Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 65 for “"epithelial-mesenchymal transition (EMT)"”.
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Investigating Novel Inhibitors of Epithelial - Mesenchymal Transition (EMT) and Cancer Stem Cells (CSCs) in Pancreatic Cancer
… of CSCs is highly associated with cancer cell epithelial-mesenchymal transition (EMT), which contributes to the plasticity of cancer cells and comprises an initial step for metastasis. Inhibiting EMT and CSCs in pancreatic cancer could potentially inhibit pancreatic cancer progression, …
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The Effects of Tracheal Occlusion on Wnt Signaling in a Rabbit Model of Congenital Diaphragmatic Hernia
… diaphragmatic hernia (CDH), but its effect on epithelial-mesenchymal transition (EMT) in lung development remains poorly understood. The purpose of this study was to a) confirm the CDH rabbit model produced PH which was reversed by TO and b) determine the effects of CDH +/- TO on EMT pathways. …
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Delineating metastasis in MSS colorectal cancer by single - cell RNA sequencing
… may promote tumor cell proliferation via the Epithelial-Mesenchymal Transition (EMT) pathway. Immune cell analysis highlighted significant differences in the proportion and functional status between primary and metastatic sites. Correlation analyses suggest that there may be crosstalk between …
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Breast Cancer Cells Acquire a Stem-Like Phenotype by TGFß1/EGF Induced Epithelial-Mesenchymal Transition
Epithelial-Mesenchymal Transition (EMT) is a key developmental program that is often activated during cancer invasion and metastasis. In breast cancer, EMT is associated with cancer stem cell properties including expression of the stem cell antigenic profile, over-expression of transcription …
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Alternative mechanisms of translation initiation in modulation of gap junctional coupling
… that can regulate gap junction formation. Using epithelial-mesenchymal transition (EMT) as a cellular model of gap junction remodeling, we have demonstrated altered translation initiation of Gja1 as a mechanism by which cellular Cx43 gap junctions can be dynamically regulated. Suppression of Gja1 …
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Trim24 Orchestrates Metabolic Reprogramming and Emt In Breast Cancer
… coupled with metabolic reprogramming and epithelial mesenchymal transition (EMT) in breast cancer. TRIM24 was first established by our laboratory as a previously unknown negative regulator of p53 via its RING domain, as a co-regulator of nuclear receptors and a PHD/Bromodomain reader of …
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PRUNE_1 INVOLMENT IN TNBC ENHANCING CANCER METABOLISM
… overexpression is associated with metastasis, epithelial-mesenchymal transition (EMT), and poor prognosis in cancers. It modulates intracellular pathways, including WNT and TGF-β signaling, through interactions with cytoskeleton proteins and kinases. Using a genetically engineered mouse model …
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The role of sphingosine kinases in pulmonary fibrosis
… major mechanisms of fibroblast accumulation is epithelial-mesenchymal transition (EMT) and the Transforming Growth Factor-β1 (TGF-β1) is one of the growth factors that regulate this transition. Sphingosine kinases (SK) are promising new targets for pulmonary fibrosis as they regulate the balance …
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Analysis of lipid metabolism regulators in breast cancer cells after induction of the Epithelial to Mesenchymal Transition
… of tumor metastasis is often enabled by the epithelial-mesenchymal transition (EMT), a key developmental program that is often activated during cancer invasion and metastasis. During the EMT process, cells undergo phenotypic changes, lose of E-cadherin expression and acquire invasive …
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Role of Type III TGF-β Receptor Shedding in Regulating Tumorigenesis
… TβRIII-SS in lung cancer cell models induces epithelial-mesenchymal transition (EMT) and that these TβRIII-SS (EMT) cells are less migratory, invasive and adhesive and more resistance to gemcitabine. Moreover, TβRIII-SS (EMT) cells exhibit decreased tumorigenicity but increased tumor growth in …
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Mechanisms of Intercellular Communication During Breast Cancer Progression Through Metastasis
… One mechanism that facilitates metastasis is epithelial-mesenchymal transition (EMT), which can be induced in cancer cells following the secretion of growth factors by tumor-associated macrophages (TAMs). During EMT, epithelial cells lose their cell-cell junctions, resulting in an alteration …
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The role of microvesicles in EMT and tumour microenvironment
… in this study was determined on normal prostate epithelial cell lines. PNT2 cells were treated with Jurkat cell derived-MVs lost epithelial characteristic (decreased epithelial marker E-cadherin) and gained mesenchymal phenotype (increased expression of mesenchymal marker Vimentin). TGF-β and …
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Inflammation triggers Zeb1-dependent escape from tumor dormancy
… leading to the activation of the cell-biological epithelial-mesenchymal transition (EMT) program in dormant disseminated cancer cells in vivo, and subsequent metastatic outgrowth. To model metastatic cellular dormancy, I used a dormant subpopulation of cells (D2A1-d) that were enriched for in vivo …
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ZEB1 is a central mediator of the Epithelial-Mesenchymal Transition
Carcinomas are solid tumors arising from epithelial tissue, and account for the majority of cancer deaths in the United States. In most occurrences of carcinoma, it is the metastases that kill, not the primary tumor. The Epithelial-Mesenchymal Transition (EMT) provides a model by which tightly …
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Metabolic reprogramming associated with the epithelial-mesenchymal transition in pancreatic cancer
… both of which partially underlined by the epithelial-mesenchymal transition (EMT). While the role of Warburg metabolism has been recognised in supporting rapid cellular growth and proliferation in many cancer types, less is known about the metabolic changes occurring during EMT, …
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Function and Regulation of the Cell Fate Determinant Numb in Polarized Epithelial Cells
… conserved in vertebrates. In mammalian polarized epithelial cells, Numb is distributed asymmetrically along the basolateral membrane domain. The work herein describes phosphorylation of Numb by the Par complex protein, atypical Protein Kinase C (aPKC), as a means of regulating membrane …
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Assessing the temporal role of miR-200 loss in murine models of NSCLC
… is the big killer in NSCLC and is driven by epithelial-mesenchymal transition (EMT) and immune evasion. The microRNA 200 family is a master regulator of EMT and is implicated in immune regulation. In this study we have developed a novel genetically engineered mouse model (GEMM) and derived …
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Understanding Human Astrovirus from Pathogenesis to Treatment
… disruption of the gut epithelium by induction of epithelial-mesenchymal transition (EMT) following astrovirus infection. Here we characterize HAstV-induced EMT as an upregulation of SNAI1 and VIM with a down regulation of CDH1 and OCLN, loss of cell-cell junctions most notably at 18 hours …
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Bone Morphogenetic Protein Signalling in Adult Lung Epithelial Cells
… a role for BMP signalling in adult airway epithelial cells (AECs) and to further investigate BMP signalling during airway inflammation. AECs used included the transformed bronchial cell line, BEAS-2B, the adenocarcinoma-derived cell line, A549, and normal primary murine airway epithelial …
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The role of prostate cancer microvesicles in epithelial mesenchymal transition
… metastasis. Most carcinomas are derived from epithelial cell lines, which normally adhere together tightly to form the structural foundations of many organs. Epithelial Mesenchymal Transition (EMT) has been linked to malignancy in many carcinomas of epithelial origin. In this study, I look at …
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