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Showing 1 to 20 of 63 for “"ergosterol"”.
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Amphotericin B extracts ergosterol faster than fungi can make it
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-05-01
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Targeting CYP5122A1 and CYP51 for the Inhibition of Ergosterol Biosynthesis in Trypanosomatids
… safe, effective, and affordable drugs. Targeting ergosterol biosynthesis has been considered a promising strategy for the development of new anti-trypanosomatid agents. Cytochrome P450 (CYP) 51 acts as a sterol C14α-demethylase during ergosterol biosynthesis and has been widely studied for its …
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The regulation of yeast homotypic vacuole fusion and membrane trafficking events by sphingolipids, ergosterol, and lipid rafts
… phospholipids with saturated acyl chains, and ergosterol. Recent studies have shown that these lipid rafts contain an enrichment of many different proteins that function in essential activities such as nutrient transport, organelle contact, membrane trafficking, and homotypic fusion, suggesting …
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Influence of Varying Inorganic Nutrients Supply on Ergosterol and Glucosamine Concentrations and Biomass Nutrient Stoichiometry in Ectomycorrhizal Fungi
… examined nutrient and ratio effects on fungal ergosterol and chitin concentrations, which are important biochemical indicator molecules used to assess fungal biomass in environmental samples. Ergosterol and chitin concentrations in fungal dry mass differed significantly between species with no …
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Structure and Dynamics of Biomembranes containing Cholesterol and other Biologically-Important Sterols : a computational perspective
… effects of three closely-related sterols: ergosterol, cholesterol and lanosterol on the structural and dynamical properties of a model dipalmitoyl phosphatidylcholine (DPPC) membrane were examined using Molecular Dynamics (MD) simulations and Neutron Scattering (NS) calculations. As a …
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The Molecular Mechanisms of Antifungal Drug Resistance In Pathogenic Fungi
… of ERG11, which is a rate-limiting enzyme in the ergosterol biosynthetic pathway. Other antifungals also target the ergosterol pathway, including fenpropimorph,(morpholine) which targets Erg24p, and terbinafine (allylamines), which targets Erg1p enzymes. Aberrant levels of ergosterol may affect …
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Domain Redistribution in Lipid Bilayers in the Presence of the Antimicrobial Lipopeptide Fengycin
… photobleaching. Using this optimized protocol, ergosterol was incorporated into the bilayers and domain redistribution was evaluated after the addition of fengycin. SLBs containing higher concentrations of ergosterol were more tolerant to changes induced by fengycin. Following the analysis of …
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Endosomal Trafficking as a Determinant of Antifungal Tolerance in the Pathogenic Fungus Candida albicans
… antifungal drugs inhibit the synthesis of ergosterol, a lipid that modulates the thickness, fluidity and permeability of fungal cell membranes. These include the azole antifungals, which block ergosterol biosynthesis by inhibiting lanosterol demethylase (Erg11p). The resulting depletion of …
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Characterization of Mycochemicals and Bioactivities of a New Zealand Native Mushroom Hericium novae-zealandiae
… B (another compound unique to Hericium), ergosterol and ergosterol peroxide. The contents of hericene B and ergosterol were determined as 28.53 and 2.09 mg/g dry weight, respectively. The polysaccharides possessed anti-proliferative activity on PCa cell lines. Subsequently, it was …
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Synthese des antimykotisch aktiven Steroid-Alkaloids Plakinamin B - Azasteroide als Inhibitoren der Sterol-C-24-Methyltransferase
… Aktivität in einem Agar-Diffusionstest; Ergosterol-Biosynthese-Inhibitor-Screening und Bestimmung des jeweiligen Zielenzyms; Ableitung von Struktur-Wirkungs-Beziehungen.
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Studies on fungal biomass and activity associated with the decomposition of plant litter in freshwater
… estimating fungal biomass was developed using ergosterol as a marker. Conversion factors for ergosterol and biovolume to fungal biomass were shown to vary with fungal species, age and growth conditions, but no single parameter was found which could adequately explain this. In field studies on …
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Electronic tuning of site selectivity and semisynthesis of C2'-deoxyamphotericin B
… channels and mediating a direct interaction with ergosterol. The discovery that AmB directly binds ergosterol pointed to two possible primary mechanisms, membrane permeabilization through channel formation or ergosterol sequestration. The C35 hydroxyl group on AmB has been predicted to be …
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Loss of the SAC Components SldA Kinase or SldB or in vitro Adaptation to Triazole Produces Aneuploidy Associated with Triazole Heteroresistance in Aspergillus fumigatus
… (IA), target the fungal biosynthesis of ergosterol, a vital component of the fungal cell membrane. Unfortunately, resistance to this class of medical therapeutic has arisen globally and now threatens the future usefulness of these compounds for antifungal treatment. Infection with A. …
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Analysis of the effect of atorvastatin on the virulence of Fungal Pathogens
… for the production of cholesterol in humans and ergosterol in fungi. The aim of the work presented here was to analyse the antifungal activity of a widely prescribed statin (atorvastatin) and assess the effect of atorvastatin on the on the virulence of C. albicans and A. fumigatus. The study also …
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Characterisation of the Microbial Community in Indoor Environments: a Chemical-Analytical Approach
… (muramic acid), and fungal biomass (ergosterol). A hydrolysate of 13C-labelled cyanobacterial cells was used as an internal standard for the first three markers (13C-labelled 3-hydroxytridecanoic acid from labelled Pectinatus cerevisiiphilus was used as an alternative internal …
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Impacts of the Deepwater Horizon Oil Spill on Microbial-Mediated Cellulose Decomposition in Mississippi Gulf Coast Salt Marshes
… rates of microbial respiration, fungal biomass (ergosterol) and nutrients (C:N, C:P) of surface sediment cotton strips were also quantified. Subsurface cotton strip decay, as determined by losses in tensile strength, were significantly different among marsh sites, with higher overall rates being …
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Modulation kollektiver Membrandynamik im mesoskopischen Bereich durch Einbau und Adsorption von Biomolekülen
… bedeutsamsten Steroide Lanosterol, Ergosterol und Cholesterol auf die kollektive Membrandynamik studiert. Ziel war es, die möglichen Korrelationen zwischen der molekularen Struktur der Steroide und den makroskopischen Funktionen der Komposit-Membranen zu identifizieren. Die drei …
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Comparative efficacy of azole compounds targeting sterol 14-demethylase against multiple isolates of Acanthamoeba castellanii and polyphaga
… better drugs and treatments are required. Ergosterol is a sterol found both in fungi and certain strains of amoeba including Acanthamoeba spp. but does not occur in animals, it is a vital part of the membrane serving the same function as cholesterol in mammals this renders its synthesis an …
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Využití vybraných molekulárních metod k metabolické charakterizaci průmyslově významných kvasinek
Karotenoidy, ergosterol a mastné kyseliny jsou velmi žádané látky využívané v krmivářském, potravinářském a kosmetickém průmyslu. Konvenční zdroje mastných kyselin a karotenoidů jsou závislé na sezónních podmínkách, geografické poloze a na dostupnosti zemědělské půdy, což znesnadňuje pokrýt jejich …
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