Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"essential thrombocythaemia"”.
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The human myeloproliferative disorders: molecular pathogenesis and clonal heterogeneity
… myeloproliferative disorders (MPD), comprising essential thrombocythaemia (ET), polycythaemia vera (PV) and idiopathic myelofibrosis (IMF), are clonal premalignant haematopoietic neoplasms associated with activating mutations in signalling pathway molecules and a variable tendency to develop …
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The molecular pathogenesis of myeloproliferative neoplasms
… vera (PV) and 50-60% of cases of essential thrombocythaemia (ET) and primary<br/>myelofibrosis (PMF) are characterised by a single acquired mutation, JAK2 V617F. My study has<br/>focused on four principal areas:<br/><br/>(i) Involvement of V617F in other myeloid disorders. After …
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Detection of the calreticulin type 1 and type 2 mutations in a group of myeloproliferative neoplasm patients using molecular methods
… MPNs: polycythaemia vera (PV), essential thrombocythaemia (ET) and primary myelofibrosis (PMF) or myelofibrosis (MF). In 2013, somatic mutations at exon 9 of CALR, the gene that encodes for calreticulin, were discovered through whole-exome sequencing and targeted re-sequencing in …
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Cytokine receptor-like factor 3 (CRLF3): A novel regulator of platelet biogenesis and potential drug target for thrombocythaemia
Thrombocythaemia is defined as a circulating platelet count above 450x10$^9$/L in humans. The major cause of thrombocythaemia is reactive $(secondary)$ thrombocythaemia which occurs secondary to many conditions such as infection, cancer and inflammation. However, acquired clonal mutations in mainly …
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Gene expression profiling of patients with Polycythaemia Rubra Vera using cDNA microarrays
… of PV. The characterization of 48 patients with essential thrombocythaemia (ET) with respect to the markers PRV-1 mRNA, c-Mpl protein, clonality and EEC-growth was also part of this work. As a result it turned out that elevated PRV-1 mRNA and decreased c-Mpl protein expression are acquired …