Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"estrogen receptor α"”.
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Role of estrogen receptor α and oxidative stress response proteins in the central nervous system
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The Molecular Mechanisms of Estrogen Receptor α on Two Single Nucleotide Polymorphisms to Regulate WNT Signaling in Osteoblasts
… to bone fracture. Genetic factors, estrogen deficiency, and dysregulation of the WNT signaling pathway contribute to the development of this disease. Genome-wide association studies have predicted that the single nucleotide polymorphisms (SNPs) rs2887571 and rs9921222 associate with …
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Estradiol regulation of leucine-rich repeat immunoglobulin-like domains protein 1 (LRIG 1) and roles of estrogen receptor in translational regulation in breast cancer cells
… of the expression of three proteins: the Estrogen Receptor α (ERα), the Progesterone Receptor (PR) and Heregulin 2 (HER2). The ER, though often considered responsible for driving tumor growth, is usually indicative of a good prognosis as ER-positive tumors are typically more indolent in …
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The Effects of Tamoxifen on Mammary Development in Prepubertal Heifers
… in prepubertal heifers given the anti-estrogen tamoxifen. Sixteen Holstein calves were randomly assigned to one of two treatment groups: tamoxifen-injected (TAM) or control (CON). Calves were subcutaneously injected daily from 28 to 120 days of age with 0.3 mg/kg tamoxifen or carrier. …
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Folate - Associations with breast cancer depending on intake, metabolism, genetic variation and estrogen receptor status.
… methylenetetrahydrofolate reductase (MTHFR) or estrogen receptor α and β expression of tumors. Food habit information and blood samples were collected 1991-96 from 17 035 women between 45 and 73 years in the MDC study. Until end of 2004, 544 cases of invasive breast cancer were diagnosed. High …
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Estrogen Signaling in the Ventromedial Hypothalamus Modulates Adipose Tissue Metabolic Adaptation
Brain estrogen receptor α (ERα) signaling plays a vital role in regulating energy homeostasis and adipose tissue metabolism. It has been demonstrated that ERα is abundantly expressed in the ventrolateral region of the ventromedial hypothalamus (vlVMH), a sex-dimorphic structure that directly …
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Understanding the relationship between large-scale chromatin structure and gene expression
… chromatin structure induced by the activation of estrogen responsive loci and determine what cellular processes are responsible for decompacting large-scale chromatin. Experiments were performed in hormonal responsive MCF-7 breast cancer cells where genes GREB1 and TFF1 are strongly upregulated …
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Intramammary infection in rapidly growing, non-lactating mammary glands
… the expression of integral mammogenic hormone receptors implicated in mammary growth. Non-pregnant non-lactating cows (n = 19) were administered estradiol and progesterone to stimulate mammary growth and 2 quarters of each cow were subsequently infused with either saline (n = 19) or …
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INVESTIGATING SEX DIFFERENCES IN THE TRANS-SYNAPTIC REGULATORS OF MESOLIMBIC DRIVEN PALATABLE FOOD INTAKE
… in situ hybridization analyses showed different estrogen receptor α distributions in the LSN and BNST in male and female that perhaps complement our palatable food intake studies of estrogen infusion into the LSN. In a cumulative analysis of these studies, we contend that mesolimbic driven …
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The Kras/Mapk Pathway and Ligand Independent Activation of Erα: Implications For The Treatment of Endometrial Cancer
… of the PI3K/AKT and Ras/MAPK pathways activate estrogen receptor α (ERα) independent of estrogen, however, few studies have evaluated the role of the Ras/MAPK pathway in predicting response to hormonal therapy in EC. The aims of this project were to evaluate the role of ligand independent …
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Systems Biology Study of Breast Cancer Endocrine Response and Resistance
… that breast cancer cells can switch between estrogen receptor α (ERα) regulated and growth factor receptor (GFR) regulated signaling pathways for survival and proliferation. A mathematical model based on the signaling crosstalk between ERα and GFR was constructed. The model successfully …
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Roles of CCN5 in regulating progression and therapeutic sensitivity of breast cancer
… the cancer cells do not express nuclear hormone receptors and human epidermal growth factor receptor 2 (HER2), have worse survival rate compared to the patients with luminal subtypes of cancer. Here, we have shown that Cysteine-rich 61-Connective Tissue Growth Factor-nephroblastoma-overexpressed …
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Context Dependent Roles of MDMX (MDM4) and MDM2 in Breast Cancer Proliferation and Circulating Tumor Cells
… MDMX. Expression of MDM2 and MDMX occurs in both estrogen receptor α positive (ER+) and triple negative breast cancer (TNBC). We and others have reported that estrogen activated MDM2 strongly promotes proliferation in ER+ T47D breast cancer cells in a p53-independent manner. Whether MDM2 elicits …
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Investigating upstream regulators of FOXA1 in breast cancer
… Due to its role in recruitment of nuclear receptors, such as estrogen receptor α (ERα) to enhancer regions, it is highly implicated in ERα positive breast cancer. Structural predictions of FOXA1 suggest a highly disordered structure with no clear pockets for rational drug design, making …
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Estrogen Regulation of the Pregnant Baboon Placental 11β-Hydroxysteroid Dehydrogenase (11β-HSD)-Catalyzed Metabolism of Cortisol and Cortisone and Its Effect on the Development of the Fetal Hypothalamic-Pituitary-Adrenal Axis
… and Albrecht previously demonstrated that the estrogen-regulated change in transuteroplacental metabolism of cortisol (F) and cortisone (E) from preferential reduction (E to F) at midgestation to oxidation (F to E) near term results in a decline of bioactive cortisol crossing the placenta and …
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A Novel Molecular Pathway Involving GPR10, REST, and PRICKLE1 in the Pathogenesis of Uterine Leiomyoma
… the molecular pathogenesis of UL. Environmental estrogen exposure is one of the most recognized risk factors associated with the development of UL tumors. At the cellular level, extensive evidence has linked the cell proliferation, survival and growth of UL tumors to the over-activation of the …
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Construction and Performance Optimization of Bioconjugated Nanosensors for Early Detection of Breast Cancer and Pro-inflammatory Diseases
… the detection of interleukin-6 (IL-6) and estrogen receptor α (ERα), among the key proteins for the initiation and progression of cardiovascular diseases and breast cancer, respectively. We explored and improved a passivation strategy for screening out non-target proteins in human serum, …
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Identifying new actions of estrogen receptor targetable with small molecules
Estrogens, acting via estrogen receptor α (ERα), stimulate the proliferation and metastatic potential of breast cancers, and likely some ovarian, endometrial, and cervical cancers. Endocrine therapy targeting these cancers often leads to development of resistance. Ovarian cancers do not respond to …
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The anticipatory unfolded protein response and estrogen receptor mutations in breast cancer
Estrogen, acting via estrogen receptor α (ERα), stimulates cancer cell proliferation and metastasis. Endocrine therapy targeting E2:ERα activity often leads to development of antiestrogen resistance. Approximately 30% of patients who have metastatic endocrine therapy resistant breast cancer express …
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Dietary Soy Protein Isoflavonoid Effects on the Reproductive Tract of the Nonhuman Primate and Neoplastic Human Prostate Gland
… concentrations, prostate tissue sex steroid receptor expression levels, androgen and estrogen receptor polymorphisms, and diet have all been proposed to explain these discrepancies in prostate cancer incidence in men living in Western countries when compared to men living in Asia. Lifestyle …
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