Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"erythroid progenitors"”.
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The Role of Adenosine Signaling In Mature Erythrocytes and Erythroid Progenitors
… its significance and functional role in the erythroid lineage, particularly under stress conditions, are still unclear.</p> <p>My dissertation employing multi-disciplinary approaches including human studies, novel genetic tools, and sophisticated pharmacological studies coupled with …
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The roll of integrins in hematopoiesis
… cells at two developmental stages. In the erythroid lineage, I show that expansion of committed erythroid progenitors is regulated by growth factor and integrin-mediated signals in temporally distinct regimes. I establish a biologically relevant role for [alpha]401 but not [alpha]501 …
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Effect of CDDO-me on Myelopoiesis in Naive Mice and Mice Undergoing Bone Marrow Transplantation (BMT)
… μg/ dose, BID) significantly increased myeloid, erythroid, and CFU-HPPs in the spleen and the bone marrow. In addition to inducing CFU-GM expansion, treatment with CDDO-me caused a significant increase in myeloid and erythroid progenitors in the spleen and blood. The level of G-CSF in the serum …
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MicroRNA Function in Cellular Stress Response
… the regulation of oxidative stress response in erythroid cells and the functional consequences of dysregulated microRNA expression in Sickle Cell Disease (SCD) pathobiology. The second study examines a functional role for microRNA in the cellular response to changes in cellular iron …
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Studies on the specificities of <i>In Vivo</i> and <i>In Vitro</i> bioassays used in the potency determination of Therapeutic Erythropoietin
… the proliferation and differentiation of erythroid progenitors into mature red blood cells.<br></br><br></br>The <i>in vivo</i> biological activity of Epo is dependent on it being adequately glycosylated. Glycosylation is a variable process and its precise effect on clearance mechanisms …
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Ubiquitination of EpoR and p85 in Ligand Induced EpoR Down-Regulation
… and signals through its receptor, the EpoR, on erythroid progenitor cells. Epo binding to EpoR activates Janus kinase 2 (JAK2), which phosphorylates cytoplasmic tyrosines of the EpoR. Signaling proteins bind these phosphotyrosines through SH2 domains, leading to the survival and proliferation of …
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Novel roles of KAT2A chromatin complexes ATAC and SAGA in normal and malignant haematopoiesis
… Firstly, I demonstrate that KAT2A regulates CB erythroid progenitor specification and survival. I uncover unique contributions of the ATAC complex to erythroid lineage specification, whereas SAGA acts late in differentiation. This suggests that KAT2A plays stage-specific roles, which are unique …
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Generation and Characterization of a Knock-In Allele of EKLF: Probing the in vivo Role of the Chromatin Remodeling Domain in Definitive Hematopoietic Cells
… zinc finger-encoding transacting factor EKLF, or erythroid Krüppel-like factor, binds key regulatory elements of many erythroid-specific genes, and is essential for definitive erythropoiesis. Mice lacking this factor die of anemia by E15.5 of gestation, failing to activate β-globin gene …
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Charting the single-cell transcriptional landscape of haematopoiesis
… the gene expression of many haematopoietic progenitors has been measured. However, many of the classic populations are actually extremely heterogeneous in both expression and function, highlighting the need for characterising the haematopoietic progenitor compartment at the level of …
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The Role of Meis1 in Hematopoietic Development
… shown to give rise to definitive hematopoietic progenitors. This suggested the potential that <italic>Mesp1</italic> activity in endothelium might influence subsequent hematopoietic development. Although <italic>in vitro</italic> studies indicated that <italic>Mesp1</italic> acted to suppress …
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Niche disturbances in Chronic Lymphocytic Leukaemia affect HSC residency and drug resistance
… that short term (ST) HSCs and Common Myelo-Erythroid Progenitors (CMP/MEPs) are found in higher frequencies and are associated with a skewed differentiation into myeloid cells in vitro and progenitor cells are less likely to produce erythrocytes. These findings provide evidence for the …
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From yeast to animals: A small molecule restores iron mobilization, absorption and hemoglobinization
… hemoglobinization in DMT1- and Mfrn1-deficient erythroid progenitors, and iron release from FPN1-deficient gut epithelia and reticuloendothelial macrophages. To test the hypothesis that deficiencies of iron transporters lead to a build-up of labile iron upstream of protein-deficient membranes, …
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Single-cell Protein-Transcriptome Atlas of Haematopoiesis across the Human Lifespan
… presence of eosinophil, basophil, and mast cell progenitors compared to other tissues. Distinct differences in cell proportions for myeloid groups like megakaryocyte progenitors, myeloid-erythroid progenitors, and common lymphoid progenitors were observed between yolk sac and the other examined …
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Ein neuer und ungewöhnlicher Signalweg erlaubt physiologischen Konzentrationen von Erythropoetin mitogene Kinasen in primären erythroiden Vorläuferzellen zu aktivieren
Die Stimulation primärer erythroider Vorläuferzellen (PEPs) mit Erythropoetin (Epo) führt zur Aktivierung der mitogenen Kinasen („extracellular signal-regulated kinases“ (Erks) und „mitogen-activated protein kinase/Erk-activating kinases“ (MEKs)). Der Mechanismus der Aktivierung war bisher unklar. …
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Mobilisation, Isolation and Coculture of Haematopoietic Stem Cells
… with increased levels of circulating CD34+ progenitors. In our study (part 2 of the chapter “Results and discussions”), we compared circulating HSCs from MS patients after natalizumab treatment and HSCs mobilized by G-CSF in healthy volunteers, with regard to their migratory potential, …
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The role of GATA-1 isoforms in haematopoiesis
… plays a pivotal role in differentiation of the erythroid, megakaryocytic, eosinophilic, mast cell and dendritic cell lineages. Since its initial cloning and characterisation in 1989 a huge amount of information has been gathered on the molecular mechanisms of action of GATA-1. This knowledge has …