Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"epsin"”.
-
ROLE OF THE ENDOCYTIC PROTEIN EPSIN 3 IN MAMMARY GLAND TRANSFORMATION
… We previously showed that the endocytic protein Epsin 3 (EPN3) is overexpressed in 50% of breast cancers (BC) and amplified in approximately 10% of cases. EPN3 overexpression correlates with increased tumor invasiveness and distant metastasis. Interestingly, the well-characterized oncogene ERBB2 …
-
Ubiquitination of EpoR and p85 in Ligand Induced EpoR Down-Regulation
… EpoR. Ubiquitination allows p85 to interact with epsin-1, thereby driving EpoR endocytosis. Knockdown of Cbl, expression of its dominant negative forms, or expression of an epsin-1 mutant all compromise Epo-induced EpoR internalization. Mutated EpoRs mimicking those from PFCP patients cannot bind …
-
Atomistic and Coarse-Grained Investigation of Membrane-Protein Interactions
… affinity of a membrane-remodeling protein (epsin) to membranes subjectedto high tension. We performed umbrella sampling calculations to provide the first quantita-tive evidence that tension energetically promotes the insertion of a transmembrane helicaldomain of epsin. Next, we embarked on …
-
EHBP1 and EHD2 Regulate Dll4 Caveolin-Mediated Endocytosis During Blood Vessel Development
… time in endothelial cells that the proteins Epsin homology domain protein 2 (EHD2) and EHD2 binding partner 1 (EHBP1) regulate Delta like ligand 4 (Dll4) endocytosis by tethering its caveolar endocytic pit to the actin cytoskeleton.</p>
-
Structural characterization of interaction of K11 and K63 mixed-linkage polyubiquitin chains with the tUIMs of epsin1
… as endosomal sorting for lysosomal degradation. Epsin1 is an endocytic adaptor protein with three tandem UIMs (Ubiquitin Interacting Motifs) which are responsible for the highly specific interaction between epsin and ubiquitylated receptors. Epsin1 is also an oncogenic protein and its expression …