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Showing 1 to 20 of 69 for “"estrone"”.
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Studies in ring D fragmentation of estrone
… in an overall yield of 60% from estrone 3-methyl ether. The fragmentation approaches involved conjugate stannylation and silylation of 3-methoxyestra-1,3,5,(10), 15-tetraen-17 -one to give the 15β-trimethylstannyl and 15β-trimethylsilyl 17 -ketones respectively. The stannyl ketone …
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In vitro characterization of aromatase, estrone sulfotransferase and estrone sulfatase activities in the porcine placenta and endometrium at 30, 60 and 90 days of gestation
… the activities of three enzymes, aromatase, estrone (E1) sulfotransferase and E] sulfatase, in the porcine placenta and endometrium on d 30, 60 and 90 of gestation. These enzymes play key roles in determining in utero concentrations of estrogens. Days 30, 60 and 90 were chosen because …
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Polymeric Adsorption of Estrone from Water and Photocatalytic Degradation by Zinc Oxide
… contaminant in treated wastewater effluents, estrone was selected as the target contaminant in this study. A three-stage process was designed to eliminate the risk of this contaminant: 1) capture of trace levels of estrone from water via a reversible chemisorption process; 2) desorption of …
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Fate of 17α-Estradiol, 17β-Estradiol, and Estrone in Agricultural Soils and Sediments
… (17α-E2), 17β-estradiol (17β-E2), and estrone (E1). While these estrogens are critical to endocrine systems, the low concentrations observed in the environment can disrupt endocrine function in non-target organisms, e.g., altering secondary sex characteristics which can lead to changes …
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Design, Synthesis, and Biological Screening of Novel Cucurbitacin/ Estrone Analogs Towards Treatment of Melanoma
<p>Cucurbitacins are highly oxygenated tetracyclic triterpene natural products. They are known for their broad spectrum biological activities. Cucurbitacins showed potential activity towards different cancer cell lines with lack of investigation of their activity towards treatment of melanoma. …
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Design, Synthesis and Biological Screening of Novel Cucsinspired Estrone Analogues Towards Treatment of Hepatocellular Carcinoma
… challenges of total synthesis of CUCS, therefore estrone skeleton were used as a starting scaffold to synthesize CUCS-inspire estrone analogues (CIEA) targeting HCC. Molecular docking study of cucurbitacin-inspired estrone analogs was conducted using 1M17 (EGFR receptor) co-crystallized with …
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The effect of age, and thyroid status on the response of ovariectomized rats to estrone
Thesis (M.S.)--Michigan State College of Agriculture and Applied Science. Dept. of Physiology and Pharmacology, 1948
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The Effect of Varying Levels of Estrone and Progesterone on The Length Ofgestation in The Rat
Made available in DSpace on 2014-12-12T00:36:22Z (GMT). No. of bitstreams: 1 7114729.pdf: 3614279 bytes, checksum: 44664594b6b3e45c47092515f03dd977 (MD5) Previous issue date: 1970
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A novel, versatile D-BCD steroid construction strategy, illustrated by the total syntheses of estrone and desogestrel
… total syntheses of the steroids desogestrel and estrone, utilizing a 1,4 addition/alkylation process to install the correct stereochemistry at C8, C13 and C14 in a single-pot operation. The racemic total synthesis of desogestrel includes a successful domino anionic cyclisation leading to the …
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In vitro progesterone and estrone synthesis by the porcine placenta and endometrium at 30, 60 and 90 days of gestation
… of progesterone (P₄), testosterone (T) and estrone (E₁) at 30, 60 and 90 days of gestation. Duplicate 300 mg samples of placenta, endometrium or both (co-incubation) were incubated in medium199 containing either no P₅, P₅, P₅ + hCG or P₅ + cAMP for either zero (control), .5, 1 or 2 h. The …
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Studies on the Luteal Function in the Late Pregnant Cow
… of gestation received intravenous infusion of estrone or vehicle during 5 days. CL were removed at 120 hours after the beginning of the infusion for in vitro incubations with LH and cAMP. Estrone infusion caused an increase in the concentrations of unconjugated estrone, and unconjugated and …
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Intrauterine position in pigs: effects on conceptus development and fetal fluids steroid content
… dehydroepiandrosterone sulfate, testosterone, estrone and estrone sulfate) were evaluated. Four fetal positions were studied: females between females (f2F), females between males (fOF) , males between females (m2F) and males between males (mOF). Fetuses examined from ovariectomized (OVX) …
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Development of a sample enrichment probe method for the gas chromatography-mass spectrometry analysis of hormones in water
… determination of endogenous steroid hormones (estrone, I 7P-estradiol and testosterone) in water using gas chromatography-mass spectrometry (GC-MS). SEPs constructed of thin stainless steel rods of inert material or sections of a polyimide coated megabore GC column provided at one end with a …
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Binding of Steroid Hormones In Vitro by Water-Insoluble Dietary Fiber
… further, we assessed the in vitro binding of estrone, estradiol-17β, and testosterone to a water-insoluble fiber fraction obtained from composite food samples of 18 Seventh-day Adventist (SDA) nonvegetarian (NV), 20 SDA lacto-ovovegetarian (LOV), and 15 SDA vegan (V) men. Three-day dietary …
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The application of tracer techniques in endocrinology
Using a labelled estrogen (radiodibromestrone) it has been demonstrated that none of the body tissues accumulate the steroid to any marked degree. The excretion route was found to be by way of the bile into the intestine . An enterohepatic circulation has been suggested, since some estrone was …
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ΣΥΝΘΕΣΗ ΤΡΟΠΟΠΟΙΗΜΕΝΩΝ ΣΤΕΡΟΕΙΔΩΝ ΕΣΤΕΡΩΝ, ΜΕ ΠΑΡΑΓΩΓΑ ΤΗΣ Ν, Ν-ΔΙΣ(2-ΧΛΩΡΟΑΙΘΥΛ)ΑΝΙΛΙΝΗΣ ΚΑΙ ΒΙΟΛΟΓΙΚΗ ΔΡΑΣΗ ΑΥΤΩΝ
… DEHYDRO-EPI-ANDROSTERONE, TESTOSTERONE, ESTRONE, PREGNENOLONE AND ANDROSTANALONE.
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The relationship of arylsulfatase C and the steroid sulfatases in mammals
… many properties with the steroid sulfatases: estrone-sulfate sulfatase (E1S-sulfatase) and dehydroepiandrosterone-sulfate sulfatase (DHEAS-sulfatase). They have similar subcellular localization, are membrane bound, have alkaline pH optima, are resistant to inhibition by sulfate and phosphate, …
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Determination of Biodegradation Kinetics of Select Pharmaceuticals and Personal Care Products in an Activated Sludge System through Respirometry
… (PPCPs) triclosan, caffeine, acetaminophen, estrone (E1), 17β estradiol (E2), and 17α ethinyl-estradiol (EE2). The activated sludge biomass used for respirometry testing was obtained from a local wastewater treatment plant (WWTP). The plant treats municipal wastewater, and the activated …
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