Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 109 for “"epithelial-mesenchymal transition"”.
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Gene regulatory networks controlling an epithelial-mesenchymal transition
Epithelial-mesenchymal transitions (EMTs) are fundamental and indispensable to embryonic morphogenesis throughout the animal kingdom. At the onset of gastrulation in the sea urchin embryo, micromere-derived primary mesenchyme cells (PMCs) undergo an EMT process to ingress into the blastocoel, and …
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The epithelial-mesenchymal transition of hepatocyte in liver cirrhosis
… cirrhosis is yet undetermined. We surmised that epithelial-mesenchymal transition (EMT) of hepatocytes might contribute to both hepatocyte dysfunction and liver fibrogenesis. To address this issue, hepatocytes were isolated from normal rat liver and from dimethylnitrosamine (DMN)-induced fibrotic …
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The role of prostate cancer microvesicles in epithelial mesenchymal transition
… metastasis. Most carcinomas are derived from epithelial cell lines, which normally adhere together tightly to form the structural foundations of many organs. Epithelial Mesenchymal Transition (EMT) has been linked to malignancy in many carcinomas of epithelial origin. In this study, I look at …
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ZEB1 is a central mediator of the Epithelial-Mesenchymal Transition
Carcinomas are solid tumors arising from epithelial tissue, and account for the majority of cancer deaths in the United States. In most occurrences of carcinoma, it is the metastases that kill, not the primary tumor. The Epithelial-Mesenchymal Transition (EMT) provides a model by which tightly …
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Pumilio Regulates the Epithelial-Mesenchymal Transition and Gastrulation During Zebrafish Development
… gene signaling and cell motility, as gained by epithelial-to-mesenchymal transitions (EMT), to occur. In pum1 morphants, both the presentation of wild-type signaling gradients and EMT events are inhibited. Through in silico and in vivo analysis, acvr1b, an Activin receptor, was identified as a …
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PTEN loss induces epithelial-mesenchymal transition in human colon cancer cells
Background: Epithelial-mesenchymal transition is a critical early event in the invasion and metastasis of many cancers, including colorectal cancer. Chronic inflammation is an inducer of several cancers and inflammatory cytokines have been implicated in tumor invasion. Materials and Methods: Human …
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Metabolic reprogramming associated with the epithelial-mesenchymal transition in pancreatic cancer
… both of which partially underlined by the epithelial-mesenchymal transition (EMT). While the role of Warburg metabolism has been recognised in supporting rapid cellular growth and proliferation in many cancer types, less is known about the metabolic changes occurring during EMT, …
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Regulation of Foxc2 Expression and Function During Epithelial-Mesenchymal Transition By Gsk-3Β
… treatment with TWS119 eventually induces epithelial morphology and decreased stem cell properties including sphere formation in these cells. Further characterization of FOXC2- GSK-3β interaction and the associated signaling cascade are necessary to determine the effect of FOXC2 …
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Investigating the relationship between miRNA expression and epithelial mesenchymal transition in colorectal cancer
Introduction: Epithelial-mesenchymal transition (EMT) is characterized by the loss of an epithelial phenotype and gain of a mesenchymal phenotype, i.e., migratory and metastatic properties. The EMT process is therefore characterized by a low expression of E-cadherin and high expression of …
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Investigating the role of the Hippo pathway in epithelial-mesenchymal transition and drug resistance
… a strong correlation with this kinase in mesenchymal-like cells. Inhibition of ZAK reversed the mesenchymal phenotype, and overexpression of ZAK resulted in epithelial-mesenchymal transition (EMT). Analysis of The Cancer Genome Atlas (TCGA) data shows a strong correlation between ZAK …
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Breast Cancer Cells Acquire a Stem-Like Phenotype by TGFß1/EGF Induced Epithelial-Mesenchymal Transition
Epithelial-Mesenchymal Transition (EMT) is a key developmental program that is often activated during cancer invasion and metastasis. In breast cancer, EMT is associated with cancer stem cell properties including expression of the stem cell antigenic profile, over-expression of transcription …
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Investigating Novel Inhibitors of Epithelial - Mesenchymal Transition (EMT) and Cancer Stem Cells (CSCs) in Pancreatic Cancer
… of CSCs is highly associated with cancer cell epithelial-mesenchymal transition (EMT), which contributes to the plasticity of cancer cells and comprises an initial step for metastasis. Inhibiting EMT and CSCs in pancreatic cancer could potentially inhibit pancreatic cancer progression, …
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Prognostic and Treatment Predictive Markers Associated with Cyclin D1 Gene Amplification and Epithelial-Mesenchymal Transition in Breast Cancer
… a potential adverse effect of tamoxifen, or with epithelial-mesenchymal transition (Snail), a biological process crucial for the development of metastasis. Immunohistochemical analyses of the biomarkers were predominantly performed in a breast cancer cohort including premenopausal patients …
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Analysis of Immunomodulatory Effects of Vitamin D in Epithelial-Mesenchymal Transition and Airway Remodeling in Allergic Airway Inflammation.
… in the host is the epithelium. In the lung, the epithelial layer provides not only a passive physical barrier, but also acts as an active protector through the release of antimicrobial agents, cytokines, and other factors which can activate the innate and adaptive immune system. Patients that …
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The P63 Isoform ∆Np63Α Inhibits Epithelial – Mesenchymal Transition By Promoting The Expression of Mir-205 In Human Bladder Cancer Cells
… of the ∆Np63α isoform in bladder cancer (BC). Epithelial – mesenchymal transition (EMT) is a physiological process that plays an important part in metastasis and drug resistance. At the molecular level, EMT is characterized by the loss of the epithelial marker E-cadherin, and the acquisition of …
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Gsk3B Regulates Epithelial-Mesenchymal Transition and Cancer Stem Cell Properties and Is A Novel Drug Target For Triple-Negative Breast Cancer
… <p><strong>GSK3β regulates Epithelial-Mesenchymal-Transition and Cancer Stem Cell properties and is a novel drug target for Triple-Negative Breast Cancer.</strong></p> <p>Geraldine Vidhya Raja, MS.</p> <p>Advisory Professor: Sendurai Mani, Ph.D.</p> <p>Triple-Negative breast …
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The Role of FGFR4 in Trigeminal Placode Cell Development
… in the trigeminal placode as cells undergo an epithelial-mesenchymal transition and begin to migrate toward the condensing ganglion. Because of the restricted spatiotemporal expression of FGFR4 in the opV placode, it was hypothesized that FGFR4 is necessary for the process of …
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Tracing clonal cell plasticity in the microenvironment of pancreatic ductal adenocarcinoma
… metaplasia and dedifferentiation by epithelial-mesenchymal transition, which contributes in largely unknown ways to metastasis in pancreatic cancer. As with most solid tumours, pancreatic ductal adenocarcinoma develops at the interface of cellular plasticity, genomic instability, and …
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Assessing the temporal role of miR-200 loss in murine models of NSCLC
… is the big killer in NSCLC and is driven by epithelial-mesenchymal transition (EMT) and immune evasion. The microRNA 200 family is a master regulator of EMT and is implicated in immune regulation. In this study we have developed a novel genetically engineered mouse model (GEMM) and derived …
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