Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 368 for “"epitope"”.
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A Conserved epitope on the surface of carlaviruses
… plant component. Partial characterization of the epitope to which the antibody reacts was also accomplished. It is postulated that the epitope is conformational in nature, since the antibody fails to detect coat protein subunits in Western blots, and does not react to virus degraded by long-term …
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B-Cell Epitope Prediction for Improved Antibody Docking
… models, we propose to first train a B-Cell epitope predictor and to subsequently use it to produce a diverse set of candidate binding sites. Our epitope predictor achieves state of the art performance, with an ROC-AUC score of 76. We then show that, by properly post-processing the epitope …
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On Epitope-Paratope Interactions of Emerging to Endemic Viruses
… Viruses present numerous surfaces known as epitopes that are recognized by the human host immune system upon infection. Infected hosts develop antibodies that bind virus epitopes via the antibody’s paratope domain in an epitope-paratope interaction (EPI). EPIs are key aspects of the dynamic …
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Novel tools for sequence and epitope analysis of glycosaminoglycans
… sequence information and to quantify whole epitopes from GAG mixtures. Three complementary sets of tools were developed to provide GAG sequence information. Two novel exolytic sulfatases from Flavobacterium heparinum that degrade heparan/heparan sulfate glycosaminoglycans (HSGAGs) were …
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B CELL EPITOPE MAPPING OF RIVAX, A CANDIDATE RICIN VACCINE ANTIGEN
… and hence generating a comprehensive B cell epitope map of ricin toxin would not only help in evaluating future ricin vaccine candidates in humans but also provides an immunological rationale for designing new vaccine candidates. Previous studies have shown that toxin neutralizing antibodies …
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The Production and Characterization of a Monoclonal Antibody to a Naturally Occurring Aminomalonic Acid Epitope and a Comparison with an Antibody to a Synthetically Derived Aminomalonic Acid Epitope
… antibody combined with the uniqueness of the epitope and its presumed importance as an adhesion molecule vital for metastasis make this an interesting approach to cancer treatment.</p> <p>The mAb-Ama<sub>syn</sub> antibody (Ortho Diagnostic Systems Clone #57D4B6G2B11), developed by immunizing …
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Characterization of epitope-blocking ELISA for differential diagnoses of secondary flavivirus infections
… antibodies to compete actively in binding the epitopes on the NS1 peptides and to distinguish between antibodies induced by different flaviviruses. Developing a test distinguish between antibodies to different flaviviruses would significantly improve differential diagnostic capabilities, and …
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Evaluating the Impact of Antibody Epitope and Function on HIV-1 Vertical Transmission
… addition to reducing pathogenesis. The specific epitopes targeted by protective antibodies are also poorly defined. In this thesis, we sought to bridge these gaps by comprehensively examining whether antibody epitope or ADCC activity protect from HIV acquisition. In Chapter II, we sought to …
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HIV subtype C diversity: analysis of the relationship of sequence diversity to proposed epitope locations
… subtype C diversity and how it relates to CTL epitope location along viral gag sequences. We found a negative correlation between codon sites under positive selection and epitope regions; suggesting epitope regions are evolutionarily conserved. It is possible that epitopes exist in …
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Mapping the Major Epitope(s) of the Glycoprotein of Ebolavirus with QB Phage Display System
… analyze their antigenicity and to map the major epitope(s) of the glycoprotein determinants. This research study represents a proof of concept and will serve as a guide as to how to produce recombinant phages bearing large antigenic peptide segments of a viral protein and initiate its analysis. …
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Evaluating the predictive performance of cytotoxic T lymphocyte epitope prediction tools using Elispot assay data
Computational T-cell epitope prediction tools have been previously devised to predict potential human leukocyte antigen (HLA) binding peptides from protein sequences. These tools are complements of Enzyme-linked immunosorbent spot (ELISpot) assays - a very commonly applied immunological technique …
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Identification, Characterization, and Developmental Analyses of A Growth Cone Specific Epitope and a Synaptic Vesicle Protein
<p>This thesis describes a growth cone specific epitope (CD'A 1), a synaptic vesicle antigen (SVP38), and the developmental expression of each in various tissues. Although CD'A 1 and SVP38 do not have any direct relationship to each other, I will show that the expression of both changes over the …
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Anti-idiotype antibodies and phage displayed peptides as antigenic mimics of a Mycoplasma capricolum subsp. capripneumoniae epitope
… fragments directed against Mccp membrane protein epitopes was injected into hens to induce the production of anti-idiotype antibodies. The antibodies produced were functionally able to mimic the epitope recognised by the Mab since they inhibited binding of the Mab to mycoplasmal lysate. Mice were …
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Oligomers of beta-L-arabinosides of hydroxyproline : synthesis of the carbohydrate epitope of the Art v 1 allergen
… the search to establish the minimal carbohydrate epitope of Art v 1. The â-arabinoside motif, being a 1,2-cis glycoside, presents a considerable challenge to organic synthesis. Methods for the stereoselective introduction of furanosides are not as well developed as for their pyranoside …
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Epitope mapping of the E2 glycoprotein, including the hypervariable region 1, of the hepatitis C virus genotype 3a, in the context of humoral immune pressure
… conserved viral structures and vulnerable HCV epitopes. Twenty genotype 3a serum and plasma samples from patients with chronic HCV infections were obtained from the National Virus Registry Laboratory (NVRL) and from the Molecular Virology Research and Diagnostic Laboratory (MVDRL). HCV genotype …
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