única. Estudos de farmacocinética sugerem que as …
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Estudo histórico para avaliar o uso da associação da ifosfamida, carboplatina e etoposide (ICE) para tratamento de neoplasias refratárias em pacientes pediátricos e adolescentes
… com câncer, assim como a Ifosfamida (I) e o Etoposide (E). A combinação destas 3 drogas, em um regime que passaremos a designar como ICE, tem potencial de aumentar os índices de resposta, embora aumente também os riscos de toxicidade. O objetivo principal deste estudo foi avaliar a resposta e …
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Characterization of Fasting-Induced p21 Expression and Protection of Intestinal Stem Cells
… mice from what would normally be lethal doses of etoposide. I hypothesized that p21 may be involved in this protection, as <italic>p21</italic> expression increased in response to both fasting and DNA damage. I demonstrated that fasting prior to a high dose of etoposide treatment enhanced survival …
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Histone Lysine Demethylase KDM4A as a Therapeutic Target for Small Cell Lung Cancer
… patients are initially responsive to first-line etoposide and platin chemotherapy, they soon develop resistance, and no effective second-line therapy is currently available. A recent large NCI screen showed that over 60 SCLC cell line models responded to > 500 investigational drugs in a manner …
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The Chemical-Induced Genotoxicity of Depleted Uranium
… to 0.13 μM UA in the presence of 0 – 25 μM of etoposide for 0 – 48 hr. Results indicate that UA inhibited double strand break repair. Coexposures of etoposide and UA synergistically induced cytotoxicity compared to individual treatments and untreated cells. Co-exposed UA and etoposide treated …
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Regulation of cytotoxic drug-induced apoptosis by death receptor 5 in human colon cancer cells
… similar to 5-FU, when cells are treated with etoposide,another cytotoxic drug, JNK is also activated and initiated by DR5 and mediated by FADD and caspase-8. Thus, in the present study, the factors that are involved in activating JNK after 5-FU and etoposide treatment have been identified. The …
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The use of novel poly(allylamine) based amphiphilic polymers for drug delivery.
… drugs, propofol, prednisolone griseofulvin, etoposide and novel anticancer agent BNIPDaoct. The Ch5 and Dansyl10 showed excellent drug solubilisation capacities. At 6 mgmL-1 the Ch5 achieved propofol solubility 70-fold greater than its aqueous solubility, prednisolone, griseofulvin and …
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Stabilization of Topoisomerase 2 Mutants Initiates the Formation of Duplications in DNA
… stabilization by chemotherapeutic drugs such as etoposide leads to persistent and potentially toxic DSBs. This thesis characterizes two novel top2 mutants, both of which are associated with a mutation signature characterized by de novo duplications. These duplication events are dependent on clean …
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The multifactorial nature of hypoxia-induced drug resistance in cancer: involvement of hypoxia-inducible factor 1
… hypoxia-induced resistance to doxorubicin and etoposide in human tumor cells. In addition, novel findings revealed that hypoxia-induced drug resistance occurred independently of changes in the apoptotic fraction and was associated with decreased drug-induced senescence. DNA damage measured at …
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The AMPK signalling pathway in cancer and DNA damage
… as ionising radiation and the anti-cancer drug etoposide. However, the molecular mechanism underlying this activation was unclear. This thesis shows that etoposide activates AMPK in a CaMKKβ-dependent manner in HeLa cells and G361 cells, both of which lack LKB1. Activation is restricted to the …
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Analysis of drug resistance and the role of the stem cell niche in leukaemia
Glucocorticoids and etoposide are used to treat acute lymphoblastic leukaemia (ALL) as they induce death in lymphoblasts through the glucocorticoid receptor (GR) and p53. However, glucocorticoid resistance, cell death mechanisms and the contribution of the bone marrow microenvironment to drug …
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The cell-intrinsic innate immune response to DNA damage in human cells
… fibroblasts, and monocytes, and found that Etoposide, an inducer of double strand breaks, induced an early innate immune response, characterised by Type-I interferon and inflammatory cytokine production. This innate immune response to DNA damage was particularly potent in keratinocytes. This …
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Identifying a role for Ciz1 in the DNA damage response
… adapted to permit study of events resulting from etoposide-induced DNA damage. The system was characterised, and its potential as a screening tool to assess inhibitors of the DDR demonstrated, before being used to confirm PIKK-dependent phosphorylation of SQ/TQ motifs in both full length Ciz1 and …
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COMPARATIVE PROTEOMICS STUDIES OF SOLUBLE NUCLEAR PROTEINS OF DRUG SUSCEPTIBLE AND RESISTANT HUMAN BREAST CANCER MCF-7 CELLS
… in MCF-7 breast cancer cell lines resistant to etoposide, mitoxantrone, adriamycin in the presence of verapamil by both gel comparisons and isotope labeling. Abundances of cytoskeleton proteins, such as cytokeratin 8, cytokeratin 19, septin 2, and alpha tropomyosin, are altered in common across …
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Monitoring apoptosis in intact cells by high-resolution magic angle spinning 1H NMR spectroscopy
… profiles of cells treated with cisplatin and etoposide after 3, 8, 24 and 48 h. The results are compared to the analysis of organic cell extracts by solution-state 1H NMR spectroscopy to demonstrate lipid compartmentalisation and highlight the advantages of HRMAS 1H NMR spectroscopy in …
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NEW INSIGHTS INTO THE REGULATION OF MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION DURING APOPTOSIS
… were examined after prolonged treatment with etoposide ( 6 h). Total cellular cytochrome c and Smac were decreased after 24 h of incubation. Interestingly, inhibition of the 26S proteasome by co-treatment of Apaf-1-deficient cells with bortezomib or MG132 led to the robust retention of total …
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