Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 822 for “"estrogen"”.
-
Estrogen Receptors: Interaction With Estrogen Response Elements and Estrogen Receptor-Associated Proteins
Since DNA-induced conformational changes in estrogen receptors affected recruitment of transcriptional coregulatory proteins, we examined differential recruitment of novel proteins. One novel protein was isolated and identified by protein sequencing as TAF-I beta, a protein previously implicated in …
-
Elucidation of the Molecular Mechanisms Underlying Estrogen-Mediated Estrogen Receptor Activation
… used to study the underlying mechanisms of estrogen-mediated transcriptional regulation. Previously shown, estradiol-mediated transcriptional regulation in the mouse uterus is biphasic and can be divided into initial (early) phase and subsequent (late) phase transcriptional events. In this …
-
Estrogen Receptors and Estrogen-Regulated Genes in the Male Reproductive Tract
Estrogen receptor-alpha (ERalpha) is essential for male fertility. The bisexual role and importance of estrogen in reproduction was established by the previous studies. However, there is considerable variation, both within and between species, in reports of nuclear steroid receptor localizations in …
-
Molecular mechanism of interactions between estrogen receptor and estrogen receptor selective genotoxins
… cells. Breast cancer cells often overexpress the estrogen receptor protein. By synthesizing a drug that not only binds and damages the DNA but also binds the abundant proteins in the cells, thereby blocking the damaged site from DNA repair proteins, a selective treatment of cancer cells can be …
-
Estrogen signaling during decidualization
… the developing embryo. Steroid hormones estrogen (E) and progesterone (P) acting through their cognate nuclear receptors critically modulate this maternal-fetal interaction that entails the initial success of procreation. While E is primarily involved in cell proliferation and acquisition …
-
Role of Dimerization in Binding of Estrogen Receptor to the Estrogen Response Element
… the role of dimerization in the binding of estrogen receptor to estrogen response elements. I found that the affinity of the estrogen receptor for the consensus estrogen response element is increased by six- to ten-fold by dimerization. This observation was true for both full length estrogen …
-
Expression of Human Estrogen Receptor and Studies of Estrogen-Mediated Transcription and Apoptosis
E2 and the antiestrogen OHT, each induce apoptosis in stably transfected hER positive HeLa-ER5 cells. Using transient transfections and a reporter system to measure p38 activity, we show that E2 induces the p38 activity 12--36 fold in several ER positive cell lines, while OHT induces p38 activity …
-
Estrogen action in the myocardium
… This observation has directed the attention to estrogen as a potential protective factor in the heart. So far the focus of research and clinical studies has been the vascular system, leaving the current knowledge on the role of estrogen in the myocardium itself rather scarce. Functional estrogen …
-
Estrogen Signaling in Trigeminal Nociception
… models of chronic pain, and is also activated by estrogen in sensory neurons. We used an established model of inflammatory trigeminal pain, injection of Complete Freund's adjuvant (CFA) into the masseter muscle, to determine whether ERK activation may play a role in hormone-related trigeminal pain …
-
Estrogen Receptor Subtype Selective Ligands
Estrogen action is mediated through estrogen receptor alpha (ERalpha) and beta (ERbeta). We report on the identification of several groups of non-steroidal ligands that show pronounced subtype-selective differences in ligand binding and transactivation potency or efficacy, the study of the …
-
The Effects of Estrogen Receptor -Alpha, Estrogen and Phytoestrogen on Global Myocardial Ischemia -Reperfusion Injury
The effects of estrogen receptor-alpha on myocardial ischemia-reperfusion injury were investigated in male estrogen receptor-alpha knockout (ERKO) and wild-type control mice (Control). The effects of estrogen and phytoestrogen were investigated in 6 control mice (Control). The effects of estrogen …
-
The Estrogen Response Element and the KRAB Repression Domain as Modulators of Estrogen Receptor Action
Repressing expression of estrogen regulated genes would greatly facilitate studies of their function. Therefore we transformed ER into a transcription repressor by fusing the KRAB transcription repressor domain of the Kox1 protein to ER and various ER mutants. Incorporation of DBD mutations …
-
Molecular actions of estrogen agonists and antagonists and their interaction with the human estrogen receptor
… were undertaken to examine the interaction of estrogen agonists and antagonists with the human estrogen receptor (ER) and to examine the consequences of this interaction on the DNA binding and transactivating ability of the receptor. The functional role of cysteines in the hormone binding …
-
Interplay Between Estrogen Response Element Sequences and Ligands Controls Binding of Estrogen Receptor to Regulated Genes
Dissecting the mechanism of estrogen receptor-mediated transcription is essential for understanding diseases ranging from breast cancer to osteoporosis. Central to estrogen receptor (ER)-dependent gene activation is the interaction of ER with its DNA recognition sequence, the estrogen response …
-
Control of Estrogen Receptor Concentration in the Rat Uterus Under Basal Conditions and After Estrogen Treatment
Made available in DSpace on 2014-12-11T22:22:11Z (GMT). No. of bitstreams: 1 7114936.pdf: 3558383 bytes, checksum: d6944f41a4e4682b0d205e37cfcb331b (MD5) Previous issue date: 1970
-
Estrogen in ovarian cancer cell metastasis
… cancers possess steroid receptors including estrogen receptors (ERs). However, the estrogen-ER signaling in ovarian carcinomas is not completely understood. Tumorigenesis is a multiple-step process involving dysregulated cell growth and metastasis. Tumor cells acquire the capacity of …
-
Estrogen receptor beta modulates prostate carcinogenesis
… influencing AR can modify disease progression. Estrogen is essential for prostate carcinogenesis with evidence from epidemiological, in vitro, human tissue and animal studies. Most suggests that estrogen receptor beta (ERβ) is tumour-suppressive, but trials of ERβ-selective agents have not …
-
Tissue-Specific Mediation of Estrogen-Induced Epithelial Events by the Estrogen Receptor in Female Reproductive Tract Organs
Estrogen receptor-alpha (ERalpha), which mediates the normal uterine and vaginal epithelial proliferative and differentiative effects of 17-beta estradiol (E2), is present in both stroma and epithelium of female reproductive tract organs. Although, the epithelial response to E2 has been assumed to …
-
Cross-Modulatory Actions of Estrogen Receptor Beta on Estrogen Receptor Alpha Transcriptional Activity in Breast Cancer Cells
Our observations indicate that the ability of ERalpha and ERbeta to serve as determinants of gene expression is greatly influenced by the nature of the ligand, ligand dose, and the ability of ligand-ER complexes to recruit coregulators at ER binding sites of hormone-regulated genes.
Page 1 of 42