Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"estrogen signaling"”.
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Estrogen signaling during decidualization
… the developing embryo. Steroid hormones estrogen (E) and progesterone (P) acting through their cognate nuclear receptors critically modulate this maternal-fetal interaction that entails the initial success of procreation. While E is primarily involved in cell proliferation and acquisition …
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Estrogen Signaling in Trigeminal Nociception
… models of chronic pain, and is also activated by estrogen in sensory neurons. We used an established model of inflammatory trigeminal pain, injection of Complete Freund's adjuvant (CFA) into the masseter muscle, to determine whether ERK activation may play a role in hormone-related trigeminal pain …
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Estrogen signaling interacts with Sirt1 in adipocyte autophagy
… target for combating obesity. Both hormone signaling (e.g., ERα) and energy sensing factors (e.g., Sirt1) control metabolism and prevent adiposity, and in which they have been shown to play collaborate roles. However, how autophagy is involved in ERα and Sirt1's inhibitory roles on adiposity …
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Estrogen Signaling in the Ventromedial Hypothalamus Modulates Adipose Tissue Metabolic Adaptation
Brain estrogen receptor α (ERα) signaling plays a vital role in regulating energy homeostasis and adipose tissue metabolism. It has been demonstrated that ERα is abundantly expressed in the ventrolateral region of the ventromedial hypothalamus (vlVMH), a sex-dimorphic structure that directly …
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Zebrafish as a Model for Studying Estrogen Signaling and Estrogenic Endocrine Disruption
Estrogen signaling, mediated by estrogen receptors (ERs) and G-protein-coupled estrogen receptor (GPER), plays important roles in humans and wildlife. Perturbing estrogen signaling may lead to deleterious health problems such as infertility, developmental defects, metabolic disorders, and certain …
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The Influence of Estrogen Signaling on Male Reproduction in Medaka (Oryzias latipes)
… (EDCs) are ubiquitous and often act as xenoestrogens with the ability to disrupt estrogen signaling through differential binding to the various estrogen receptors. Exposure to these xenoestrogens has led to detrimental effects on male reproduction. In fish, observed effects include sex …
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THE EFFECT OF FLAXSEED AND ITS LIGNAN COMPONENT ON ESTROGEN SIGNALING AND METABOLISM IN NORMAL AND CANCEROUS HEN OVARIES
… in the United States. It has been reported that estrogen (E2) can promote metastasis of ovarian tumor cells through its nuclear receptor (ER). E2 is a potent mitogen and can stimulate the growth and invasion of ovarian cancer cells. We have previously shown that flaxseed diet decreases the …
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Repressor of Estrogen Receptor Activity (REA) is a gene dose-dependent coregulator protein affecting estrogen signaling and cell survival
Repressor of Estrogen Receptor Activity (REA) is an evolutionarily conserved protein with established roles in multiple, essential cellular processes including transcription, mitochondrial biogenesis and replicative senescence. Previous reports suggest that REA is a multifunctional protein with …
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An integrated network of estrogen receptors alpha and beta, and coregulators, for deciphering estrogen signaling in breast cancer cells
… binds to sites substantially less enriched in estrogen response element (ERE) sequence motifs. Gene chip microarray transcriptional profiling and gene ontology analysis delineated a core set of genes that correlate with ERα proliferative and ERβ anti-proliferative effects in breast cancer …
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Assessment of the impact of early life trauma, changes in estrogen signaling, and neurotoxic molecules in a mouse model of multiple sclerosis
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2023-12-01
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The Molecular Components of Estrogen Receptor Beta (ERβ) Signaling in Neuronal Sytems
… living upwards of 50 years without circulating estrogens, therefore, it is essential to investigate how the brain is changed by estrogen deprivation and also how aging influences these changes. The Women's Health Initiative (WHI) study spurred rigorous debate regarding estrogen therapy for …
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Tamoxifen: Mechanisms of Resistance
<p>The role of estrogen in breast cancer has been recognized for decades. The selective estrogen receptor modulator tamoxifen was the first targeted therapy for the treatment of breast cancer. It was also the first drug approved by the FDA for the reduction of breast cancer risk. While tamoxifen …
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The Involvement of Estrogen Receptors in Astrocyte Survival
<p>Estrogens are a class of hormones that are demonstrated to be neuroprotective. The levels of estrogen in the body decline during menopause which can cause a variety of symptoms. Hormone replacement therapy (HRT) is a treatment option for menopause, however, it has been demonstrated to have …
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Altered responsiveness to estrogens at estrogen receptor subtype 1 modifies the expression of circadian rhythms and daily activity patterns in mice
… studies in women and in animals indicate that estrogen can modify the expression of daily rhythms; however, the exact mechanism and sites of action for steroid hormones have not been determined. Understanding the relationship of gonadal hormones on the normal functioning of circadian rhythms …
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Hormonal regulation of bone health: novel understandings of xenoestrogens and estrogen receptor-[alpha]
Estrogen is one of the most influential hormones on bone growth and maintenance throughout the life cycle in both men and women, but there are still unknown roles of estrogen and the estrogen receptors in males. In addition, exposure to xenoestrogens, or environmental compounds that have …
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Role of Cyclin-Dependent Kinase Inhibitors in Estrogen Regulation of Adipogenesis
… tissue is responsive to steroid hormones like estrogen. Loss of estrogen receptor a (ERalpha) caused a 100% increase in adipose tissue, indicating the importance of ERalpha signaling. ERalpha knockout mice (alphaERKO) mice have intact ERbeta signaling. Removal of ERbeta/estrogen signaling in …
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The Non-genomic Signaling Pathways Mediated By G-protein Coupled Estrogen Receptor 1 (GPER) In Coronary Arteries
… avenue of study is the novel G protein-coupled estrogen receptor (GPER) which mediates estrogen action. The major purpose of my studies in this dissertation is to investigate the role of GPER in porcine coronary artery tone regulation. In a series of studies, we tested four hypotheses: 1) …
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Regulation of the Glucocorticoid Receptor Promoter and Its Prognostic Value in Tamoxifen-Treated ER+ Breast Cancer
Most breast cancers are estrogen receptor positive (ER+) and therefore benefit from endocrine-based therapies such as tamoxifen which impair estrogen signaling. However, resistance is a major clinical concern and ER status alone is insufficient to predict treatment response. As a result, additional …
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The Kras/Mapk Pathway and Ligand Independent Activation of Erα: Implications For The Treatment of Endometrial Cancer
… of the PI3K/AKT and Ras/MAPK pathways activate estrogen receptor α (ERα) independent of estrogen, however, few studies have evaluated the role of the Ras/MAPK pathway in predicting response to hormonal therapy in EC. The aims of this project were to evaluate the role of ligand independent …
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Tamoxifen metabolites can target both aromatase and estrogen receptors
… two thirds of all diagnosed breast cancers are estrogen receptor (ER)-positive and are dependent on estrogen signaling. Drugs for the treatment of ER-positive breast cancer can be divided into three classes: selective estrogen receptor modulators (SERMs), selective estrogen receptor …
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