Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"ethanol and nicotine"”.
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Assessment of Ethanol and Nicotine Interactions in the Rat Model: Pharmacotherapeutics, Adolescence, and the Mesolimbic System
Alcohol use disorder (AUD) and nicotine dependence often result in serious health problems and are top contributors to preventable deaths worldwide. Co-addiction to alcohol and nicotine is the most common form of polysubstance abuse. Epidemiological studies indicate that more than 80% of …
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The Effects of Ethanol and Nicotine on Hepatic and Brain CYP2 Family Enzymes in African Green Monkeys
… vast array of xenobiotics, including many drugs and toxins. Induction or downregulation of the CYPs can have important consequences such as changes in drug efficacy and altered susceptibility to toxicity. Our study investigated the independent and combined effects of ethanol and nicotine on …
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Studies of nicotinic acetylcholine receptors containing α4 and α6 subunits in nicotine-induced synaptic plasticity in brain reward areas
… threat to public health in the United States and abroad, and development of new therapeutic approaches is a major priority. Nicotine, the primary psychoactive compound in tobacco smoke, activates and/or desensitizes nicotinic acetylcholine receptors (nAChRs) throughout the brain. nAChRs in …
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Preclinical Investigations Of Genetic Correlates Of Alcohol Use Disorder
… alcohol use that has serious medical and social consequences. AUD is heritable and intense work has been done to characterize its genetic basis. Preclinical studies have been critical in describing the functional significance of genes associated with AUD and have advanced our …
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The interaction of psychomotor stimulants and sedative hypnotics in the conditioned taste aversion paradigm
Specific pairs of drugs such as cocaine and ethanol and nicotine and ethanol are widely used by humans. A variety of existing studies have reported behavioral and pharmacological interactive effects between these pairs of drugs. The present thesis was designed to further examine the potential …