Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 54 for “"epithelial tissues"”.
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The localisation and role of Sidekick at apical vertices in Drosophila epithelial morphogenesis
During animal development, epithelial tissues undergo morphogenesis in order to build tissues, organs and body structure. A key driving force in epithelial morphogenesis is cell rearrangement, which results from the remodelling of cell-cell contacts. In epithelia, cell-cell contacts are connected …
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Active Vertex Model of Epithelial Monolayer Mechanics
… studies of the mechanics of confluent epithelial tissues consisting of tens of thousands of cells, with a level of detail inaccessible to similar methods is presented. The AVM combines the Vertex Model for confluent epithelial tissues with active matter dynamics. Cell contacts are …
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The spatial organization of the microtubule cytoskeleton and cell divisions promotes tissue morphogenesis
During embryonic development, epithelial tissues grow and become sculpted into complex shapes through highly coordinated cell behaviors, such as cell shape change and cell division. Both processes involve contractile forces generated from distinctly organized actomyosin networks. How cells …
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Development of a novel in vitro system for nasal drug delivery development
… to maintain the viability of a number of epithelial tissues, including porcine and rabbit nasal tissue, and rat ileal and Payers' patch tissue. The complete chamber including the upper nasal chamber has been shown to provide tissue viability for porcine and rabbit nasal tissue above that …
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The role of space in homeostasis and preneoplasia in stratified squamous epithelia
… was to investigate the dynamics in squamous epithelial tissues both in homeostasis and preneoplasia, using cellular automata (CA) models. Stem cell dynamics has been shown to be accurately described by a simple mathematical model, the single progenitor (SP) model. Reliable parameterisation of …
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Genetic regulation of cell extrusion in caenorhabditis elegans
… primary method of cell elimination in mammalian epithelial tissues, such as the small intestinal epithelium. A specific set of cells is eliminated by cell extrusion by caspase-deficient C. elegans embryos.
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Sexing Study of Interphase Duodenum and Liver Nuclei in the Sixteen-Day Chick Embryo
… staining procedure was performed on sectioned epithelial tissues of the intestinal villi as well as sections and squashes of liver tissues. All chromatin masses, not just those suspected to represent sex chromatin, were recorded using a blind technique. The size, location and stain intensity of …
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Absorption of carnosine and methionylglycine by sheep ruminal and omasal epithelia
… Carnosine was transferred intact across both tissues. More carnosine was absorbed (P < .02) and transferred (P < .01) by the omasal epithelia. Methionylglycine was transferred intact across both tissues, but less (P < .01) remained intact in serosal buffer after 240 min incubation with omasal …
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The Role of Merlin and Apicobasal Polarity In Endometrial Development and Homeostasis
… for the proper formation and organization of epithelial tissues. Merlin couples cell polarity and adhesion through correct localization of the polarity protein Par3 and maturation of apical junctions. Merlin and Par3 are necessary for the development and homeostasis of highly regenerative …
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Gene Expression in the Choanoderm
… they are composed of few cell types and simple tissues that function to pump water through an internal canal network where bacterial prey are filtered by a specialized tissue called the choanoderm. The choanoderm is composed of cells with striking similarity to choanoflagellates, the unicellular …
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Characterization of the Ets-family transcription factor Ets98B in Drosophila
… in humans, is expressed in a subset of normal epithelial tissues in adults. Its expression appears to be altered in many prostate and breast cancers, but its basic biology and normal role in development remain uncharacterized. Ets98B appears to be the Drosophila homolog of PDEF. Ets98B is …
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Morphogenetic forces planar polarize LGN/Pins in the embryonic head during Drosophila gastrulation
During embryonic development, epithelial tissues grow and undergo dramatic changes to adopt complex shapes. Coordinated cell behaviors, including oriented cell divisions are crucial to the proper development of epithelia. How forces are transmitted across the developing embryo and how these forces …
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Rab35 Centered Membrane Trafficking Pathway Directs Apical Constriction During Drosophila Gastrulation
<p>Force generation in epithelial tissues is often pulsatile, with actomyosin networks generating high-tension contractile forces at the cell cortex before cyclically disassembling. This pulsed nature of cytoskeletal forces implies that there must be cellular processes to extract unidirectional …
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INVESTIGATING ALTERNATIVE SPLICING REPROGRAMMING REGULATED BY THE E-CADHERIN/B-CATENIN AXIS
… in myosin VI, an actin motor protein. In healthy epithelial tissues like the ovary and intestine, this exon cassette is carefully regulated, producing the myosin VIlong isoform involved in endocytic functions. However, in epithelial tumors like colorectal adenocarcinoma (COAD), aberrant splicing …
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Role of the Ajuba LIM Proteins in Epithelial Growth Regulation
… cytosolic adapter proteins recruited to nascent epithelial adherens junctions, where they are thought to contribute to junctional assembly and/or stability. They also shuttle into the nucleus acting as corepressors of the Snail family of transcriptional repressors, thereby contributing to …
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Biochemical and Immunocytochemical Characterization of Canine Corneal Cells Cultured in Two Different Media
… superior growth when cultured in a fully defined epithelial selective medium, Epilife®, compared to Dulbecco's modification of Eagle's medium (DMEM) with fetal bovine serum (FBS), and to characterize cultured canine corneal cells. Superficial keratectomies were performed on three dogs. Samples …
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Computational Modeling of Claudin-15 Paracellular Channels
… (TJs) regulate paracellular permeability in epithelial tissues through claudin protein assemblies, yet the molecular basis of strand flexibility, pore architecture, and ion selectivity for cation-selective claudin-15 (Cldn-15) remains incompletely defined at atomic resolution. This …
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Morphological Features of Dysplastic Progression in Epithelium: Quantification of Cytological, Microendoscopic, and Second Harmonic Generation Images
… quantification on several imaging systems and epithelial tissues. Quantification carries the benefit of creating numerical baselines and thresholds of healthy and abnormal tissues, to potentially aid clinicians in determining a diagnosis, as well as providing researchers with standardized, …
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MODELLING CELL POPULATION GROWTH
… compute and study the mechanical properties of tissues during growth and confluency, a theoretical and computational framework, called CellSim3D, was developed in our group based on a three-dimensional kinetic division model. In this work, CellSim3D is updated with a new set of cell mechanical …
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big bang, a novel regulator of tissue growth in Drosophila melanogaster
… the mechanisms that regulate tissue growth in epithelial tissues, in order to generate organs of correct size and proportion, remains a crucial goal of developmental biology. A suitable epithelial tissue for studying tissue growth in Drosophila, is the proliferative monolayer epithelial sheet …
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