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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"epithelial sodium channel"”.
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Regulatory mechanisms of epithelial sodium channel
Epithelial sodium channels (ENaC) are of immense importance, controlling Na+ transport across epithelia and thus playing a critical role in all aspects of fluid clearance as well as numerous other functions. Although extensive studies have been carried out to invistegate the regulation mechanism of …
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Identification of Residues Critical to Epithelial Sodium Channel Assembly
The Epithelial Sodium Channel (ENaC) is a major determinant in fine-tuning the volume and pressure of blood within the cardiovascular system. Understanding the regulation, structural assembly, and arrangement of ENaC is needed. This study describes a method for identifying residues that participate …
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Hormone-induced expression of the epithelial sodium channel in human airway cells
… of these dangerous conditions is due to active sodium reabsorption through the epithelial sodium channel (ENaC), which is crucial for lung fluid clearance. Although clinical prognosis can be improved by using glucocorticoid hormones to augment the ENaC-dependent removal of liquid from the lungs, …
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Renal Epithelial Sodium Channel (ENaC) Regulation of Pregnancy Mediated Hemodynamic Adaptations: Mechanistic Insights
<p>Pregnancy-mediated sodium (Na) retention is required to provide an increase in plasma volume for the growing fetus. The mechanisms responsible for this Na retention are not clear. In the first study, we generated a renal tubule protein profile indicating α ENaC as the only sodium transport …
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Uncovering the Critical Amino Acids in the Beta Bubunit of the Epithelial Sodium Channel (ENaC)
A high intake of sodium into the body can lead to high blood pressure that could result to stroke, kidney and heart disease. Sodium balance in the body is partially regulated in the distal tubules of the nephron in the kidney via a membrane channel called the epithelial sodium channel (ENaC). The …
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The R563Q mutation of the beta subunit of the epithelial sodium channel : prevalence and effect
… contribute to blood pressure is ongoing. The epithelial sodium channel genes were implicated when the beta subunit (SCNN1B, gene ID 6338) was found to have a mutation that caused Liddle’s syndrome. The R563Q mutation in the beta subunit has been associated with hypertension and pre-eclampsia …
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The R563Q Mutation of the Beta Subunit of the Epithelial Sodium Channel: Prevalence and Effect
… contribute to blood pressure is ongoing. The epithelial sodium channel genes were implicated when the beta subunit (SCNN1B, gene ID 6338) was found to have a mutation that caused Liddle's syndrome. The R563Q mutation in the beta subunit has been associated with hypertension and pre-eclampsia …
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Identification of Accessory Proteins and Their Impact on the Expression of the Epithelial Sodium Channel (ENaC)
The epithelial sodium channel (ENaC) plays a crucial role in ensuring proper Na+ balance in the body. In the nephron, ENaC regulates the final 3-5% reabsorption of Na+ and is a limiting factor for Na+ reabsorption in the kidneys. Because of its role in the kidneys, ENaC is thought to be a critical …
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The development of novel strategies to modulate epithelial sodium channel (ENaC) activity in chronic obstructive pulmonary disease (COPD)
… RNA (siRNA) cargo into primary bronchial epithelial cells (PBECs). RALA/siRNA nanoparticles were well-tolerated by submerged PBECs and transfection of cells led to a high level of αENaC mRNA knockdown. Whilst local delivery to PBEC cultures at air-liquid interface (ALI) appeared promising, …
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Elucidation of the epithelial sodium channel as a salt taste receptor candidate and search for novel salt taste receptor candidates
… drug amiloride and specific for Na+, involving epithelial sodium channel (ENaC). A second rodent transduction pathway, which is triggered by various cations, is amiloride insensitive and not almost understood to date. Studies in primates showed amiloride-sensitive as well as …
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With No Lysine 1 (WNK1): A Potential Regulator of The Lysosomal Degradation Pathway
… and/or activity of various ion transporters and channels, including the epithelial sodium channel (ENaC) and the sodium chloride co-transporter (NCCT). Although the mechanisms for regulating these cell surface proteins are not well defined, it appears that WNKs may modulate the intracellular …
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Analysis of ASCL1 in Neuroendocrine Lung Cancer
… SCNN1A, which encodes the alpha subunit of the epithelial sodium channel (αENaC), is highly correlated with ASCL1 expression in SCLC cells. We confirmed that SCNN1A is under the transcriptional control of ASCL1, indicating that SCNN1A represents a newly recognized ASCL1 target. The product of …
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Analysis of the role of the mineralocorticoid receptor in renal principal cell sodium reabsorption in vivo
… early postnatal lethality due to massive loss of sodium and water associated with impaired epithelial sodium channel (ENaC) activity in kidney and colon. The aim of the present study was the analysis of the role of renal principal cell MR, which is activated by aldosterone, in ENaC-mediated sodium …
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Neuronal and Molecular Basis of Nociception and Thermosensation in Drosophila melanogaster
… the nociceptors, I next investigated several ion channels that are critical molecular components for larval nociception. The Degenerin Epithelial Sodium Channel (DEG/ENaC) protein called pickpocket (ppk) is required specifically for larval mechanical nociception but not for thermal nociception. …
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WNK Family Kinases and the Regulation of Ion Flux
… regulated endocytosis of ion transporters and channels. The mechanism is reliant on an amino terminal fragment of WNK that does not include the kinase domain. How WNK1 exerts this effect, however, remains unclear. This dissertation will detail the examination of the amino terminal fragment of …
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Significance of Protein Interactions in Mediating AF9 Function
… to negatively regulate the expression of the epithelial sodium channel α (ENaCα) gene in murine renal collecting ducts by modulating the activity of the Dot1l. It has been shown that Af9-Dot1l promotes H3K79 methylation at specific sites in the ENaCα promoter, which then contributes to its …
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Neuroanatomical Maps and Taste Reactivity to Sweet, Umami, and Bitter Taste in the PBN of C57BL/6J Mice
… first binds to or activates taste receptors or channels located inside taste buds found in the oral cavity. This transduction event then produces a cascade of neuronal activation via sensory nerves that innervate the taste buds –branches of three cranial nerves (VII, IX, and X). These cranial …
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Der Mineralokortikoidrezeptor ist keine Voraussetzung für die Stimulation des epithelialen Na+-Transportes durch Glukokortikoide-Messungen an der Mineralokortikoidrezeptor Knock-out Maus
… Arbeit befaßt sich mit der Regulation des epithelialen Na+-Transportes durch Mineralokortikoide und Glukokortikoide am Modell der Mineralokortikoid-Rezeptor Knock-out (MR-KO) Maus. Glukokortikoide steigern in Mineralokortikoid-empfindlichen Geweben, die sowohl den Mineralokortikoid-Rezeptor …