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Showing 1 to 7 of 7 for “"epitope prediction"”.
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B-Cell Epitope Prediction for Improved Antibody Docking
… as a regression problem, outputting a single prediction. We hypothesized that while the performance after a single try might be poor, the likelihood of producing a good docking pose in 𝐾 tries could be significantly higher. To achieve this without having to alter existing docking models, we …
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Evaluating the predictive performance of cytotoxic T lymphocyte epitope prediction tools using Elispot assay data
Computational T-cell epitope prediction tools have been previously devised to predict potential human leukocyte antigen (HLA) binding peptides from protein sequences. These tools are complements of Enzyme-linked immunosorbent spot (ELISpot) assays - a very commonly applied immunological technique …
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Communication at the Cellular Level: Discovery and Application
… to tackle the longstanding problem of B cell epitope prediction. Despite decades of effort and advancements in experimental and computational techniques, this problem remains challenging, with available tools performing only marginally better than random guess. Strikingly, the incorporation of …
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Computational Evaluation and Structure-based Design for Potentiation of Nicotine Vaccines
… the WT protein and then incorporating a multi-epitope insert that could universally target major histocompatibility complex (MHC) class II molecules. The proteins were subsequently expressed in E. coli and purified using a multi-step process. Comparisons between the separation outcomes revealed …
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In silico prediction of C57BL/6 mouse T-cell epitopes: enhancing immunogenicity assessment with PREDBL6
… MHC and recognized by T cells are called T-cell epitopes. MHC class I–restricted T cell epitopes play a crucial role in the immune surveillance of intracellular pathogens. As MHC binding is considered the most selective step in T cell recognition, many existing bioinformatics systems focus on …
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MOLECULAR DYNAMICS SIMULATIONS OF BIOLOGICAL MACROMOLECULES: APPLICATIONS TO STRUCTURAL VACCINOLOGY AND PEPTIDE DESIGN
… first one is about a computational method for epitope predictions on antigenic proteins, while the second one is related to the characterization of folding/unfolding processes of small natural polypeptides. Starting with the first topic, an increasing number of functional studies of proteins …