Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"estrogenic effects"”.
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Estrogenic Effects of Genistein in Ovariectomized Gilts
Genistein, has a range of estrogenic actions, however only limited research has been done to investigate its effects in swine. The objective was to characterize the effects of administration of a graded dose of genistein on tissues known to be estrogen sensitive. Thirty-four post-pubertal gilts …
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Zebrafish as a Model for Studying Estrogen Signaling and Estrogenic Endocrine Disruption
… range of chemicals, which are classified as estrogenic endocrine disruptors (EEDs), can bind to ERs or GPERs, thereby interfering with estrogen signaling and causing adverse effects. Zebrafish embryos/larvae are an emerging model used in xenoestrogen studies. However, endogenous estrogen …
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Selektive Östrogen-Rezeptor-Modulatoren (SERM) und ihre Wirkung auf die Proliferation und Differenzierung des Rattenendometriums
… estrogenagonistic and estrogenantagonistic effects. Both SERMs tamoxifen and raloxifene are strong antiestrogens in-vivo. In-vitro they show different estrogenic effects. The endometrium is an important target of estrogenic effects. Depending on the estrogenic potential of the pharmaceutical …
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The anti-estrogenic and liver metabolic effects of DHAA in rainbow trout (oncorhynchus mykiss)
… present in pulp and paper mills, may have anti-estrogenic effects in fish. A chronic-exposure toxicity experiment using immature rainbow trout (Oncorhynchus mykiss) was conducted in order to assess the endocrine disrupting and liver metabolic effects of the wood extractives DHAA and β- …
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The reproductive health effects of along term DDT exposure on malaria vector control workers in Northern Province, South Africa
… exposure-related anti-androgenic and/or estrogenic effects reflected in abnormalities in hormone levels, semen, sexual function and fertility. A cross-sectional study of 60 workers from 3 camps situated near Malaria Control Center (MMC) in Tzaneen was performed.
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The Role of Membrane-Bound Receptors in the Rapid Estrogenic Enhancements of Learning and Memory Within the Hippocampus
… the dorsal hippocampus as one site of these estrogenic enhancing effects. Whether these rapid estrogenic effects are mediated solely by membrane-bound estrogen receptors is currently unknown. This study sought to determine the role of membrane estrogen receptors in the rapid effects of 17-β …
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I. A Structure-Based Approach Toward the Development of a Ligand-Receptor System With Unique Specificity. II. Synthesis and Evaluation of Hexahydrochrysene and Tetrahydrobenzofluorene Derivatives as Selective Estrogen Receptor Modulators
… ligands, trying to mimick or antagonize estrogenic effects. Partial agonists, with a tissue selective agonist/antagonist profile, termed selective estrogen receptor modulators (SERMs), are better candidates for applications in the treatment of estrogen sensitive breast cancer and …
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Effects of ibuprofen on Rainbow Trout (Oncorhynchus mykiss) following acute and chronic waterborne exposures
… was to determine the acute and chronic effects of ibuprofen on rainbow trout (Oncorhynchus mykiss). Cyclooxygenase (COX) activity, vitellogenin (VTG) concentration and ethoxyresorufin-O-deethylase (EROD) activity were evaluated following waterborne ibuprofen exposure of trout to 1 and 10 …
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The Phytoestrogen Genistein Induces Thymic and Immune Changes: A Human Health Concern
… formulas has aroused concern due to potential estrogenic effects of the soy isoflavones genistein and daidzein. Here we show that subcutaneous genistein injections in ovariectomized adult mice produced dose-responsive decreases in thymic weight of up to 80%. Genistein's thymic effects occurred …
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The Role of Microglia in the Effects of Steroid Hormones on Brain Inflammation
… to the neuroprotective and anti-inflammatory effects of steroid hormones. However, our comprehension of the cellular targets and mechanisms of action of these hormones in the CNS is still unresolved. In view of these limitations, the main question addressed in this dissertation was the role …
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Cross-modulatory Actions of Cell Cycle Machinery on Estrogen Receptor-alpha Level and Transcriptional Activity in Breast Cancer Cells
… bound ERα, and hence the growth stimulatory effects of estradiol, has been widely used for decades for treating patients with ERα positive or hormone dependent breast cancer. Despite its obvious benefits, in as high as 40% of the patients receiving tamoxifen therapy there is an eventual …
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Untersuchung endokriner Effekte von Benzophenon-2 und 17β-Estradiol in estrogen-rezeptiven Organen
Viele essentielle Funktionen des menschlichen Körpers werden durch Hormone gesteuert. Diese Botenstoffe sind unter anderem an der Regulation des Wachstums, der Reproduktion, des Stoffwechsels, des Elektrolyt- und Wasserhaushaltes und der Immunabwehr beteiligt. Es ist bekannt, dass exogene …