Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"epitranscriptome"”.
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Activin/Nodal Signalling Controls the Epigenome and Epitranscriptome of Human Pluripotent Stem Cells
… by shaping both the epigenome and the epitranscriptome of hPSCs. Secondly, it provides a novel powerful technology to facilitate further studies of the mechanisms that regulate cell fate decisions.
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Epitranscriptomics : translational regulation of metabolism, drug resistance and proteostasis during cellular stress
The epitranscriptome -- the naturally occurring system of chemical modifications on ribonucleic acid (RNA) --
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An Inverse Electron-Demand Diels-Alder Strategy for Mapping RNA Methylation
… for further biocompatible reactions tailored for epitranscriptome analysis. To address this, this thesis details the development and systematic evaluation of a bioorthogonal strategy specifically designed to be advantageous for mapping RNA modifications. The foundational work was conducted in an …
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Selective Chemical Reactions for Nucleic Acid Sequencing and DNA-Encoded Library Synthesis
… to map methylation sites in the human genome and epitranscriptome has transformed our understanding of how these modifications govern and influence a host of cellular processes and human diseases. Amongst the most widely studied methylations is N6-methyladenine, known as 6mA in DNA and m6A in RNA. …
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THE EPITRANSCRIPTOMIC REGULATION OF STRESS: ROLE OF N6-METHYLADENOSINE IN ABIOTIC STRESS RESPONSE
… within the RNA molecules, also known as the epitranscriptome, have recently emerged as an important aspect of post-transcriptional gene regulation. More specifically, studies have shown that N6-methyladenosine(m6A), the most prevalent internal mRNA modification, can alter gene expression by …
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Transcriptome-wide pseudouridine profiling reveals modification of critical E. coli mRNAs
… it. In doing so, it expands the known bacterial epitranscriptome and provides insight into the ways RNA modifications are leveraged for gene regulation.
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The role of RNA modifications in mitochondrial translation
Mitochondrial gene expression entails multiple steps, one of which is translation, performed by the mitochondrial ribosome. Post-transcriptional RNA nucleotide modifications have been identified in mitochondrial (mt)-rRNAs. However, little is known about their role in terms of mitochondrial …