Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"esophageal cancer"”.
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Transcription regulation and candidate diagnostic markers of esophageal cancer
Esophageal cancer (EC) ranks among the ten most frequent cancers worldwide. Mortality rates associated with EC are very similar to the incidence rates due to the relatively late stage of diagnosis and the poor efficacy of treatment. The aim of this study was to enhance our insights of putative …
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Quantitative Dwi As An Early Imaging Biomarker of The Response to Chemoradiation In Esophageal Cancer
<p>For patients diagnosed with stages IIa-IIb esophageal cancer, the current standard of care treatment is tri-modality therapy (TMT), where neoadjuvant chemoradiation (nCRT) is followed by surgical resection. Histopathology of resected tumors reveals that pathological complete response (pCR) is …
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Enhanced evaluation of RNA expression in Esophageal Cancer tissues: Combining Microarray and RNA-Sequence approaches
Esophageal1 cancer (EC) is a serious global health challenge, associated with high mortality rates and limited advances in early detection. The two predominant malignant subtypes, esophageal1 squamous cell carcinoma (ESCC) and esophageal1 adenocarcinoma (EAC), arise through distinct biological and …
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Novel tissue- and blood-based biomarkers in Barrett’s Esophagus and esophageal adenocarcinoma
Esophageal cancer is one of the most aggressive tumors ranked as the seventh most common cancer worldwide and sixth in cancer-related mortality overall. The overall 5-year survival in the high-income countries for patients diagnosed with esophageal cancer is less than 20%. The first part of my …
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Multimodal Optical Imaging for Tissue Characterization and Disease Diagnosis
Epithelial cancers are among the most dangerous forms of cancer. Of this broad group of disease, ovarian and esophageal cancer are particularly deadly, with five-year survival rates of less than 50% and 20% respectively. The primary cause of this low survival rate is due to predominantly late …
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Advances in the endoscopic management of esophageal neoplasia using ultrahigh speed endoscopic optical coherence tomography
Esophageal cancer is one of the most lethal malignancies, with a five-year survival rate of only 16.7%. Barrett's esophagus (BE) is a premalignant condition with increased risk of developing into esophageal adenocarcinoma, the most common type of esophageal cancer in the West. In current BE …
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Volumetric Optical Imaging of Tissue Microstructure for Grading of Dysplasia In Vivo
… of epithelial nuclei with the progression of esophageal dysplasia. In this thesis research, we investigate the application of novel signal processing methods and custom OCT hardware to uncover biomarkers of dysplasia based on these pathological changes in cell nuclei. Further, we apply our …
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Development of Novel Instrumentations and Algorithms for Optical Screening of Epithelial Dysplasia
<p>Esophageal cancer is a very aggressive form of cancer, and in the past decade, the incidence rate of esophageal cancer is rising faster than any other malignancy in the U.S. Luckily, most precancers are preventable given timely surveillance and proper treatments. Despite the recent success of …
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Mechanisms Underlying Alcohol-Mediated Cellular Injury In Esophageal Keratinocytes
Esophageal squamous cell carcinoma (ESCC) is the 6th deadliest cancers worldwide. Although it is more prevalent in eastern world, it accounts for 90% of esophageal cancer worldwide. Late stage diagnosis and resistance to therapy has resulted in a poor 5-year survival rate of 20%. Alcohol …
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Near real-time early cancer detection using a graphics processing unit
<p>"Automatically detecting early cancer using medical images is challenging, yet very crucial to help save millions of lives in the early stages of cancer. In this work, we improved a method that was originally developed by Yamaguchi et al. from the Saga University in Saga Japan. The original …
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Investigation of cellular microenvironments and heterogeneity with biodynamic imaging
… of chemotherapeutic agents in combatting cancer. Though many three-dimensional (3D) culture models exist, conventional <em>in vitro</em> assays continue to use two-dimensional (2D) cultures because of the difficulty in imaging through deep tissue. 3D tomographic imaging techniques exist …
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Biological Functions of Iduronic Acid in Chondroitin/Dermatan Sulfate in Tumor and Brain Development
… migration and proliferation, especially during cancer development, are balanced by the surrounding environment. Complex polysaccharides called glycosaminoglycans (GAGs) are part of this environment and they are known to modulate tumor development. One of these GAGs, dermatan/chondroitin sulfate …
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The Impact of Vitamin D on the Epidemiology, Pathogenesis, and Treatment of Esophageal Adenocarcinoma
Esophageal adenocarcinoma is now the most common form of esophageal cancer, and the prognosis for patients with this disease is poor. Understanding the mechanisms of disease development through premalignant Barrett’s esophagus, a consequence of GERD, and factors predicting a positive response to …
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Hereditary and inborn etiology of pediatric cancer
The etiology of childhood cancer remains largely elusive. In rare cases, genetic mutations and environmental exposures such as radiation are known causes. For the vast majority of childhood cancer patients, there is no known cause for their disease. With an increasing number of childhood cancer …
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Natural product derivative activates autophagy in cancer cells
… antimalarial compounds, which have shown anticancer activity. In this study, we further characterized a novel artemisinin derivative namely EXP57EA which was previously designed and synthesized by the Chemistry Department at the University Of Cape Town. We determined the effect of EXP57EA on a …
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Investigating mitochondria alterations in esophageal pathologies
Esophageal squamous epithelium possesses a defined proliferation-differentiation gradient essential for barrier function, the primary defense against luminal contents such as food allergens and carcinogens. This barrier is perturbed in esophageal diseases, including eosinophilic esophagitis (EoE), …
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Decoding Treatment Resistance and Genotype-Phenotype Interactions at Single Cell Resolution
<p>Understanding how cancer cells and their tumor microenvironment (TME) mediate chemoradiation (CRT) resistance in esophageal adenocarcinoma (EAC) is key for improving the low treatment response rate in the clinic. Here, we generated single cell transcriptomics data of 302,035 cells from N=83 …
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PROGRESS IN CANCER INCIDENCE, MORTALITY, AND SURVIVAL
Cancer mortality has declined over the last three decades in most high-income countries reflecting improvements in cancer prevention, diagnosis, treatments, and management. However, there are persisting and substantial differences in mortality, incidence, and survival worldwide. Using the World …
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Korrelation des präoperativen physischen Status und prädiktiver Parameter mit perioperativer Morbidität, Mortalität und Langzeitüberleben nach Ösophagusresektion
HINTERGRUND: Die Ösophagusresektion mit Lymphadenektomie und Speiseröhrenersatz ist nach wie vor die zentrale Säule in der kurativen Therapie des Ösophaguskarzinoms, allerdings geht mit der Größe des Eingriffs auch ein relativ hohes Risiko perioperativer Morbidität und Mortalität einher. Bezüglich …
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Developing scaffolds for full-thickness esophageal replacement
L'abstract è presente nell'allegato / the abstract is in the attachment