Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 16 of 16 for “"epithelial surfaces"”.
-
Microbial interactions with epithelial surfaces.
Background. Staphylococcus aureus is an important gram positive pathogen that causes a multitude of human diseases. Many of these diseases are associated with the production of staphylococcal exotoxins. Superantigens are a family of staphylococcal exotoxins associated with many of these illnesses. …
-
Antibacterial peptides - key players in host defense at epithelial surfaces
Innate host defense mechanisms at epithelial surfaces are important to prevent bacterial invasion. Streptococcus pyogenes, group A streptococcus (GAS), has an affinity for epithelial cells and cause pharyngitis. During streptococcal pharyngitis, high concentrations of the chemokines CXCL9/MIG, …
-
Interactions of human immunodeficiency virus type 1 with mucosal epithelial surfaces and Candida albicans
… mode of HIV-1 transmission is through mucosal surfaces, the oral epithelium appears to be less susceptible to HIV-1 infection than vaginal epithelium. In addition, infections with co-pathogens that elicit immune activation, such as Candida albicans, may also promote HIV-1 infection. The project …
-
Epigenetic Memory of Mouse Intestinal Inflammation
The gut, encompassing one of the largest epithelial surfaces in the body, interacts with both biological and non-biological agents that can cause regular injury. Fortunately, the small intestinal epithelium has a remarkable capacity to repair itself after severe injury, due to the abundance of …
-
The Ligand and Function of the RegIII Family of Bactericidal C-Type Lectins
… in preventing bacterial incursions across gut epithelial surfaces. Mucosal epithelial cells produce a variety of secreted antimicrobial proteins that help to prevent bacterial attachment and encroachment at epithelial surfaces. Among these, Paneth cells are specialized small intestinal …
-
Dynamic Behaviors of Langerhans Cells In Situ
The epithelial surfaces of the body, being constantly exposed to both innocuous and potentially harmful substances and organisms, are protected by an array of immune cells called Langerhans cells (LCs). As a bridge between the innate (non-specific) and adaptive (specific) immune responses, LCs …
-
Epithelial Cell Autophagy in Antibacterial Defense of the Small Intestine
… disease (IBD), and bacteremia. As a result, epithelial cell innate immune responses play an essential role in preventing bacterial invasion of host tissues and maintaining a symbiotic host-bacterial relationship. Autophagy is emerging as an important component of innate immunity. Mounting …
-
A study of the functional anatomy of the bovine cervix with special reference to the epithelium, mucus secretion and sperm transport
… both computer-aided and plexiglas assembly of epithelial tracings, 3. Histochemical investigation using five follicular phase animals (four bred naturally 8 to 12-h before slaughter) and three luteal phase animals. Cross-sections of two samples from each quarter cervix were stained with (1) …
-
The regulation of bacterial virulence by mucin glycans
… for beneficial organisms, and protect host epithelial surfaces. These properties motivate the creation of mucin-inspired materials that can reproduce the protective effects of mucin in patients with mucosal disorders or infections. This thesis reports the production of bioactive …
-
MUCIN-MEDIATED AND INTERFERON-DRIVEN DEFENSE MECHANISMS AGAINST INFLUENZA VIRUS INFECTION IN HUMAN AIRWAY EPITHELIUM
… proteins termed mucins. Additionally, underlying epithelial cells produce interferons upon virus detection that promote the establishment of a local antiviral state through autocrine and paracrine signaling. However, despite these protective measures, IAV continues to cause significant annual …
-
Developing methods of selective, location-specific drug delivery in the gastrointestinal tract
… that compose the mucus layers, which cover the epithelial surfaces of the GI tract. These mucins are expressed differently in different regions of the GI tract. As such, the work in this thesis primarily aims to identify potential ligands (small molecule and peptide) that can selectively bind to …
-
Biospectroscopy towards screening and diagnosis of cancer
… were able to segregate different types of epithelial ovarian carcinomas. The accurate diagnosis obtained using ATR-FTIR spectroscopy demonstrates its potential for development as an assisting tool for histopathological diagnosis. The endometrial-myometrial junction areas of benign uterine …
-
Generation and circuit development of zebrafish retinal horizontal cells
… horizontal precursor cell is unattached to the epithelial surfaces, and instead migrates freely and divides near the final laminar location of mature HCs. I then determined what cellular changes take place in order for postmitotic HCs to establish their specific connectivity with rod and cone …
-
Midkine - a host defence protein
… harmful microbes in our environment. The epithelial linings constitute an anatomical barrier protecting us and they also produce antimicrobial polypeptides (AMPs) that act as a chemical barrier. These AMPs are small and positively charged, killing a broad range of microbes rapidly. They …
-
IMMUNOMODULATION AND INTESTINAL BARRIER PROTECTION ACTIVITIES OF A NOVEL SYNTHETIC GLUCOSE ANALOGUE IN INFLAMMATORY ANIMAL MODEL OF COLITIS AND ASTHMA.
The mucosal surfaces of the gastrointestinal and respiratory tracts are the main interfaces between the environment and the host. All two are protected by continuous epithelia that prevents the entry of microbes and integrity loss of these epithelia commonly predispose to infection. On the other …
-
Composición de la microbiota en pacientes pediátricos con déficit de hormona de crecimiento antes y después de recibir tratamiento con hormona de crecimiento
… Generally, commensal microorganisms populate all epithelial surfaces of the body, the most numerous and complex being the gut. Alterations in the composition and functionality of the microbiota (dysbiosis) have been associated with various pathologies. Among the different functions of the …