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Showing 1 to 20 of 171 for “"epoxide"”.
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Synthesis and properties of lignin epoxide
A lignin epoxide resin was synthesized and characterized. The epoxidation reaction was studied by reacting hydroxypropylated guaiacol (a lignin-like model compound) and epichlorohydrin using a catalyst system of potassium hydroxide and a phase transfer catalyst in toluene. The parameters studied …
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Endo-selective epoxide-opening cascades in water
… is their biogenesis. Cascades of endo-selective epoxide opening inspired by the biosynthetic proposal and promoted by simple neutral water can provide efficient access to these compounds. Chapter II. Water-Promoted Epoxide Opening Accommodates Methyl Substitution. ... Methyl (Me) substitution …
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Directing group-free endo-selective epoxide-opening cascades
… ladder polyethers features a dramatic series of epoxide opening reactions, elegantly accounts for the structural and stereochemical features of all related natural products, and, in principle, could significantly simplify the synthesis of these extraordinarily complex molecules. In practice, …
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The bioactive role of omega-3 endocannabinoid epoxide regioisomers
… (EDP-EAs) that are known as omega-3 eCB epoxides. Previously, 17,18-EEQ-EA and 19,20-EDP-EA have shown to have anti-neuroinflammatory, vasodilatory, anti-angiogenic properties, activate cannabinoid receptors and regulate platelet aggregation in vitro. Although these metabolites have …
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The Degradation and Stabilisation of Epoxide Resins to Ultraviolet Radiation
… changes which occurred on exposure of two epoxide resins, one amine and the other anhydride cured, to ultraviolet light. The method of study was by investigation of the changes in both cured resins and the monomers from which they were synthesised. Also, because of the intractable nature of …
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Rhodium-catalyzed epoxide-opening cascades toward brevisin and hemibrevetoxin B
CHAPTER I. Rhodium-Catalyzed Epoxide-Opening Cascades: Formal Synthesis of (-)-Brevisin [chemical formula inserted] [Rh(CO)₂Cl]₂ was found to be an effective catalyst for endo-selective cyclizations and cascades of epoxy-(E)-enoate alcohols, thus enabling the synthesis of oxepanes and …
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Synthetic Studies Towards the Gombaspiroketals and a Cobalt-Catalysed Epoxide Olefination
… were chosen as a target for synthetic studies. Epoxide 171 was identified as a possible intermediate towards the gombaspiroketals, which was envisioned to be accessed by Hosomi-Sakurai allylation of allylsilane 45 and cyclic acetal 172 followed by epoxidation. This work describes efforts in the …
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Synthesis, characterization and properties of epoxide containing block and alternating copolymers
The synthesis of epoxide containing block and alternating copolymers has been investigated in this research. Poly(ethylene oxide-2-ethyl-2-oxazoline) (PEO) copolymers have been synthesized with poly(ethylene oxide) macroinitiators ranging from O.75K-40K. Monohydroxy functionalized PEO oligomers …
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Quantification of benzo[a]pyrene-diol-epoxide adducts by laser-induced fluorescence spectroscopy
… adducts of benzo[a]pyrene-7,8-diol-9,10- epoxide (BPDE) in human lung tissue and human bronchial epithelial cell histones and DNA and in human serum albumin. The presence of BPDE adducts in human lung tissue and human bronchial epithelial cell histones and DNA was proven by cryogenic …
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Studies on the total synthesis of gambierol via endo-selective epoxide-opening cascades
… using water-promoted endo-selective epoxide-opening cascades to construct the poly-THP motifs. The concentration and temperature effects in the waterpromoted cascades were examined, and an operationally simple protocol was developed for the synthesis of polycyclic cascade products on …
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A study of the thermal degradation of model compounds of amine-cured epoxide resins
… of rr..odel compounds of a~ine-cur2d epoxide resins has been studied with the aim of investigating the thermal stability of the "cure-linkage". · 1, 3-Diphenoxypropan-2 ~ol and l-(N-ethylanilino)-3-phenoxypropan-2-ol have been synthesised and degraded m~er various conditions. The …
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Synthesis and evaluation of aziridine and symmetry-based epoxide affinity labels for HIV-1 protease
… protease. The synthesis of three symmetry-based epoxides and an aziridine analog of 1,2-epoxy-3-(p-nitrophenoxy)propane (EPNP) are reported. Assay procedures were developed to allow testing for both reversible and irreversible inhibition of HIV-1 protease, based on an internally-quenched …
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Nickel-catalyzed coupling reactions and synthetic studies toward ent-dioxepandehydrothyrsiferol via an epoxide-opening cascade
… studies of ent-dioxepandehydrothyrsiferol via an Epoxide-Opening Cascade Dioxepandehydrothyrsiferol is a marine polycyclic ether natural product isolated from the red algae Laurencia viridis.
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Bromonium-Initiated Epoxide-Opening Cascades : total Synthesis of ent-Dioxepandehydrothyrsiferol and Synthetic Studies toward (+)-Scholarisine A
CHAPTER I. Bromonium-Initiated Epoxide-Opening Cascades: Total Synthesis of ent-Dioxepandehydrothyrsiferol Our foray into the total synthesis of ent-dioxepandehydrothyrsiferol has led to the discovery and development of the bromonium-initiated epoxide-opening cascade. This transformation constructs …
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Development of a microwave-assisted epoxide aminolysis and investigation of the aza-cope rearrangement--mannich cyclization for alkaloid synthesis
… β-amino alcohols are prepared by ring opening of epoxides using an amine nucleophile and a catalyst or promoter. Ring opening can take place by the SN1 pathway or the SN2 pathway, but no single catalyst or promoter consistently gives SN2 selectivity. Additionally, long reaction times are often …
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Phosphine-promoted cross-coupling reactions of propargylcopper reagents and alkenyl iodides and the total synthesis of (-)-gloeosporone via nickel-catalyzed epoxide-alkyne reductive macrocyclization
… of (-)-Gloeosporone via Nickel-Catalyzed Epoxide-Alkyne Reductive Macrocyclization. The total synthesis of macrolide natural product (-)-gloeosporone 1 is described in 10 steps (LLS) and 5.2% overall yield. The key macrocyclization was performed via nickel-catalyzed reductive …
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Nickel-catalyzed preparation of acrylamides from alpha olefins and isocyanates ; Synthetic studies toward ripostatin A
… coupling reaction of enynes and epoxides developed in our laboratory, followed by rearrangement of the resulting dienylcyclopropane intermediate to afford the skipped 1,4,7-triene. ... A cyclopropyl enyne fragment corresponding to C1-C9 of ripostatin A can be synthesized in high …
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