Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"estimated glomerular filtration rate"”.
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Investigation of novel biomarkers associated with renal disease
… and measures of renal function and damage (estimated glomerular filtration rate and urinary albumin to creatinine ratio). Retinal biomarkers have previously been associated with the most significant causes of chronic kidney disease (CKD), hypertension and diabetes, and the most important …
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Association of variants in APOL1, MYH9 and HMOX1 WITH micro-Albuminuria among Sickle Cell disease patients from Cameroon
… genetic variants in MYH9 and APOL1, and between estimated Glomerular Filtration Rate (eGFR) and End Stage Kidney Disease (ESKD) with HMOX1 variants among adult African Americans affected by SCD. However, the association between these variants and micro-albuminuria, a primary indicator of renal …
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Retrospective comparison of cyclophosphamide and mycophenolate mofetil in lupus nephritis at Groote Schuur Hospital nephrology unit
… baseline, there were significant differences in estimated glomerular filtration rate (eGFR) and presence of glomerular crescents between both groups (p ≤ 0.05). After completion of induction therapy, there was no significant difference in remission status (76.0% versus 87.5%; p = 0.33) or relapse …
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Evaluation of an Advanced Practice Nurse Led Inter-professional Collaborative Chronic Care Approach for Kidney Transplant Patients: The TARGET Study
… model included the co-variates: a) estimated glomerular filtration rate, b) age, c) sex, d) kidney donor type, and e) diagnosis of diabetes. Based on the CCM elements and CKD clinical practice guidelines, the intervention included strategies for patient disease self-management, …
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Prevalence, Outcome, and Predictors of Cardiorenal Syndrome in Children with Dilated Cardiomyopathy
… (PCMR) were assessed. CRS was defined as estimated glomerular filtration rate (eGFR) <90 ml/min/1.73m2 by modified Schwartz formula. Patients with eGFR>150 ml/min/1.73m2 were excluded. CRS prevalence was determined by cross-sectional design in patients newly diagnosed with DCM using the …
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Renal and Blood Pressure Effects of Xanthine Oxidase Inhibitors in the FAST trial
… or the patient is taking their maximum tolerated dose of allopurinol. This analysis of FAST patients looked at the proportion of patients who required up-titration, the number of up-titrations required and any associated side effects. 2) FAST Blood Pressure Sub-Study. Home monitored blood …
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Identifying Observational and Causal Factors for Cardiovascular Diseases through Large-scale Cohorts
… the Framingham Heart Study helped scientists generate new knowledge on risk factors for cardiovascular diseases. While these data sources set in motion the decline in age-adjusted cardiovascular disease seen over the last five decades, they were limited by their size in the kinds of research …
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A comparison of clinical, biochemical, and histological characteristics as well as evaluation of outcomes of patient with mesangiovapillary glomerulonephritis (MCGN) in HIV positive and negative patients at a tertiary hospital in Cape Town, South Africa
… (MCGN) is a common histological pattern of glomerular injury in developing countries. South Africa has the highest proportion of people living with HIV (PWH) and the co-existence of MCGN and HIV may affect kidney prognosis. The aim of this study was to compare the clinical and biochemical …
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CELLULAR AND MOLECULAR MECHANISMS OF AT2R MEDIATED ANTI-PROTEINURIC ACTIVITY
… prevented by C21. Moreover, the expression of glomerular slit diaphragm proteins (nephrin and podocin) the estimated glomerular filtration rate remained unaffected which together suggest that HSD intake caused tubular proteinuria. The in vivo findings in megalin recycling impairment were …
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Modelling Renal Function in Drug Pharmacokinetics
… function is presented, defined by the ratio of estimated glomerular filtration rate (GFR) to normal GFR. It provides a continuous variable from neonates to adults that accounts for size, maturation and body composition consistently. This model is applied to a population PD analysis investigating …
