Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"epithelial stem cells"”.
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Growth Factors Up-Regulate Epithelial Stem Cells: Treatment Strategies for Colorectal Cancers
… effects of progastrin on target cells. The studies in chapter 2, conclude that ANXA2 mediates growth effects of PG on target cells (including colonic-epithelial-cells), in vitro and in vivo, associated with up-regulation of stem/progenitor cell markers. Surprisingly, …
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A Signal to Divide: Apoptotic Extracellular Vesicles as Carriers of Mitogenic and Immunogenic Signals
<p>Efficient replacement of dead cells in epithelial tissue is crucial for maintaining barrier function and tissue homeostasis. Apoptotic cells can signal to neighboring cells to stimulate proliferation and compensate for cell loss and maintain overall cell numbers in normal physiology and cancer. …
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Effects of Milk Replacer Composition on Measures of Mammary Development in Holstein Heifer Calves
… axis gene expression, and putative mammary epithelial stem cells. The hypothesis was that diet during the pre-weaning period alters the development, persistence, or activity of populations of putative mammary epithelial stem cells, possibly through involvement of GH/IGF-I axis molecules. …
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The Skin Remembers: Epigenetic Memories of Inflammation Past
… the foremost torchbearers of this task are skin epithelial stem cells (EpSCs). EpSCs reside in the basal layer of the skin, survive long-term, and are capable of both self-renewing and differentiating into multiple skin lineages. To efficaciously maintain the barrier, EpSCs must be able to sense …
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Investigation of regulatory functions of micrornas in skin and hair follicle development and cycling. A role of microRNA-214 in skin and hair follicle homeostasis.
… postnatal skin, and is highly expressed in the epithelial stem cells and their lineage-committed progenies. The effects of miR-214 on HF morphogenesis and cycle progression were evaluated by using doxycyclineinducible miR-214 transgenic mice (K14-rtTA/TRE-miR-214). Keratinocyte specific miR-214 …
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The role of CD133 in mouse incisor tooth epithelium
… isolate and characterise many different stem cell types across a wide variety of tissues. Nonetheless, to date not much has been elucidated about its function in these cells. The continuously growing mouse incisor contains a large population of epithelial stem cells that drive the …
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Specification And Function Of Early Hair Follicle Stem Cells
<p>In adult skin, multipotent epithelial stem cells (SCs) reside in a quiescent niche associated with each hair follicle termed the "bulge" and are essential for cyclic bouts of hair growth. Bulge stem cells can also contribute to sebaceous glands and the intefollicular epidermis when it is …
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The Role of Hyaluronan in the Ocular Surface
… in ocular tissues, particularly in the limbal stem cell niche and the meibomian gland. Methods: (1) To determine the role of HA in the limbal stem cell niche, primary human limbal epithelial stem/progenitor cells were isolated and expanded onto differently coated cultures with or without HA and …
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Primary culture of human limbal-corneal epithelial cells under different conditions
The corneal epithelium is renewed by limbal stem cells (LSCs). Absence, damage or loss of the LSC population leads to the painful and blinding condition of LSC deficiency (LSCD). In vitro expansion of LSCs is an increasingly well recognized treatment modality for LSCD. The purpose of this study was …
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Repair and restitution in the gastrointestinal tract after exposure to a cancer chemotherapy drug.
Chemotherapy and radiotherapy target neoplastic cells. However, they also adversely affect progenitor cells throughout the healthy alimentary tract, resulting in severe ulceration and pain. This affects around 500,000 patients annually. The aims of the present research were to identify the main …
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Understanding cornea stem cells during homeostasis and wound healing in Xenopus
… and wound healing are supported by specialized stem cells, that include the cornea epithelial stem cells (CESCs). Damage to or loss of these cells results in blindness and other debilitating ocular conditions. Here, we focus on cornea epithelial stem cell deficiency (commonly called limbal stem …