Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"ethionamide"”.
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Fragment-based approaches to targeting EthR from mycobacterium tuberculosis
… are urgently needed to fight this disease. Ethionamide, a second-line drug is administered as a prodrug which is activated in vivo by the enzyme EthA, which is in turn regulated by EthR. The disruption of the action of EthR could lead to novel therapeutics which could enhance the efficacy of …
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A pharmacometric approach to optimal use of second line drugs for multidrug-resistant tuberculosis
… formulations of pyrazinamide, moxifloxacin, ethionamide, ethambutol, cycloserine, and isoniazid. Results and conclusions We found no measurable terizidone in plasma supporting the hypothesis that terizidone is hydrolysed pre-systemically to cycloserine. The cycloserine time-concentration …
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Investigating the effect of a Mycobacterium tuberculosis inhA promoter mutation in cell envelope composition and morphology
… IPMs contribute resistance to INH and ethionamide which are first and second-line drugs respectively that target mycolic acid (MA) synthesis. MA are characteristic components of mycobacterial species’ cell wall and contribute to the impermeability of cell wall by virtue of its …