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Clinical characteristics of end stage renal disease patients at hemodialysis initiation
The starting time of renal replacement therapy (RRT) is a complicated issue, which is based on multiple factors including clinical, social and laboratory parameters. To help make decision on when to start hemodialysis in impending end stage renal disease (ESRD) patients, we investigated the …
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MDRD 추정 사구체 여과율만으로 만성 신질환으로 분류되는 군의 임상적 의미
… kidney disease) stage에 따라 stage 3~5는 eGFR (estimated glomerular filtration rate)이 60 ml/min/1.73m2 미만인 경우 신손상의 유무와 무관하게 CKD로 분류된다. 본 연구에서는 혈청 크레아티닌이 정상이면서 혈뇨와 단백뇨가 없는 대상 중 eGFR의 감소만으로 CKD로 분류되는 군의 임상양상에 관해 알아보고자 하였다. 방법: 본 연구는 아주대학교 병원 건강검진센터에서 1998-2008년까지 검진을 받은 사람들의 검진 결과를 후향적으로 분석하였다. 연구 …
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The relationship between reduced renal function and cardiovascular disease
… (NORDIL). In study 1 we tested creatinine, estimated glomerular filtration rate (eGFR) with Cockroft-Gault (CG) and the MDRD equations and also microalbuminuria (MA) as predictors of CVD, stroke and CVD death. In Study 2 we tested cystatin C and compared it to eGFR estimated with the MDRD, …
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The Clinical Determinants of Plasma β-amyloid and Its Association with Structural and Functional Vascular Changes
… T2DM and non-T2DM sub-groups, renal function as estimated by estimated glomerular filtration rate (eGFR) was the most significant independent predictor of plasma β-amyloid 40 and 42 levels. In the T2DM subgroup, insulin use was also found to be independently associated with increased β-amyloid 40 …
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A comprehensive study of the impact of contrast medium on endothelial cells in vitro: validating the protective effects of n-acetylcysteine and assessing the importance of endothelin-1 and glutathione on contrast-induced nephropathy in patients with chronic kidney disease
… only when GSH was depleted. These results demonstrated, for the first time, a significant increase in ET-1 levels in a GSH depleted EA.hy926 cell model, exposed to CM, which set the stage for exploring the effects of CM on plasma ET-1 levels in patients with chronic kidney disease (CKD) undergoing …
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The impact of social deprivation on development and progression of diabetic kidney disease
… I used linear mixed effect models to calculate rate of decline in renal function using longitudinal estimated glomerular filtration rate (eGFR) data. I examined baseline clinical variables such as diabetes duration, smoking status, body mass index (BMI), systolic blood pressure (SBP), …
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Epidemiology and clinical outcomes of patients with idiopathic membranous glomerulonephritis at Groote Schuur Hospital over a ten year period
… Cox-Regression analysis. The trend in estimated glomerular filtration rate over the median duration of follow-up was evaluated as a secondary outcome. RESULTS: There were 56 patients with histologic and clinical parameters compatible with the diagnosis of IMGN. There were 26/56 females …
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Pharmacogenetics of Tenofovir (Alafenamide or Disoproxil Fumarate Prodrug) Renal Toxicity in HIV positive Black Southern Africans
… is more likely with tenofovir disoproxil fumarate (TDF) than with tenofovir alafenamide (TAF). Limited previous studies suggest potential genetic associations with TDF-associated renal toxicity. We hypothesized that polymorphisms in genes of potential relevance to tenofovir, TDF and TAF …
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Do percutaneous nephrostomies for malignant obstructive uropathy improve renal function six months post intervention?
… of this study was to assess the changes in estimated glomerular filtration rate (eGFR) over the first six months following percutaneous nephrostomy for malignant ureteric obstruction. We also explored the role of UTIs in the changes of eGFR following PCN. Materials and Methods We performed a …
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Renal and Cardiovascular Outcomes Associated with Cannabis Use in Veterans with Advanced Chronic Kidney Disease Transitioning to Dialysis
… outcomes, including both long-term changes in estimated glomerular filtration rate (eGFR) and the incidence of AKI. We used mixed-effects models with random intercepts and slopes and logistic regression to examine the association between UTOX groups and the risk of change in eGFR and AKI, …
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